食源性致病菌天然抗生物被膜剂的研究进展  

Research Progress on Natural Antimicrobial Agents for Foodborne Pathogen Biofilms

作　　者：杨昌颖 吴亦菲 谢廷怿 刘娜娜[1] 刘欣[1] 李卓思 董庆利[1] 秦晓杰 YANG Changying;WU Yifei;XIE Tingyi;LIU Nana;LIU Xin;LI Zhuosi;DONG Qingli;QIN Xiaojie(School of Health Science and Technology,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093

出　　处：《工业微生物》2023年第6期148-156,共9页Industrial Microbiology

基　　金：国家自然科学基金青年科学基金项目(32102111)。

摘　　要：食源性致病菌是罹患食源性疾病的重要诱因。在食品工业中,食源性致病菌易黏附在食品原料和加工设备表面形成生物被膜,这导致其难以被彻底清除,给公众健康带来严重威胁。近些年,研究学者不断挖掘新的天然抗生物被膜剂,如噬菌体、植物提取物、酶、抗菌肽及生物表面活性剂等,并针对这些天然抗菌剂对生物被膜的控制效果和作用机制展开了一系列研究,期望替代或弥补物理、化学方法的不足。文章研究了不同种类的天然抗生物被膜剂及其对食源性致病菌生物被膜的抑制效果,并从降低细菌表面黏附能力、调控群体感应信号通路、降解胞外聚合物组分及破坏细菌细胞膜等角度总结了天然抗菌剂抑制生物被膜的作用机制,最后对未来的研究方向提出了展望,旨在为食品工业中食源性致病菌的防控提供依据。Foodborne pathogens play a crucial role in the occurrence of foodborne diseases.They are prone to adhere to the surfaces of food ingredients and processing equipment,forming biofilms that are challenging to fully eliminate.This poses a significant threat to public health.In recent years,researchers have been exploring new natural antimicrobial agents,including bacteriophages,plant extracts,degradative enzymes,antimicrobial peptides,and biosurfactants.Numerous studies have been conducted to investigate the effects and mechanisms of these natural antimicrobial agents on biofilms,to replace or make up for the shortcomings of physical and chemical methods.This review summarized different types of natural antimicrobial agents and their inhibitory effects on biofilms formed by foodborne pathogens.It also highlighted the latest advancements in understanding the mechanisms of action employed by these natural antimicrobial agents,including reducing bacterial surface adhesion,regulating quorum sensing signal pathways,degrading extracellular polymeric substances,and disrupting bacterial cell membranes.Finally,this study offered prospects for future research directions,which will provide a basis for the prevention and control of foodborne pathogens in the food industry.

关 键 词：食源性致病菌 生物被膜 天然抗菌剂 群体感应 食品安全 

分 类 号：TS201.3[轻工技术与工程—食品科学]