国家重点基础研究发展计划(2007CB512403)

作品数:5被引量:34H指数:2
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相关作者:曹雪涛更多>>
相关机构:第二军医大学更多>>
相关期刊:《中国基础科学》《Cellular & Molecular Immunology》《Cell Research》更多>>
相关主题:DENDRITIC_CELLSINDUCINGGENE-MODIFIEDIMMUNOSUPPRESSIVETGF-更多>>
相关领域:医药卫生生物学农业科学化学工程更多>>
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Immunosuppressive exosomes from TGF-pl gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells被引量:22
《Cell Research》2012年第3期607-610,共4页Zhijian Cai Wei Zhang Fei Yang Lei Yu Zhou Yu JihHung Pan Lie Wang Xuetao Cao Jianli Wang 
Acknowledgments We thank Ms Diya Yang for technical assistance. This work was supported by the National Key Basic Research Program of China (2007CB512403), the National Natural Science Foundation of China (30972725 and 31070795), the National Technology Key Projects of China (008ZX1002-008) and the Natural Science Foundation of Zhejiang Province (Z2090042).
Dear Editor, Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally believed to originate from the complicated interactions between genetic factors and commensal flora. Thi...
关键词:调节性T细胞 自身免疫性疾病 树突状细胞 免疫抑制 基因修饰 炎症 溃疡性结肠炎 介导 
Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells被引量:9
《Cellular & Molecular Immunology》2012年第3期267-275,共9页Zhenli Hu Ruohua Chen Zhijian Cai Lei Yu Yang Fei Lixia Weng Jinghan Wang Xiahui Ge Tianyi Zhu Jianli Wang Chong Bai 
Salmeterol is a long-acting β2-agonist that activates adenylate cyclase, causing long-lasting bronchodilation and has been used for many years to control asthma. However, little information is available about the imm...
关键词:ASTHMA dendritic cells pro-inflammatory cytokines SALMETEROL 
E3泛素连接酶Nrdp1优先促进TLR介导的Ⅰ型干扰素产生被引量:1
《中国基础科学》2010年第3期21-23,共3页曹雪涛 
国家973计划项目(2007CB512403);国家自然科学基金(30721091;30572122;30771118);国家优博论文基金(200775);上海市科学技术委员会基金(06DJ14011;07QA14067)
E3泛素连接酶对于固有免疫和获得性免疫非常重要。我们发现E3泛素连接酶Nrdp1通过抑制MyD88依赖的转录因子NF-κB和AP-1的活性并促进激酶TBK1和转录因子IRF3的活性,进而抑制Toll样受体诱发的促炎症细胞因子的产生,但增加了巨噬细胞的干...
关键词:TOLL样受体 E3泛素连接酶 Ⅰ型干扰素 MYD88 TBK1 炎症 
Cloning and Characterization of DULP,a Novel Ubiquitin-Like Molecule from Human Dendritic Cells
《Cellular & Molecular Immunology》2009年第1期27-33,共7页Guoyan Liu Shuxun Liu Ping Li Ling Tang Yanmei Han Huazhang An Jiangyan Li Xiankun Dai Nan Li Xuetao Cao Yizhi Yu 
supported by grants from the National Key Basic Research Program of China (2004CB518807, 2007CB512403);the National Natural Science Foundation of China (30772004, 30121002, 30600539);the Natural Science Foundation of Shanghai (06QA14069).
We identified a novel ubiquitin-like molecule DULP from human dendritic cells. DULP contains a domain that shares 26% identity and 34% similarity with ubiquitin, and it possesses the corresponding Ile-44 hydrophobic p...
关键词:ubiquitin-like protein dendritic cell molecular cloning APOPTOSIS 
Albaconol,a Plant-Derived Small Molecule,Inhibits Macrophage Function by Suppressing NF-κB Activation and Enhancing SOCS1 Expression被引量:2
《Cellular & Molecular Immunology》2008年第4期271-278,共8页Qiuyan Liu Xiaoli Shu Li Wang Anna Sun Jikai Liu Xuetao Cao 
grants from the National Natural Science Foundation of China (30721091);the National Key Basic Research Program of China (2007CB512403)
Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention these years. Albaconol is a new kind of small compound, prenylated resorcinol, isolated from the...
关键词:IMMUNOSUPPRESSANT MACROPHAGE proinflammatory cytokine NF-ΚB SOCS 1 
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