The objective of this study was to carry out a review of the literature covering the topic of the association between sleep, insomnia and the medicinal use of cannabis. The guiding question for carrying out this study...
supported in part by grants from the National Institute on Aging and National Eye Institute[EY030747(3R01EY030747-02S2)and EY031248(3R01EY03124802S1)]of the National Institutes of Health(to PK);Additional support by the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research;the Vision Research Foundation of Kansas City。
Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body.They have been studied in cellular and animal models as well as in human clinical trials for th...
supported by National Institutes of Health grants No. R01NS076815, R01MH113535, and R01AG058621。
Traumatic brain injury(TBI)is a temporary or permanent disruption of brain function caused by external forces.TBI has been recognized as an important risk factor for the development of Alzheimer’s disease and dementi...
supported by National Institutes of Health grants R01NS076815,R01MH113535,and R01AG058621(to CC).
Alzheimer’s disease(AD)is the most common cause of dementia in the elderly.Unfortunately,there are no effective therapies currently available for prevention and treatment of AD.As it is clear now,the etiology of AD i...
Morinda citrifolia (noni) fruit juice has exhibited a variety of biological activities in human clinical trials, indicating that it influences multiple systems of the body. Since the 1990s, the endocannabinoid system ...
Neurodegenerative diseases are characterized by progressive degeneration and/or death of neuronal cells and results in a wide array of cognitive impairments and other serious neurological defects. The signaling pathwa...
Morinda citrifolia (noni) fruit juice has been shown to have a wide variety of potential health benefits in human clinical trials. It may also influence the endocannabinoid system of the body. Since the main ingredien...
We recently reported that a CB2R agonist,GW405833(GW),reduced both the ACh-induced Ca^2+ oscillations and the L-arginineinduced Ca2+signal enhancement in mouse pancreatic acinar cells,suggesting that GW-induced inhibi...
Shaanxi Province Natural Science Foundation(No.2016JQ8024);International Cooperation and Exchange of the National Natural Science Foundation of China(No.81420108013).
Brain endogenous cannabinoid(eCB)signaling seems to harmonize appropriate behavioral responses,which are essential for the organism’s long-term viability and homeostasis.Dysregulation of eCB signaling contributes to ...
Endocannabinoid signaling is implicated in an array of psychopathologies ranging from anxiety to psychosis and addiction.In recent years,radiotracers targeting the endocannabinoid system have been used in positron emi...