Supported by National Natural Science Foundation of China (Grant No. 30370798, 30571034 and 30570424);National High-Tech Research and Development Program of China (Grant No. 2007AA02Z329);National Basic Research Program of China (Grant No. 2008CB517302); Natural Science Foundation of Heilongjiang Province, China (Grant No. ZJG0501, 1055HG009, GB03C602-4 and BMFH060044); New Century Hundred-Thousand-Ten Thousand Talents Project of Beijing City, Scientific Research Common Program of Beijing Municipal Commission of Education (KM200610025011).
Proteins rarely function in isolation inside and outside cells, but operate as part of a highly intercon- nected cellular network called the interaction network. Therefore, the analysis of the properties of drug-targe...