国家自然科学基金(21372133)

作品数：6被引量：27H指数：4
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相关作者：张燕张丽媛王宝雷李正名李永红更多>>
相关机构：南开大学更多>>
相关期刊：《化学学报》《高等学校化学学报》《Chinese Journal of Chemistry》《Chinese Chemical Letters》更多>>
相关主题：DERIVATIVESTRIAZOLE1,2,4-TRIAZOLEPIPERAZINEMOIETIES更多>>
相关领域：理学化学工程更多>>
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Synthesis,crystal structure and 3D-QSAR studies of antifungal (bis-) 1,2,4-triazole Mannich bases containing furyl and substituted piperazine moieties被引量：4
《Chinese Chemical Letters》2018年第3期441-446,共6页Yan Zhang Yi-Zhou Zhan Yi Ma Xue-Wen Hua Wei Wei Xiao Zhang Hai-Bin Song Zheng-Ming Li Bao-Lei Wang 
supported by the National Natural Science Foundation of China(No. 21372133);Tianjin Natural Science Foundation(No. 17JCYBJC19900)
A series of novel title compounds 6a-6r and 7a-7c have been synthesized by Mannich reaction of the new triazole Schiff base intermidiates, substituted piperazine and formaldehyde under mild conditions in excellent yie...
关键词：Triazole Furan-2-yl Mannich base Antifungal activity Herbicidal activity 3D-QSAR 
Design,synthesis and insecticidal activities of novel anthranilic diamides containing fluorinated groups as potential ryanodine receptors activitors
《Chinese Chemical Letters》2017年第6期1248-1251,共4页Chang-Chun Wu Bao-Lei Wang Jing-Bo Liu Wei Wei Yu-Xin Li Yang Liu Ming-Gui Chen Li-Xia Xiong Na Yang Zheng-Ming Li 
financially supported by the National Natural Science Foundation of China(No.21372133);973 Program(No.2010CB126106);"111" Project of Ministry of Education of China(No.B06005)
In order to search for novel potent and environmentally benign insecticides,a series of anthranilic diamides containing various fluorinated groups were designed and synthesized.Their structures were confirmed by -1H N...
关键词：Anthranilic diamides Fluorinated moieties Insecticidal activities Structure-activity relationship Synthesis 
新型含取代哌嗪的5-(吡啶-3-基)-1,2,4-三唑Mannich碱和双Mannich碱的合成及生物活性被引量：11
《高等学校化学学报》2016年第6期1100-1107,共8页张燕 王宝雷 詹益周 张丽媛 李永红 李正名 
国家自然科学基金(批准号:21372133);高等学校学科创新引智计划项目(批准号:B06005)资助~~
根据药物分子设计的活性基团组合原理,通过在1,2,4-三唑环的5位引入吡啶基,同时在4位芳基亚甲氨基的苯环上引入氟或三氟甲基,设计合成了一系列含氟、吡啶和哌嗪基团的1,2,4-三唑Mannich碱和双Mannich碱类化合物.通过核磁共振氢谱(~1H N...
关键词：吡啶 1 2 4-三唑Mannich碱 哌嗪 生物活性 
Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives被引量：4
《Chinese Chemical Letters》2016年第1期163-167,共5页Li-Yuan Zhang Bao-Lei Wang Yi-Zhou Zhan Yan Zhang Xiao Zhang Zheng-Ming Li 
supported by the National Natural Science Foundation of China (No. 21372133);‘‘111’’ Project of Ministry of Education of China (No. B06005)
A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields...
关键词：Triazole thione derivatives FLUORINE PIPERAZINE Mannich base Biological activity 
Synthesis of Osthole Derivatives with Grignard Reagents and Their Larvicidal Activities on Mosquitoes被引量：5
《Chinese Journal of Chemistry》2015年第12期1353-1358,共6页Ming Liu Yang Liu Xuewen Hua Changchun Wu Sha Zhou Baolei Wang Zhengming Li 
This work was financially supported by the National Natural Science Foundation of China （Nos. 21272129 and 21372133） and ＂111＂ Project of Ministry of Educa- tion of China （No. B06005）. We also thank Prof. Er-Cai Shang and Dr. Yan-Jun Guo for their kind advices.
The structure of osthole has been modified to improve its larvicidal activity against mosquitoes. A new efficient synthesis of osthole derivatives with Grignard reagents has been developed, which employs CuI and LiCI ...
关键词：osthole derivatives mosquito larvicide Grignard reagents synthesis promoter 
基于Ugi反应的含芳氨基甲酰基1-氰基-1-环丙烷甲酰胺类新化合物的合成、结构和生物活性研究被引量：3
《化学学报》2015年第11期1173-1181,共9页詹益周 王宝雷 张丽媛 张燕 张晓 李正名 宋海斌 
国家自然科学基金面上项目(No.21372133);高等学校学科创新引智计划(No.B06005)资助~~
酮醇酸还原异构酶(KARI;EC 1.1.1.86)是植物和微生物(细菌、真菌)体内支链氨基酸生物合成过程中起催化作用的关键酶之一,可作为设计除草剂或杀菌剂的靶标.本工作在前期工作基础上,以1-氰基-1-环丙烷甲酸,芳基异腈,醛和胺为反应物,通过Ug...
关键词：环丙烷甲酰胺 Ugi反应 酮醇酸还原异构酶 抑菌活性 
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