The neuroprotective role of Wnt signaling in the retina  

作　　者：Stefan Kassumeh Gregor R.Weber Matthias Nobl Siegfried G.Priglinger Andreas Ohlmann 

机构地区：[1]Department of Ophthalmology,University Hospital,LMU Munich,Mathildenstrasse 8,80336 Munich,Germany

出　　处：《Neural Regeneration Research》2021年第8期1524-1528,共5页中国神经再生研究（英文版）

基　　金：supported by the Deutsche Forschungsgemeinschaft(OH 214/4-3,FOR 1075,TP7)。

摘　　要：The canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and maturation of the central nervous system including the retina. It has a significant impact on retinal vessel formation and maturation, as well as on the establishment of synaptic structures and neuronal function in the central nervous system. Mutations in components of the Wnt/β-catenin signaling cascade may lead to severe retinal diseases, while dysregulation of Wnt signaling can contribute to disease progression. Apart from the angiogenic role of Wnt/β-catenin signaling, research in the last decades leads to the theory of a protective effect of Wnt/β-catenin signaling on damaged neurons. In this review, we focus on the neuroprotective properties of the Wnt/β-catenin pathway as well as its downstream signaling in the retina.

关 键 词：apoptosis β-catenin leukemia inhibitory factor Müller cells NEURODEGENERATION NEUROPROTECTION Norrin PHOTORECEPTORS RETINA retinal ganglion cells WNT 

分 类 号：R774.1[医药卫生—眼科]