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Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent MraY inhibitors as antibacterial agents
《Chinese Chemical Letters》2025年第2期1-3,共3页Mianling Yang Meehyein Kim Peng Zhan 
Despite the availability of effective antibacterial drugs,the increasing prevalence of antibiotic-resistant bacteria is primarily attributed to their excessive and inappropriate utilization.Antimicrobial resistance(AM...
关键词：holds SYNTHESIS attributed 
Revealing drug targets with multimodal bioorthogonal AMPD probes through visual metabolic labeling
《Chinese Chemical Letters》2024年第12期405-410,共6页Fukui Shen Yuqing Zhang Guoqing Luan Kaixue Zhang Zhenzhen Wang Yunhao Luo Yuanyuan Hou Gang Bai 
supported by the National Key Research and Development Program of China(Nos.2022YFC3500800 and2022YFC3500805)。
Multimodal bioorthogonal small molecule probes play a pivotal role in drug-focused biomedical research.However,existing drug tracking and imaging techniques face obstacles in living organisms,hindering precise drug lo...
关键词：Multimodal bioorthogonal probe Bioorthogonal reactions Photoclick IN-SITU Drug tracking 
Cu-catalyzed three-component C–S–P coupling for the synthesis of trisubstituted allenyl phosphorothioates
《Chinese Chemical Letters》2024年第12期462-465,共4页Bowen Wang Longwu Sun Qianqian Cao Xinzhi Li Jianai Chen Shizhao Wang Miaolin Ke Fener Chen 
supported by the Educational Foundation of Zhejiang University of Technology(No.KYY-HX-20220471)。
A copper-catalyzed three-component reaction involving cyclic carbonates,elemental sulfur,and H-phosphonates is presented.It proceeds with excellent yields and provides an attractive approach for the construction of va...
关键词：Cu-catalyzed Construction of C–S–P bond Three-component reaction Elemental sulfur Allenyl phosphorothioates 
neo-Dicitrinols A–C:Unprecedented PKS-NRPS hybrid citrinin dimers with ferroptosis inhibitory activity from the deep-sea-derived Penicillium citrinum W22
《Chinese Chemical Letters》2024年第12期466-469,共4页Zheng-Biao Zou Tai-Zong Wu Chun-Lan Xie Yuan Wang Yan Li Gang Zhang Rong Chao Lian-Zhong Luo Li-Sheng Li Xian-Wen Yang 
financially supported by the Xiamen Southern Oceanographic Center(No.22GYY007HJ07)。
The chemical investigation into the EtOAc extract of the deep-sea-derived fungus Penicillium citrinum W22 yielded three unprecedented citrinin dimers,neo-Dicitrinols A–C(1–3)and a known one,penicitrinone A(4).Their ...
关键词：DEEP-SEA Fungus Citrinin dimers PKS-NRPS hybrid Ferroptosis 
Holotrichones A and B,potent anti-leukemic lindenane-type sesquiterpene trimers with unprecedented complex carbon skeletons from a rare Chloranthus species
《Chinese Chemical Letters》2024年第12期470-474,共5页Xue-Jiao Wang Jun-Li Xin Hong Xiang Ze-Yu Zhao Yu-Hang He Haibo Wang Guangyao Mei Yi-Cheng Mao Juan Xiong Jin-Feng Hu 
supported by grants from the National Natural Science Foundation of China(Nos.21772025,21937002)。
Two lindenane-type sesquiterpene(LDS)trimers with unprecedented carbon skeletons,holotrichones A(1)and B(2),were obtained from the whole plant of Chloranthus holostegius var.trichoneurus by a ultra performance liquid ...
关键词：Chloranthus holostegius var.trichoneurus Holotrichones Lindenane-type sesquiterpene trimers Acute myeloid leukemia Cell apoptosis 
Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment
《Chinese Chemical Letters》2024年第12期180-185,共6页Tong Tong Lezong Chen Siying Wu Zhong Cao Yuanbin Song Jun Wu 
support of the National Natural Science Foundation of China(Nos.52173150,52073313);the Guangzhou Science and Technology Program City-University Joint Funding Project(No.2023A03J0001);the Shenzhen Science and Technology Program(No.KCXFZ 202002011010232)。
Colorectal cancer is a common cancer worldwide.Traditional chemotherapeutic drugs often face limitations such as poor aqueous solubility and high systemic toxicity,which can lead to adverse side effects and limited th...
关键词：Leucine-based poly(ester amide)s STRUCTURE-PROPERTY Nanoplatform Drug delivery Colorectal cancer 
Advances in synthetic biology-based drug delivery systems for disease treatment
《Chinese Chemical Letters》2024年第11期66-73,共8页Yujie Li Ya-Nan Wang Yin-Gen Luo Hongcai Yang Jinrui Ren Xiao Li 
With the increasing demand for personalized and precise treatment,the rapid advancement of synthetic biology technology has inevitably led to the development of nanobiology-based drug delivery systems.Synthetic biolog...
关键词：Drug delivery system Synthetic biology NANOTECHNOLOGY Genetic engineering NANOPARTICLES 
Design,synthesis and evaluation of the first DYRK1A degrader for promoting the proliferation of pancreaticβ-cells
《Chinese Chemical Letters》2024年第11期430-434,共5页Yueying Yang Huiru Xie Xinbo Yu Yang Liu Hui Wang Hua Li Lixia Chen 
the National Natural Science Foundation of China(NSFC,No.82141216);Chunhui Program-Cooperative Research Project of the Ministry of Education;Liaoning Province Natural Science Foundation(No.2022-MS-241);Shenyang Young and Middle-aged Innovative Talents Support Program(No.RC210446);“Select the best candidates to lead key research projects”of Fujian University of Traditional Chinese Medicine(No.XJB2022008);Foundation of Fujian University of Traditional Chinese Medicine(No.X2023001-Talent);the support from National-Local Joint Engineering Research Center for Molecular Biotechnology of Fujian&Taiwan TCM;at Fujian University of Traditional Chinese Medicine。
Dual-specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A)is the most promising target for diabetes treatment by promotingβ-cell proliferation.The desmethylbellidifolin(DMB)as a DYRK1A inhibitor could faci...
关键词：PROTAC DYRK1A Degraders Desmethylbellidifolin β-Cell proliferation 
FDA approved fluorine-containing drugs in 2023
《Chinese Chemical Letters》2024年第11期111-122,共12页Qian Wang Yeping Bian Gagan Dhawan Wei Zhang Alexander E.Sorochinsky Ata Makarem Vadim A.Soloshonok Jianlin Han 
support from the National Natural Science Foundation of China (No.21761132021);the Qing-Lan Project of Jiangsu Province (for Han) and IKERBASQUE,Basque Foundation for Science (for Soloshonok)。
This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023.These small molecule drugs represent such therapeutic areas as cancer,neuromuscular dis...
关键词：Fluorine-containing compounds Blockbuster drugs Pharmaceuticals ANTI-CANCER Drug design and development Asymmetric synthesis 
Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy
《Chinese Chemical Letters》2024年第10期278-285,共8页Linjie Ju Zhongxi Huang Qian Shen Chan Fu Shuanghe Li Wenjie Duan Chenfeng Xu Weizhen An Zhiqiang Zhai Jifu Wei Changmin Yu Guoren Zhou 
supported by the National Key R&D Program of China(No.2020YFA0709900);the Excellent Postdoctoral Program of Jiangsu Province(No.2022ZB803);National Natural Science Foundation of China(No.82273162);the major science and technology program of Nanjing(No.202305027);the Open Program of NHC Key Laboratory of Nuclear Medicine and Jiangsu Key Laboratory of Molecular Nuclear Medicine(No.KF202203)。
The occurrence of acquired resistance to cisplatin(DDP)that induces the toxic drug effects has always been a huge challenge and urgently needs to be resolved in the cancer treatment.The combination of anticancer drugs...
关键词：MON_(ptse) NSCLC Glutathione depletion Responsive biodegradation Traditional Chinese medicines Synergistictherapy 
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