The role of ALDH2 in tumorigenesis and tumor progression:Targeting ALDH2 as a potential cancer treatment  

作　　者：Hong Zhang Liwu Fu 

机构地区：[1]State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangdong Esophageal Cancer Institute,Sun Yat-sen University Cancer Center,Guangzhou510060,China

出　　处：《Acta Pharmaceutica Sinica B》2021年第6期1400-1411,共12页药学学报（英文版）

基　　金：funded by grants from the National Natural Science Foundation of China (81673463);the National Key Research and Development Program (No. 2018ZX09711002-003-011, China);the Guangdong Provincial Special Fund for Marine Economic Development Project (GDNRC [2020]042, China);Leading Talent Project of Guangzhou Development Zone (CY2018-002, China)。

摘　　要：A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2(ALDH2).The correlation between ALDH2 dysfunction and tumorigenesis/growth/metastasis has been widely reported.Either low or high ALDH2 expression contributes to tumor progression and varies among different tumor types.Furthermore,the ALDH2*2 polymorphism(rs671) is the most common single nucleotide polymorphism(SNP) in Asia.Epidemiological studies associate ALDH2*2 with tumorigenesis and progression.This study summarizes the essential functions and potential ALDH2 mechanisms in the occurrence,progression,and treatment of tumors in various types of cancer.Our study indicates that ALDH2 is a potential therapeutic target for cancer therapy.

关 键 词：ALDH2 POLYMORPHISM Cancer TUMORIGENESIS PROGRESSION Cancer therapy ACETALDEHYDE METASTASIS 

分 类 号：R730.2[医药卫生—肿瘤]