Leukemia Inhibitory Factor Decreases Neurogenesis and Angiogenesis in a Rat Model of Intracerebral Hemorrhage  

作　　者：Chuan-zhen LIU Hua-jun ZHOU Jian-hua ZHONG Tao TANG Han-jin CUI Jing-hua ZHOU Qiang ZHANG Zhi-gang MEI 

机构地区：[1]Institute of Neurology,China Three Gorges University,Yichang 443003,China [2]Department of Neurology,The First College of Clinical Medical Sciences,Three Gorges University,Yichang 443003,China [3]Key Lciboratory of Translational Medicine of Cardiovascular and Cerebrovascular Diseases,China Three Gorges University,Yichang 443003,China [4]Depcirtment of Intensive Care Unit,The First College of Clinical Medical Sciences,Three Gorges University,Yichang 443003,China [5]Institute of Integrative Medicine,Xiangyci Hospital,Central South University,Changsha 410008,China [6]Medical College of China Three Gorges University,Yichang 443002,China

出　　处：《Current Medical Science》2019年第2期298-304,共7页当代医学科学（英文）

基　　金：the National Natural Science Foundation of China(Nos.81202625,30400581,30873221 and 81173175);the Project for New Century Excellent Talents(No.NCET-11-0522);the Hunan Provincial Natural Science Foundation(Nos.07JJ5007 and 10JJ2023);the Key Laboratory of Translational Medicine of Cardiovascular and Cerebrovascular Diseases(China Three Gorges University,No.2016KXN06).

摘　　要：Neurogenesis and angiogenesis can improve the neurologic function after intracerebral hemorrhage(ICH).Leukemia inhibitory factor(LIF)plays an important role in neurogenesis and angiogenesis.In this study,a rat model of autologous blood-induced ICH was used to evaluate the effect of LIF on the neurogenesis and angiogenesis following ICH.After ICH,LIF-positive neurons and dilated vessels were detected in the peri-hematomal region.It was found that LIF levels increased significantly and peaked 14 days after ICH induction.Double immunofluorescence confirmed that LIF was expressed in neurons and endothelial cells.ICH also led to increases of doublecortin(DCX)-and von Willebrand factor(vWF)-positive cells as well as proliferation of cell nuclear antigen(PCNA)+/DCX+and PCNA+/vWF+nuclei.All these ICH-induced increases were significantly attenuated by exogenous LIF in fusion.These data suggested that LIF was a negative regulator of neurogenesis and angiogenesis after ICH.

关 键 词：INTRACEREBRAL hemorrhage NEUROGENESIS ANGIOGENESIS LEUKEMIA INHIBITORY factor 

分 类 号：R[医药卫生]