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作品数：352被引量：723H指数：10
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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion
《Neural Regeneration Research》2025年第10期2838-2854,共17页Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du 
supported by the National Natural Science Foundation of China,Nos.82374561(to JD),82174490(to JF);the Medical and Health Science and Technology Program of Zhejiang Province,No.2021RC098(to JD);the Research Project of Zhejiang Chinese Medical University,Nos.2022JKZKTS44(to JD),2022FSYYZZ07(to JF).
Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairme...
关键词：anterior cingulate cortex ANXIETY chronic pain circuit communication COMORBIDITY depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission 
Inhibitory mechanism of flavonoids on dietary advanced glycation end products formation in food models
《Food and Health》2025年第2期35-38,共4页Meng-Yao Jin He Li 
financially supported by the National Natural Science Foundation of China(Grant No.32472468 and No.32001817);the Fundamental Research Program of Shanxi Province(202303021221123).
Advanced glycation end products(AGEs)are complex compounds formed through interaction of carbonyl groups from saccharides with amino groups in amino acids,proteins,lipids and nucleic acids,mainly via Maillard reaction...
关键词：flavonoid compounds advanced glycation end-products inhibitory mechanism reactive carbonyl species 
SMAD specific E3 ubiquitin protein ligase 1 accelerates diabetic macular edema progression by WNT inhibitory factor 1
《World Journal of Diabetes》2025年第3期216-231,共16页Li-Fang Liang Jia-Qi Zhao Yi-Fei Wu Hui-Jie Chen Tian Huang Xiao-He Lu 
Supported by Natural Science Foundation of Guangdong Province,No.2022A1515012346.
BACKGROUND Diabetic macular edema(DME)is the most common cause of vision loss in people with diabetes.Tight junction disruption of the retinal pigment epithelium(RPE)cells has been reported to induce DME development.S...
关键词：Diabetic macular edema Retinal pigment epithelium cells Autophagy SMAD specific E3 ubiquitin protein ligase 1 WNT inhibitory factor 1 N6-methyladenosine modification Vascular endothelial growth factor signaling pathway 
In Silico Inhibitory Potential of Isolated Molecules of Scoparia dulcis L. (Scrophulariaceae) on SARS-CoV-2 Main Protease Mpro
《Pharmacology & Pharmacy》2025年第2期31-51,共21页Moussa Ouedraogo Windbedema Prisca Ouedraogo Hermann W. Yameogo Inna T. Traore Raïnatou Boly Noufou Ouedraogo Rasmané Semde Sylvin Ouedraogo 
Background: The Coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-2 coronavirus, remains a global threat despite lifting the health emergency. Scientists from all continents have been mobilized to d...
关键词：COVID-19 Molecular Docking Mpro Biomolecules Scoparia dulcis 
Polyoxygenated cembrane-type diterpenes from the Hainan soft coral Lobophytum crassum as a promising source of anticancer agents with ErbB3 and ROR1 inhibitory potential
《Acta Pharmacologica Sinica》2025年第1期196-207,共12页Shou-mao Shen Dan-dan Yu Lin-mao Ke Li-gong Yao Ming-Zhi Su Yue-wei Guo 
This research was financially supported by the National Natural Science Foundation of China(Nos.22167010 and 81991521);the National Key Research and Development Program of China(No.2022YFC2804100);the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(No.23KJB350011);the Shandong Laboratory Program(SYS202205);the Basic Research Project of Guizhou University(No.2023-51).
A detailed chemical investigation of the Hainan soft coral Lobophytum crassum led to the identification of a class of polyoxygenated cembrane-type macrocyclic diterpenes(1-28),including three new flexible cembranoids,...
关键词：Lobophytum crassum macrocyclic diterpenes cembranoids anticancer agent ROR1 ERBB3 
Comprehensive analyses of inhibition of the Chinese traditional food-packaging materials,Indocalamus latifolius leaves(Zongye)on Aspergillus flavus
《Food Quality and Safety》2024年第4期720-739,共20页Wenjing Peng Xiaoxu Ren Haiting Dai Bowen Tai Bolei Yang Gang Wang Xu Li Fuguo Xing 
supported by the Beijing Natural Science Foundation(Nos.6212028 and 6222053);the National Natural Science Foundation of China(No.32372457);the Agricultural Science and Technology Innovation Program of Institute of Food Science and Technology,CAAS(No.CAAS-ASTIP-G2022-IFST-01).
Objectives:The contamination of Aspergillus flavus and aflatoxins(AFs)is one of the most serious safety problems in food and feed.The discovery and application of plant-sourced antifungal agents are hot topics in myco...
关键词：Indocalamus latifolius Zongye essential oil Aspergillus flavus AFLATOXIN inhibitory mechanism 
Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia
《Food Science and Human Wellness》2024年第6期3083-3094,共12页Guillermo Santos-Sánchez Ana IsabelÁlvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro 
funded by Consejería de Salud, Junta de Andalucía (PC-0111-2016-0111);PEMP-0085-2020 (cofinanciado con fondos FEDER, convocatoria Resolución de 7 de julio de 2021 de la Secretaría General de Investigación, Desarrollo e Innovación en Salud, que convoca subvenciones para financiar la investigación, el desarrollo y la innovación en Biomedicina y Ciencias de la Salud en Andalucía, para 2021);the Programa PAIDI from the Junta de Andalucía (CTS160);supported by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/02339);supported by the VI Program of Inner Initiative for Research and Transfer of the University of Seville (VIPPIT2020-II.4);by a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University (DOC_00587/2020);funded by Andalusian Government Ministry of Health (PI-0136-2019);supported by the VI Program of Inner Initiative for Research and Transfer of University of Seville
Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease burden.Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs.The biochemical mechanism o...
关键词：Functional foods Cholesterol Cardiovascular diseases STATINS 3-Hydroxy-3-methylglutaryl-coenzyme A 
Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex被引量：1
《Neuroscience Bulletin》2024年第11期1635-1648,共14页Yuhan Shi Jingjing Yan Xiaohong Xu Zilong Qiu 
supported by grants from the National Natural Science Foundation of China(31625013,81941015,82021001);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060202);the Program of Shanghai Academic Research Leaders,and the Science and Technology Commission of Shanghai Municipality(#2018SHZDZX05);supported by the GuangCi Professorship Program of Ruijin Hospital,Shanghai Jiao Tong University School of Medicine.
The retrosplenial cortex has been implicated in processing sensory information and spatial learning,with abnormal neural activity reported in association with psychedelics and in mouse and non-human primate models of ...
关键词：Social behavior Retrosplenial cortex Hippocampal CA1 
Encapsulation of Clove Oil Nanoemlusion in Chitosan-Based Nano-Composite: In Vitro and in Vivo Antifungal Activity against Rhizoctonia solani and Sclerotium rolfsii
《Phyton-International Journal of Experimental Botany》2024年第11期2787-2811,共25页Ahmed Mahmoud Ismail Eman Said Elshewy Isra HAli Naglaa Abd Elbaki Sallam Muhanna Eman Yehia Khafagi 
This research was kindly funded by the Deanship of Scientific Research,Vice Presidency for Graduate Studies and Scientific Research,King Faisal University,Saudi Arabia,grant number(KFU241802).
Rhizoctonia solani Kühn and Sclerotium rolfsii Sacc.are the primary soil-borne plant diseases responsible for sig-nificant reductions in global crop yields.The primary goal of this study was to investigate the antifun...
关键词：Black scurf chitosan clove oil DAMPING-OFF INHIBITORY nanocomposite NANOEMULSION stem canker 
NO inhibitory constituents from Glycosmis craibii var.glabra
《Chinese Journal of Natural Medicines》2024年第11期1040-1046,共7页CHEN Hongwei DING Meng LIN Jun YUAN Shuo ZENG Kewu TU Pengfei JIANG Yong 
supported by National Natural Science Foundation of China(Nos.81973199,82173949,and 81773864);the Key Research and Development Project of Shandong Province(No.2021CXGC010507)。
Six novel compounds,comprising three quinolones(1a,1b,and 2)and three flavanones(3-5),along with seven known analogs(6-13),were isolated from the 95%EtOH extract of the stems and leaves of Glycosmis craibii var.glabra...
关键词：Glycosmis craibii var.glabra QUINOLONE FLAVANONE NO inhibition 
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