红曲菌发酵黄精渣生产monacolin K的探索性研究  

Exploring studies on bioproduction of monacolin K by solid fermentation of Polygonatum sibiricum waste using Monascus purpureus

作　　者：陈小林 南海珍 徐志南[2] CHEN Xiaolin;NAN Haizhen;XU Zhinan(Hangzhou Derunquan Health Industry Development Co.,Ltd.,Hangzhou 311500,China;Institute of Bioengineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,310027,China)

机构地区：[1]杭州德润全健康产业发展有限公司,浙江杭州311500 [2]浙江大学化工与生物工程学院生物工程研究所,浙江杭州310027

出　　处：《药学研究》2019年第1期12-15,共4页Journal of Pharmaceutical Research

基　　金：杭州市农业与社会发展科研计划项目(No.20172015A08)

摘　　要：目的开展以紫色红曲菌固体发酵黄精渣生产重要降血脂肪成分monacolin K的探索研究。方法系统考察了红曲菌发酵过程中黄精渣加入量、辅料黄豆粉与米粉的配比、含水量、发酵时间等因素对monacolin K产量的影响。结果在紫色红曲菌(Monascus purpureus)发酵黄精渣生产monacolin K的过程中,当含水量为40%、黄精加入量为70%,米粉与黄豆粉加入量为1∶1,在25℃下发酵30 d,monacolin K的产量可以达到16.21 mg·g^(-1)。结论这一新固体发酵方式既能充分利用黄精深加工废弃物,又能高效产生降血脂生物活性组分,是中药材深加工的一个切实可行的开发方向。Objective To produce monacolin K-containing hypolipidemic products with solid fermentation of Monasus purpureus by using Polygonatum sibiricum waste residues.Methods During the fermentation process,the effects of the added amount of Polygonatum sibiricum waste,proportion of soybean powder and rice powder,water content and fermentation time were investigated with regard to monacolin K productivity systematically.Results The highest productivity of monacolin K reached(16.21 mg·g-1)was obtained at the following suitable conditions:40%water content,70%Polygonatum sibiricum added,and a proportion of rice powder and soy powder at 1∶1 after 30 days fermentation at 25℃.Conclusion The novel solid fermentation method can make full use of Polygonatum sibiricum deep processing waste and efficiently produce hypolipidemic bioactive components,which will have potential important applications in the future.

关 键 词：红曲菌 黄精 发酵 MONACOLINK 

分 类 号：TQ925[轻工技术与工程—发酵工程]