国家自然科学基金(30370712)

作品数:9被引量:74H指数:5
导出分析报告
相关作者:何大澄肖雪媛张丽娟黄凌云戴嵩玮更多>>
相关机构:北京师范大学中国人民解放军西安交通大学医学院第二附属医院更多>>
相关期刊:《Science China(Life Sciences)》《Biomedical and Environmental Sciences》《中华结核和呼吸杂志》更多>>
相关主题:LUNG_CANCERLUNG蛋白质芯片标志分子SELDI-TOF-MS更多>>
相关领域:医药卫生生物学更多>>
-

检索结果分析

结果分析中...
条 记 录,以下是1-9
视图:
排序:
一个在肺癌血清中高表达的标志分子SAA的发现及鉴定被引量:25
《中国科学(C辑)》2007年第2期129-134,共6页戴嵩玮 王小敏 刘丽云 刘吉福 武珊珊 黄凌云 肖雪媛 何大澄 
973项目(编号:2006CB910100);国家自然科学基金(批准号:30370712);北京科委项目(批准号:Y0204002040111);北京市自然科学基金重点项(批准号:7051002)资助
应用表面增强基质辅助激光解析离子化-飞行时间质谱(SELDI-TOF-MS)对175例肺癌病人和43例正常人血清进行了蛋白质谱检测.通过Biomarker Wizard^(TM)和Biomarker Patterns^(TM)软件分析显示11.6kD蛋白峰在肺癌病人血清中明显高于正常对照...
关键词:肺癌 血清淀粉样蛋白(serum AMYLOID A protein SAA) 表面增强基质辅助激光解析飞行时间质谱(SELDI-TOF-MS) 
Discovery and identification of Serum Amyloid A protein elevated in lung cancer serum被引量:10
《Science China(Life Sciences)》2007年第3期305-311,共7页DAI SongWei1,2, WANG XiaoMin1,2, LIU LiYun1,2, LIU JiFu3, WU ShanShan3, HUANG LingYun1,2, XIAO XueYuan1,2 & HE DaCheng1,2 1 Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Beijing Normal University, Beijing 100875, China 2 Universities’ Confederated Institute of Proteomics, Beijing 100875, China 3 Department of Thoracic Surgery, General Hospital of Beijing Unit, PLA, Beijing 100500, China 
the Major State Basic Research Program of China (Grant No. 2006CB910100);National Natural Science Foundation of China (Grant No. 30370712);Natural Science Foundation of Beijing (Grant No. 7051002);Sci-ence Technology Committee of Beijing (Grant No.Y0204002040111)
Two hundred and eighteen serum samples from 175 lung cancer patients and 43 healthy individuals were analyzed by using Surface Enhaced Laser Desorption/Ionization Time of Flight Mass Spectrome- try (SELDI-TOF-MS). The...
关键词:LUNG Discovery and identification of Serum Amyloid A protein elevated in lung cancer serum 
采用蛋白质组学技术筛选与肺腺癌转移相关的标志蛋白被引量:4
《现代仪器》2007年第1期26-29,共4页田甜 郝佳 徐安健 肖雪媛 何大澄 
国家自然科学基金(批准号:30370712);北京市自然基金重点项目(批准号:7051002);北京科委项目(批准号:Y0204002040111)资助
本文应用表面增强基质辅助激光解析离子化-飞行时间质谱(SELDI-TOF-MS)对一系列转移能力递增的肺腺癌细胞CL1-0,CL1-2,CL1-3 CL1--5和CL1-5F4进行蛋白质谱检测。采用H4和WCX2两种具有表面修饰的蛋白芯片筛选差异蛋白,Biomarker Wizard...
关键词:肺腺癌 标志分子 SELDI-TOF-MS 
Protein Profile of Human Lung Squamous Carcinoma Cell Line NCI-H226被引量:2
《Biomedical and Environmental Sciences》2007年第1期24-32,共9页HAO ZHANG NA LI YUE CHEN LING-YUN HUANG YI-CHING WANG GANG FANG DA-CHENG HE XUE-YUAN XIAO 
This work was supported by the National Natural Science Foundation of China (Grant No.30370712);Beijing Key Project (Grant No. 7051002).
Objective To construct a database of human lung squamous carcinoma cell line NCI-H226 and to facilitate discovery of novel subtypes markers of lung cancer. Method Proteomic technique was used to analyze human lung squ...
关键词:Lung squamous carcinoma NCI-H226 cell line PROTEOMICS Two-dimensional datapase 
Serum Amyloid A Protein: A Potential Biomarker Correlated With Clinical Stage of Lung Cancer被引量:12
《Biomedical and Environmental Sciences》2007年第1期33-40,共8页DAN-HUI LIU XIAO-MIN WANG LI-JUAN ZHANG SONG-WEI DAI LI-YUN LIU JI-FU LIU SHAN-SHAN WU SHUAN-YING YANG SAM FU XUE-YUAN XIAO DA-CHENG HE 
This work was supported by the National Natural Science Foundation of China (Grant No.30370712);Beijing Key Project (Grant No. 7051002); Beijing Science Technology Committee Project (No.Y0204002040111);a grant of Majon State Basic Research Program of China (No. 2006CB 910100).
Objective To identify serum diagnosis or progression biomarkers in patients with lung cancer using protein chip profiling analysis. Method Profiling analysis was performed on 450 sera collected from 213 patients with ...
关键词:Lung cancer Serum amyloid A On chip identification Surface enhanced laser desorption/ionization BIOMARKER 
用蛋白质芯片技术筛选非小细胞肺癌患者血清中标志蛋白被引量:20
《中华结核和呼吸杂志》2006年第1期31-34,共4页杨拴盈 肖雪媛 张王刚 孙秀珍 张丽娟 张潍 周斌 杨德昌 何大澄 
国家自然科学基金资助项目(30370712);国家高技术研究发展计划基金资助项目(2002AA232031);陕西省科技攻关资助项目(2004K13-G3)
目的探讨用蛋白质芯片技术检测血清非小细胞肺癌(NSCLC)标志蛋白筛查肺癌患者的可行性。方法用蛋白质芯片表面增强激光解吸电离飞行时间质谱仪(SELD I-TOF-MS)技术检测123例肺癌患者和40名正常人血清蛋白质质谱。用数字表法随机抽取94...
关键词: 非小细胞肺 蛋白质组 遗传筛选 
肺癌病人血清中U1-AsnRNP自身抗体的发现与鉴定被引量:3
《中国科学(C辑)》2005年第5期446-451,共6页张丽娟 刘吉福 张颢 武珊珊 黄凌云 何大澄 肖雪媛 
国家自然科学基金项目(批准号:30370712);863项目(批准号:2002AA232031)资助
许多研究表明,肺癌病人存在自身免疫现象.为了寻找肺癌病人血清中具有潜在诊断价值的自身抗体,采用免疫荧光染色,免疫印迹和蛋白质芯片技术对10例肺癌病人和10例正常人血清进行了检测.筛选中发现1例来自64岁男性肺鳞癌(Ⅲb期)病人的血...
关键词:肺癌 血清 自身抗体 U1-A SNRNP 人血清 癌病 细胞核蛋白 自身免疫 鉴定 
Discovery and identification of anti-U1-A snRNP antibody in lung cancer
《Science China(Life Sciences)》2005年第6期641-647,共7页ZHANG Lijuan1, LIU Jifu2, ZHANG Hao1, WU Shanshan2, HUANG Lingyun1, HE Dacheng1 & XIAO Xueyuan1 1. Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Beijing Normal University, Beijing 100875, China 2. Department of Thoracic Surgery, General Hospital of Beijing Unit, PLA, Beijing 100700, China 
This work was supported by the National Natural Science Foundation of China(Grant No.30370712);863 Project(Grant No.2002AA232031).
There are multiple reports of autoimmune response in patients with lung cancer. To investigate whether a novel autoantibody is present in patients with lung cancer and evaluate its clinical diagnostic and prognostic v...
关键词:LUNG cancer  autoantibody  U1-A snRNP. 
体外培养的不同亚型肺癌细胞株差异蛋白的初步分析被引量:10
《现代仪器》2004年第1期13-16,12,共5页夏梁 蔡伟丽 张丽娟 孙一娜 肖雪媛 何大澄 
教育部科学技术重点(批准号:272006)资助项;国家自然科学基金(批准号:30370712)资助项目;国家"863"(批准号:2002AA232031)资助项目
分析体外培养的不同亚型肺癌细胞株蛋白质表达差异,筛选肺癌细胞的标志蛋白并与肺癌病人血清中的标志蛋白进行对比分析。采用SELDI(Surface Enhanced LaserDesorption/Ionization)蛋白质芯片技术检测了三种肺癌细胞株A549(肺癌)、Calu-6...
关键词:蛋白质芯片 肺癌细胞株 差异蛋白 体外培养 SELDI 蛋白质谱 
检索报告 对象比较 聚类工具 使用帮助 返回顶部