秀丽隐杆线虫模型在食品营养评价中的应用研究进展  

Food Nutritional Evaluation: Caenorhabditis elegans as a Model Organism

作　　者：杨番 夏程程 钟晓凌[1] 李琴 李茜 张智源 史文博 徐宁[1] 吴茜[1] 胡勇[1] 柳志杰[1] 汪超[1] 周梦舟[1] YANG Fan;XIA Chengcheng;ZHONG Xiaoling;LI Qin;LI Xi;ZHANG Zhiyuan;SHI Wenbo;XU Ning;WU Qian;HU Yong;LIU Zhijie;WANG Chao;ZHOU Mengzhou(Hubei Cooperative Innovation Center for Industrial Fermentation, Research Center of Food Fermentation Engineering andTechnology of Hubei, Hubei University of Technology, Wuhan 430068, China;Wuhan Environmental Testing Center,Wuhan 430015, China;Hubei Accurate Inspection Testing Co. Ltd., Wuhan 430077, China)

机构地区：[1]湖北工业大学工业发酵湖北省协同创新中心,湖北省食品发酵工程技术研究中心,湖北武汉430068 [2]武汉市环境检测中心,湖北武汉430015 [3]湖北省阿克瑞德检验检测有限公司,湖北武汉430077

出　　处：《食品科学》2019年第11期268-276,共9页Food Science

基　　金：国家自然科学基金青年科学基金项目(31601455);“十三五”国家重点研发计划重点专项(2016YFD0400701);湖北省粮食局科技创新项目(鄂财商发[2017]58号)

摘　　要：食品营养一直是食品领域研究的重点和热点,近些年消费者对功能性食品的消费量逐年增加,而对食品的功能性评价需要模式生物来完成。秀丽隐杆线虫作为模式生物,具有信号通路同人类相似的优点,且成本低、易于培养。本文综述了秀丽隐杆线虫与人类信号通路的同源性,对食品中活性因子的营养功能进行分类评价,并且对秀丽隐杆线虫在食品营养评价中的研究进展进行总结,为食品营养研究以及功能性食品的研发提供参考。Food nutrition is always a research focus and hotspot in the field of food science. The consumption of functional foods has increased year by year. Model organisms are essential in the evaluation of food functionalities. Caenorhabditis elegans, a small free-living soil nematode, has been extensively used as an experimental in vivo system for biological studies due to its small size, short generation time, and suitability for genetic analysis. In this article, we summarize and review the homology of signaling pathways between C. elegans and humans, the classification and evaluation of functional food factors, and recent progress in the application of C. elegans in food nutritional evaluation, with the aim of providing a basis for food nutrition research and the development of functional foods.

关 键 词：食品营养 秀丽隐杆线虫 信号通路 营养评价 

分 类 号：TS201.4[轻工技术与工程—食品科学]