Effect of Th1/Th2 balance on serum prostaglandin,COX-2,AVP and OT in primary dysmenorrhea rats with cold coagulation and blood stasis syndrome  

作　　者：Feng-Ting Zhai Dong-Mei Wang Qing Ma Wei-Ping Cao Dan-Dan Wang Guang-Wen Li 

机构地区：[1]Affiliated Hospital of Shandong University of TCM,Jinan 250014,China [2]Shandong University of Traditional Chinese Medicine(TCM),Jinan 250355,China

出　　处：《Journal of Hainan Medical University》2021年第15期1-5,共5页海南医学院学报（英文版）

基　　金：Shandong natural science foundation(No.ZR2019MH083);National Famous and Old Chinese Medicine Expert Li Guangwen Inheritance Studio;Wang Dongmei Shandong Province Famous and Old Chinese Medicine Expert Inheritance Studio。

摘　　要：Objective:Explore the role of Th1/Th2 balance in the pathogenesis of primary dysmenorrhea through study the effect of Th1/Th2 balance drift on serum prostaglandin F_(2α),prostaglandin,6-keto-prostaglandin F_(1α),TXB2,COX-2,AVP and OT in Primary Dysmenorrhea Rats with cold coagulation and blood stasis syndrome.Method:The rat model of primary dysmenorrhea with cold coagulation and blood stasis syndrome was established.On the basis of this model,Th1 shift model and Th2 shift model were established.The rats were divided into blank group,model group,Th1 shifting group and Th2 shifting group.The writhing reaction of rats in each group was compared,and the contents of PGF_(2α),PGE_(2),6-keto-PGF_(1α),TXB2,COX-2,AVP and OT in serum were detected.Results:Writhing latency:There was no significant difference between Th1 and Th2 shifting groups(P>0.05),Th2 shifting group was shorter than Th1 shifting group(P<0.05).Writhing times in 30 minutes:Compared with the model group,the writhing times of Th1 shifting group decreased significantly(P<0.01),while Th2 shifting group increased significantly(P<0.01).Compared with the blank group,the contents of PGF_(2α),TXB2,COX-2,AVP and OT were increased(P<0.05,P<0.01),and the contents of 6-keto-PGF_(1α)and PGE_(2)were decreased(P<0.01).Compared with the model group,the contents of PGF_(2α),TXB2,COX-2 and AVP in Th1 shifting group were decreased(P<0.05,P<0.01),and the contents of 6-keto-PGF_(1α)and PGE_(2)were increased(P<0.01),while the contents of PGF_(2α),TXB2,COX-2,AVP and OT in Th2 shifting group were increased(P<0.01),and the contents of 6-keto-PGF_(1α)and PGE_(2)were decreased(P<0.01).Conclusion:The intervention of Th1/Th2 cell balance on the expression of PGF_(2α),PGE_(2),6-keto-PGF_(1α),TXB2,COX-2,AVP and OT may be one of the pathogenesis of PD with cold coagulation and blood stasis syndrome.

关 键 词：Primary dysmenorrhea Th1/Th2 balance PROSTAGLANDIN CYCLOOXYGENASE-2 VASOPRESSIN OXYTOCIN 

分 类 号：R73[医药卫生—肿瘤]