Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement  

作　　者：Beatriz Gonzalez Pablo Vera 

机构地区：[1]Instituto de Biologia Molecular y Celular de Plantas,Universidad Politecnica de Valencia-C.S.I.C,Ciudad Politecnica de la Innovacion,Edificio 8E,Ingeniero Fausto Elio,s/n.46022 Valencia,Spain

出　　处：《Molecular Plant》2019年第9期1227-1242,共16页分子植物（英文版）

摘　　要：Plants rely on primary metabolism for flexible adaptation to environmental changes.Here,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant immunity.Disruption of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced susceptibHity.Comparative proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant immunity.Overexpression of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant immunity.Take together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关 键 词：folate PATHWAY plant IMMUNITY METHIONINE DNA METHYLATION 

分 类 号：R73[医药卫生—肿瘤]