国家自然科学基金(s31170717)

作品数：2被引量：2H指数：1
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相关期刊：《Acta Biochimica et Biophysica Sinica》更多>>
相关主题：PRIONDISTINCTCU^2+AFFINITYTSE更多>>
相关领域：农业科学环境科学与工程更多>>
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Distinct effects of Cu^2＋-binding on oligomerization of human and rabbit prion proteins被引量：2
《Acta Biochimica et Biophysica Sinica》2015年第10期842-850,共9页Kejiang Lin Ziyao Yu Yuanhui Yu Xinli Liao Pei Huang Chenyun Guo Donghai Lin 
This work was supported by the grants from the National Natural Science Foundation of China （Nos. 31170717, 31470034, and 31270777）.
The cellular prion protein （PrP^C） is a kind of cell-surface Cu^2＋-binding glycoprotein. The oligomerization of PrP^C is highly related to transmissible spongiform encephalopathies （TSEs）. Cu^2＋ plays a vital ro...
关键词：Cu^2＋ prion oligomerization AFFINITY conformational stability TSE-resistance 
Prion protein oligomer and its neurotoxicity
《Acta Biochimica et Biophysica Sinica》2013年第6期442-451,共10页Pei Huang Fulin Lian Yi Wen Chenyun Guo Donghai Lin 
Funding This work was supported by the grants from the National Natural Science Foundation of China （Nos. 31170717, 91129713, and 30900233）.
The prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders. According to the ＇protein only＇ hypothesis, the key molecular event in the pathogenesis of priori d...
关键词：PRION OLIGOMER NEUROTOXICITY transmissiblespongiform encephalopathies 
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