Progress in tumor vascular normalization for anticancer therapy:challenges and perspectives  

作　　者：Bingxue Shang Zhifei Cao Quansheng Zhou 

机构地区：[1]Cyrus Tang Hematology Center,Jiangsu Institute of Hematology,the First Affiliated Hospital of Soochow University,Suzhou 215123,China [2]Key Laboratory of Thrombosis and Hemostasis,Ministry of Health,Soochow University,Suzhou 215123,China

出　　处：《Frontiers of Medicine》2012年第1期67-78,共12页医学前沿（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(Grant No.30971138);the Science Foundation of Suzhou City(No.SWG0904 and No.SS201004);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),and a Special National Strategic Leader Project of China(No.XDA01040200).

摘　　要：Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004.Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment,recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy,resulting in tumor recurrence in patients after several months of treatment.Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues,which fosters tumor cells to become more aggressive and metastatic.In 2001,Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers.At present,normalizing the disorganized tumor vasculature,rather than disrupting or blocking them,has emerged as a new option for anticancer therapy.Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies,proteins,peptides,small molecules,and pericytes resulted in decreased tumor size and reduced metastasis.However,current tumor vascular normalizing drugs display moderate anticancer efficacy.Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization,growth,and metastasis.Therefore,multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization.To this end,the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics,as well as the integration ofWestern medicine with traditional Chinese medicine,may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.

关 键 词：ANGIOGENESIS VASCULOGENESIS NEOVASCULARIZATION TUMOR VASCULATURE NORMALIZATION traditional Chinese medicine 

分 类 号：R73[医药卫生—肿瘤]