Primary prevention of posttraumatic stress disorder: drugs and implications  

作　　者：Joachim C Burbiel 

机构地区：[1]Fraunhofer Institute for Technological Trend Analysis INT, Appelsgarten 2, 53879 Euskirchen, Germany

出　　处：《Military Medical Research》2015年第3期156-162,共7页军事医学研究（英文版）

摘　　要：Because posttraumatic stress disorder(PTSD) is a highly debilitating condition, prevention is an important research topic. This article reviews possible prevention approaches that involve the administration of drugs before the traumatic event takes place. The considered approaches include drugs that address the sympathetic nervous system, drugs interfere with the hypothalamic-pituitary-adrenal(HPA) axis, narcotics and other psychoactive drugs, as well as modulators of protein synthesis. Furthermore, some thoughts on potential ethical implications of the use of drugs for the primary prevention of PTDS are presented. While there are many barriers to overcome in this field of study, this paper concludes with a call for additional research, as there are currently no approaches that are well-suited for regular daily use.Because posttraumatic stress disorder(PTSD) is a highly debilitating condition, prevention is an important research topic. This article reviews possible prevention approaches that involve the administration of drugs before the traumatic event takes place. The considered approaches include drugs that address the sympathetic nervous system, drugs interfere with the hypothalamic-pituitary-adrenal(HPA) axis, narcotics and other psychoactive drugs, as well as modulators of protein synthesis. Furthermore, some thoughts on potential ethical implications of the use of drugs for the primary prevention of PTDS are presented. While there are many barriers to overcome in this field of study, this paper concludes with a call for additional research, as there are currently no approaches that are well-suited for regular daily use.

关 键 词：Posttraumatic stress disorder Prevention Pre-treatment PROPRANOLOL PRAZOSIN KETAMINE MORPHINE ANISOMYCIN Osanetant 

分 类 号：R749.5[医药卫生—神经病学与精神病学]