α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome  

作　　者：Rui Wang Hongyang Sun Haigang Ren Guanghui Wang 

机构地区：[1]Laboratory of Molecular Neuropathology,Jiangsu Key Laboratory of Neuropsychiatric Diseases&Department of Pharmacology,College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China

出　　处：《Science China(Life Sciences)》2020年第12期1850-1859,共10页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(31871023,31970966);the National Key Scientific Research and Development Program of China(2016YFC1306000);Suzhou Clinical Research Center of Neurological Disease(Szzx201503);the Priority Academic Program Development of Jiangsu Higher Education Institutions。

摘　　要：The presence of intraneuronal Lewy bodies(LBs) and Lewy neurites(LNs) in the substantia nigra(SN) composed of aggregatedα-synuclein(α-syn) has been recognized as a hallmark of pathological changes in Parkinson’s disease(PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity. The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology.

关 键 词：Α-SYNUCLEIN Lewy pathology MITOCHONDRIA LYSOSOME AGGREGATION transmission 

分 类 号：R742.5[医药卫生—神经病学与精神病学]