Cannabinoids and endocannabinoids as therapeutics for nervous system disorders:preclinical models and clinical studies  

作　　者：R.Scott Duncan Sean M.Riordan Matthew C.Gernon Peter Koulen 

机构地区：[1]Department of Ophthalmology,School of Medicine,University of Missouri [2]Department of Biomedical Sciences,School of Medicine,University of Missouri

出　　处：《Neural Regeneration Research》2024年第4期788-799,共12页中国神经再生研究（英文版）

基　　金：supported in part by grants from the National Institute on Aging and National Eye Institute[EY030747(3R01EY030747-02S2)and EY031248(3R01EY03124802S1)]of the National Institutes of Health(to PK);Additional support by the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research;the Vision Research Foundation of Kansas City。

摘　　要：Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body.They have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human diseases.Some of these include central nervous system(CNS)diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric disorders.In addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal CNS function,and if controlled or modified,may represent an additional therapeutic avenue for CNS diseases.This review discusses in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CNS pathologies.In addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CNS diseases.Cannabinoids and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关 键 词：ANANDAMIDE CANNABIDIOL cannabinoid ENDOCANNABINOID epilepsy multiple sclerosis neurodegeneration neuroprotection TETRAHYDROCANNABINOL 

分 类 号：R741[医药卫生—神经病学与精神病学]