Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain?  

作　　者：Zhefan Stephen Chen Ho Yin Edwin Chan 

机构地区：[1]School of Life Sciences,Faculty of Science,The Chinese University of Hong Kong [2]Gerald Choa Neuroscience Centre,The Chinese University of Hong Kong

出　　处：《Neural Regeneration Research》2019年第7期1148-1151,共4页中国神经再生研究（英文版）

基　　金：supported by the General Research Fund(14100714)of the Hong Kong Research Grants Council(to HYEC);The Chinese University of Hong Kong Vice-Chancellor’s One-Off Discretionary Fund(VCF2014011)(to HYEC);The Chinese University of Hong Kong One-of Funding for Joint Lab/Research Collaboration(3132980)(to HYEC);The Chinese University of Hong Kong Faculty of Science Strategic Development Fund(FACULTY-P17173)(to HYEC);The Chinese University of Hong Kong Gerald Choa Neuroscience Centre(7105306)(to HYEC);donations from Chow Tai Fook Charity Foundation(6903898)(to HYEC);Hong Kong Spinocerebellar Ataxia Association(6903291)(to HYEC);supported by the Postdoctoral Fellowship in Clinical Neurosciences of The Chinese University of Hong Kong,China

摘　　要：Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous system.Besides,YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous system.Besides,YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.

关 键 词：Alzheimer’s disease amyotrophic lateral SCLEROSIS neurodegeneration PROTEIN aggregates recruitment PROTEIN degradation SUBCELLULAR localization TRANSCRIPTIONAL regulation YIN Yang 1 

分 类 号：R[医药卫生]