山东省市售液态乳及乳粉中黄曲霉毒素M_(1)污染风险评估  

Risk Assessment of Aflatoxin M1 Contamination in Commercially Available Liquid Milk and Milk Powder in Shandong Province

作　　者：刘盼盼 肖培瑞[2] 赵金山[2] 王克波[2] 陈晨 褚遵华[2] LIU Panpan;XIAO Peirui;ZHAO Jinshan;WANG Kebo;CHEN Chen;CHU Zunhua(School of Public Health,Shandong University,Jinan 250012,China;Institute of Food and Nutrition,Shandong Center for Disease Control and Prevention,Jinan 250014,China)

机构地区：[1]山东大学公共卫生学院,山东济南250012 [2]山东省疾病预防控制中心食品与营养所,山东济南250014

出　　处：《食品安全导刊》2025年第10期76-81,91,共7页China Food Safety Magazine

摘　　要：目的:了解山东省市售液态乳及乳粉中黄曲霉毒素M_(1)(Aflatoxin M_(1),AFM_(1))污染水平,对居民经液态乳及乳粉摄入AFM_(1)的健康风险进行评估。方法:在山东省7个城市的农贸市场、商店超市和网店采集液态乳及乳粉共计676份,应用免疫亲和法和酶联免疫法进行测定,采用暴露限值法、肝癌风险法和危险指数法对山东省居民摄入AFM_(1)的潜在健康风险进行评估。结果:676份市售液态乳及乳粉中AFM_(1)平均浓度为0.02067μg·kg^(-1)。在所有年龄组人群中,2~4岁年龄组因摄入AFM_(1)导致的肝癌风险最高。具体而言,摄入液态乳的男性和女性的肝癌风险分别为0.004968、0.004669例/10万人/年,而摄入乳粉的肝癌风险为0.000069例/10万人/年。摄入市售液态乳及乳粉的AFM_(1)非致癌风险均可接受。结论:山东省市售液态乳及乳粉中AFM_(1)污染健康风险较低,但低年龄组液态乳消费人群AFM_(1)肝癌风险仍需关注。Objective:To understand the level of aflatoxin M1(AFM1)contamination in commercially available liquid milk and milk powder in Shandong province,and to assess the health risk of AFM1 intake via liquid milk and milk powder in residents.Method:A total of 676 samples of liquid milk and milk powder were collected from farmers’markets,shops supermarkets and online shops in seven cities of Shandong province,and were measured by immunoaffinity and enzyme immunoassay methods,and the potential health risk of aflatoxin M1 intake by residents of Shandong province was assessed using the margin of exposure,liver cancer risk and hazard index methods.Result:The mean concentration of AFM1 detected in 676 portions of commercially available liquid milk and milk powder was 0.02067μg·kg-1.Among all age groups,the risk of liver cancer due to AFM1 intake is highest in the 2~4 year old age group.Specifically,the liver cancer risk associated with the consumption of liquid milk is 0.004968 cases/100000 persons/year and 0.004669 cases/100000 persons/year for women and men,respectively,while the risk associated with the consumption of powdered milk is 0.000069 cases/100000 persons/year.The non-carcinogenic risk of AFM1 from intake of commercially available liquid milk and milk powder was acceptable.Conclusion:The health risk of AFM1 contamination in commercially available liquid milk and milk powder in Shandong province is low,but the health risk of AFM1 liver cancer in liquid milk consumers in the lower age groups is still a cause for concern.

关 键 词：液态乳 乳粉 黄曲霉毒素M_(1) 风险评估 

分 类 号：TS2[轻工技术与工程—食品科学与工程]