水产品中致病与腐败菌的群体感应抑制剂研究进展  

Research Progress on Quorum Sensing Inhibitors against Pathogenic and Spoilage Bacteria in Aquatic Products

作　　者：檀茜倩 裴建博 崔方超 李秋莹 吕欣然 孙彤[1,2] 励建荣 TAN Xiqian;PEI Jianbo;CUI Fangchao;LI Qiuying;LÜXinran;SUN Tong;LI Jianrong(School of Food Science and Engineering,Bohai University,Jinzhou 121013,China;Institute of Marine Science and Technology,Bohai University,Jinzhou 121013,China;College of Food Science and Engineering,Tianjin University of Science and Technology,Tianjin 300457,China)

机构地区：[1]渤海大学食品科学与工程学院,辽宁锦州121013 [2]渤海大学海洋研究院,辽宁锦州121013 [3]天津科技大学食品科学与工程学院,天津300457

出　　处：《食品科学》2023年第19期270-278,共9页Food Science

基　　金：“十三五”国家重点研发计划重点专项(2019YFD0901702);辽宁省教育厅项目(LQ2020007)。

摘　　要：水产品因营养丰富深受消费者喜爱,但其易受细菌污染导致腐败变质,给消费者带来食用安全风险。现阶段研究证实细菌致腐和毒力的发挥多受到群体感应系统调控,因此利用群体感应抑制剂干扰细菌群体感应系统可以作为一种有效的细菌控制手段。越来越多的群体感应抑制剂在微生物、植物、动物中被发现。随着生物工程、化学信息学和纳米技术的发展,通过人工设计也合成了多种新型群体感应抑制剂。因此,本文首先概述几种常见水产品食源性致病菌和腐败菌的群体感应系统类型及其对毒力因子的调控方式,并着重从微生物源、植物源、动物源和人工合成几个角度对相应群体感应抑制剂的研究现状进行分析和总结,为基于细菌群体感应系统控制水产品质量安全提供参考。Being nutritious,aquatic products are loved by consumers.However,aquatic products are prone to bacterial spoilage,posing safety risks to consumers.The current research proves that bacterial spoilage capacity and virulence are often regulated by its quorum sensing(QS)system,so using quorum sensing inhibitors(QSIs)to intervene in the QS system is an effective way to control bacteria.Currently,more and more QSIs have been discovered from microorganisms,plants and animals.Along with the development of biological engineering,cheminformatics and nanotechnology,artificial QSIs have been synthesized.In order to provide a reference for quality and safety control of aquatic products based on QS inhibition,this article reviews the QS systems of seveal common aquatic product-borne pathogenic and spoilage bacteria and the modes of regulatory effects of the QS systems on virulence factors,with a focus on the current status of research on microbial-,plant-,animal-derived and synthetic QSIs.

关 键 词：群体感应抑制剂 食源性致病菌 腐败菌 水产品保鲜 水产品安全 

分 类 号：TS254.4[轻工技术与工程—水产品加工及贮藏工程]