ANISOMYCIN

作品数：8被引量：24H指数：3
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相关作者：王群张家玉李宏莲刘世杰李卓更多>>
相关机构：暨南大学华中科技大学内蒙古医科大学内蒙古医科大学附属医院更多>>
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Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway被引量：4
《Acta Pharmacologica Sinica》2020年第4期561-571,共11页Yu-han Zhang Ya-qin Zhang Cong-cong Guo Li-kang Wang Yu-jiao Cui Jian-jun Dong Lin Liao 
funded by National Natural Science Foundation of China(81670757,81570742);the Shandong Provincial Natural Science Foundation(ZR2016HQ26);the Grant for the Development of Science and Technology of Ji-nan City(201602172).
Proximal renal tubular damage is a critical process underlying diabetic kidney disease(DKD).Our previous study shows that prostaglandin E1(PGE1)reduces the apoptosis of renal tubular cells in DKD rats.But its underlyi...
关键词：Diabetic kidney disease PROXIMAL renal TUBULAR CELLS prostaglandin E1 apoptosis JNK/Bim HK-2 PROXIMAL TUBULAR CELLS ANISOMYCIN SP600125 
A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var.beijingensis被引量：11
《Synthetic and Systems Biotechnology》2019年第1期40-48,共9页Jufang Shen Lingxin Kong Yan Li Xiaoqing Zheng Qing Wang Weinan Yang Zixin Deng Delin You 
the National Natural Science Foundation of China(31630002,31700029,31770038,31470183,21661140002 and 31170085);the Ministry of Science and Technology,China;Shanghai Pujiang Program from the Shanghai Municipal Council of Science and Technology(12PJD021);China Postdoctoral Science Foundation(2017M620151).
The protein synthesis inhibitor anisomycin features a unique benzylpyrrolidine system and exhibits potent selective activity against pathogenic protozoa and fungi.It is one of the important effective components in Agr...
关键词：ANISOMYCIN Agricultural Antibiotic120 BIOSYNTHESIS AniF LuxR regulator STREPTOMYCES 
JNK被抑制后LPS对皮肤成纤维细胞增殖的作用机制被引量：1
《中国生物制品学杂志》2019年第1期33-35,共3页王永祥 王春燕 赵鹏伟 
内蒙古自然科学基金(2017MS08116);内蒙古自治区教育厅基金支持(NJZC16115)
目的抑制JNK通路后,分析LPS对皮肤成纤维细胞的作用。方法用400 ng/mL JNK磷酸化激动剂Anisomycin和20 ng/mL脂多糖(lipopolysaccharide,LPS)同时作用于皮肤成纤维细胞,并设LPS单独作用组,MTT法检测作用0、24、48和72 h时的细胞生长率,W...
关键词：皮肤成纤维细胞 增殖 脂多糖 JNK通路 抑制 ANISOMYCIN 
Primary prevention of posttraumatic stress disorder: drugs and implications被引量：1
《Military Medical Research》2015年第3期156-162,共7页Joachim C Burbiel 
Because posttraumatic stress disorder(PTSD) is a highly debilitating condition, prevention is an important research topic. This article reviews possible prevention approaches that involve the administration of drugs b...
关键词：Posttraumatic stress disorder Prevention Pre-treatment PROPRANOLOL PRAZOSIN KETAMINE MORPHINE ANISOMYCIN Osanetant 
Anisomycin induces glioma cell death via downregulation of PP2A catalytic subunit in vitro被引量：1
《Acta Pharmacologica Sinica》2012年第7期935-940,共6页Jun-yang LI Jia-yuan HUANG Meng LI Han ZHANG Biao XING Gong CHEN Dong WEI Pei-yuan GU Wei-xing HU 
We thank Professor Kun YAO for providing the U251 and U87 human glioblastoma cell line. This work was supported by grants from the Jiangsu Province Natural Science Foundation （No BK2007257）.
Aim： To examine the effects of anisomycin on glioma cells and the related mechanisms in vitro. Methods： The U251 and U87 human glioblastoma cell lines were tested. The growth of the cells was analyzed using a CCK-8 ...
关键词：ANISOMYCIN GLIOMA apoptosis p38 MAPK JNK protein phosphatase 2A 
Concise synthesis of (-)-anisomycin
《Chinese Chemical Letters》2012年第6期647-649,共3页Ji Li Yan Hua Feng Xin Bai Li Wei Han Huan Qiu Liu Guo Guang Shao 
support from The First Hospital of Jilin University
The antibiotic （-）-anisomycin was synthesized starting from D-tyrosine using Sharpless asymmetric epoxidation as a key reaction followed by formation and hydrolysis of oxazoline set up all chiral center.
关键词：ANISOMYCIN D-Tyrosine Sharpless asymmetric epoxidation OXAZOLINE 
Anisomycin诱导小鼠艾氏腹水癌细胞凋亡被引量：1
《现代生物医学进展》2011年第15期2864-2867,共4页尤朋涛 邢飞跃 唐征乐 李卓 
国家自然科学基金项目(30471635;30971465);中央高校基础研究基金(21610608);"211工程"基金项目(2009)
目的:探讨Anisomycin诱导EAC细胞凋亡的机制。方法:利用MTT法观察Anisomycin对EAC细胞增殖的影响;应用AnnexinV-FITC和PI双染色检测Anisomycin作用下EAC细胞凋亡的变化;琼脂糖凝胶电泳检测Anisomycin作用下EAC细胞的DNA断裂片断;采用RT-...
关键词：ANISOMYCIN 细胞凋亡 艾氏腹水癌 
Anisomycin过度激活丝裂原活化蛋白激酶使tau发生过度磷酸化(英文)被引量：6
《生理学报》2008年第4期485-491,共7页王群 张家玉 刘世杰 李宏莲 
the National Natural Science Foundation of China (No. 30772292)
阿尔茨海默病(Alzheimer’s disease,AD)的病理特征之一是神经元内存在神经原纤维缠结(neurofibrillary tangles,NFTs),后者是由过度磷酸化的微管相关蛋白tau形成的双股螺旋细丝(pairedhelical filaments,PHFs)构成。为了探讨丝裂原活...
关键词：阿尔茨海默病 丝裂原活化蛋白激酶 TAU蛋白 磷酸化 糖原合酶激酶-3 蛋白激酶A 
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