国家自然科学基金(973Program)

作品数:95被引量:595H指数:11
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Sensitivity analysis of mesoscale structural parameters for simulation of fluidized beds被引量:1
《Particuology》2019年第6期77-93,共17页Wenming Liu Hongzhong Li Qingshan Zhu Chaoquan Hu 
The authors are grateful to the financial support from National Natural Science Foundation of Chinaunder GrantNo.21325628 and from the State Key Development Program for Basic Researchof China(973 Program)under Grant 2015CB251402.
This study presents new numerical drag models with which to analyze the sensitivity of mesoscale structural parameters in bubbling,turbulent,and circulating fluidized beds.The drag models are derived using the method ...
关键词:FLUIDIZATION SIMULATION Sensitivity analysis Dense phase Drag 
NIR-II light activated photodynamic therapy with proteincapped gold nanoclusters被引量:4
《Nano Research》2018年第10期5657-5669,共13页Qian Chen Jiawen Chen Zhijuan Yang Lin Zhang Ziliang Dong Zhuang Liu 
This article was partially supported by the National Basic Research Programs of China (973 Program) (No. 2016YFA0201200), the National Natural Science Foundation of China (No. 51525203), Collaborative Innovation Center of Suzhou Nano Science and Technology, and a Project Funded by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.
The use of near-infrared (NIR) light for photodynamic therapy (PDT) is a promising strategy to circumvent the limitations of current PDT, in which visible light with limited tissue penetration depth is usually use...
关键词:gold nanoclusters the second near-infrared (NIR-II) light photodynamic therapy tumor hypoxia cancer theranostics 
Palladium(o)-Catalyzed Si-Si Bond Insertion by the Terminal Nitrogen of Diazo Compoundst
《Chinese Journal of Chemistry》2018年第10期945-949,共5页Zhenxing Liu Tianren Fu Jingfeng Huo Sheng Feng Jianbo Wang 
The project is supported by the National Basic Research Pro- gram of China (973 Program, No. 2015CB856600) and the Natio- anal Natural Science Foundation of China (Grant 21332002, 21472004).
The palladium(o)-catalyzed nitrogen insertion into cyclic Si-Si bonds has been realized by using N-tosylhydrazones/diazo compounds as the nitrogen source. The palladium(Ⅱ) nitrene formation and subsequent migrato...
关键词:INSERTION diazo compounds Si-Si bond palladium catalysts palladium(Ⅱ) nitrene CARBENES 
Recombinant Tissue Plasminogen Activator-conjugated Nanoparticles Effectively Targets Thrombolysis in a Rat Model of Middle Cerebral Artery Occlusion被引量:3
《Current Medical Science》2018年第3期427-435,共9页Jun DENG Heng MEI Wei SHI Zhi-qing PANG Bo ZHANG Yao GUO Hua-fang WANG Xin-guo JIANG Yu HU 
This work was supported by the National Basic Scientific Research Program of China (973 Program, No. 2007CB935803), the National Natural Science Foundation of China (No. 30825018) and the Key Clinical Program of the Ministry of Health of China (No. 2010439).
The efficacy and safety of recombinant tissue plasminogen activator (rtPA) need to be improved due to its low bioavailability and requirement of large dose administration. The purpose of this study was to develop a ...
关键词:recombinant tissue plasminogen activator THROMBOLYSIS NANOPARTICLES drug delivery system 
Simulation of fine polydisperse particle condensational growth under an octadecane-nitrogen atmosphere被引量:2
《Particuology》2018年第3期71-79,共9页Hua Zhang Ze Wang Wenli Song Songgeng Li 
This work was supported by the National Basic Research Pro- gram of China (973 Program, 2014CB744300), by the National Natural Science Foundation of China (51476180), and by Meso- science Innovation Fund (COM2015A004). Discussion with Dr. Susanne Hering on his experiment and effects of initial size is acknowledged.
The evolution of particle size distribution (PSD) of fine polydisperse particles at high number concen- trations (7105 cm-3) was simulated through a combined model employing direct quadrature method of moments (D...
关键词:SIMULATION Condensational growth Polydisperse particles Particle size distribution 
Antisense transcription regulates the expression of sense gene via alternative polyadenylation
《Protein & Cell》2018年第6期540-552,共13页Ting Shen Huan Li Yifan Song Jun Yao Miao Han Ming Yu Gang Wei Ting Ni 
We thank Drs. Li Jin, Feng Qian, Jun Zhu and Hongjie Yao for constructive suggestions of this manuscript. The vectors of CRISPR/ Cas9 are the generous gifts from Drs. Yangming Wang and Yong- ming Wang. This work was supported by the National Basic Research Program (973 Program) (Nos. 2013CB530700 and 2015CB943000 to T. N.) and National Natural Science Foundation of China (Grant Nos. 31471192 and 31521003 to T. N.).
Natural antisense transcripts (NAT) and alternative polyadenylation (APA) of messenger RNA (mRNA) are important contributors of transcriptome complexity, each playing a critical role in multiple biological proce...
关键词:natural antisense transcripts alternative polyadenyaltion 3'UTR RNASEH2C KAT5 
On the selection of solutions for mutation in differential evolution被引量:2
《Frontiers of Computer Science》2018年第2期297-315,共19页Yong WANG Zhi-Zhong LIU Jianbin LI Han-Xiong LI Jiahai WANG 
Acknowledgements The authors would like to thank the anonymous reviewers for their very constructive and helpful suggestions. This work was supported in part by the National Basic Research Program (973 Program) of China (2011CB013104), in part by the Innovation-driven Plan in Central South University (2015CXS012 and 2015CX007), in part by the National Natural Science Foundation of China (Grant Nos. 61273314 and 61673397), in part by the EU Horizon 2020 Marie Sldodowska-Curie Individual Fellowships (Project ID: 661327), in part by the Hunan Provincial Natural Science Fund for Distinguished Young Scholars (2016JJ1018), in part by the Program for New Century Excellent Talents in University (NCET-13-0596), and in part by State Key Laboratory of Intelligent Control and Decision of Complex Systems, Beijing Institute of Technology.
Differential evolution (DE) is a kind of evolutionary algorithms, which is suitable for solving complex optimization problems. Mutation is a crucial step in DE that generates new solutions from old ones. It was argu...
关键词:differential evolution MUTATION the selection of solutions for mutation evolutionary algorithms 
A hydrodynamic model of loop seal with a fluidized standpipe for a circulating fluidized bed被引量:1
《Particuology》2018年第1期50-58,共9页Changjin Li Zheng ZOU Hongzhong Li Qingshan Zhu 
The authors wish to gratefully acknowledge the financial sup- port from the State Key Development Program for Basic Research of China (973 Program) under Grant No. 2015CB251402 and from the National Natural Science Foundation of China under Grant Nos. 21325628 and 91334108.
Loop seals are among the most common non-mechanical valves used in circulating fluidized bed sys- tems. In the present work. a fundamental study is conducted of a fluidized loop seal, which consists of a fluidized sta...
关键词:Circulating fluidized bed Loop seal Hydrodynamic model 
Energy-coupling mechanism of the multidrug resistance transporter AcrB: Evidence for membrane potential-driving hypothesis through mutagenic analysis被引量:1
《Protein & Cell》2017年第8期623-627,共5页Liu, Min Zhang, Xuejun C. 
The authors thank Dr. Yong Tao of the Institute of Microbiology, CAS, for providing the ΔacrB cell strain. We thank Dr. Torsten Juelich for linguistic assistance during the preparation of this manuscript. This work was supported by the National Basic Research Program (973 Program) (No. 2015CB910104 to XCZ) and National Natural Science Foundation of China (Grant No. 31470745 to XCZ).
Dear Editor, RND (resistance nodulation-cell division) exporters are widely expressed across the lineage of Gram-negative bacteria (Fig. S1 ). Their functional role is to utilize the protonmotive force of the cell...
关键词:突变分析 耦合机制 ACRB 驱动 膜电位 转运体 证据 假说 
Recent progress and trends in predictive visual analytics被引量:1
《Frontiers of Computer Science》2017年第2期192-207,共16页Junhua LU Wei CHEN Yuxin MA Junming KE Zongzhuang LI Fan ZHANG Ross MACIEJEWSKI 
This work was supported by National Basic Re- search Program of China (973 Program) (2015CB352503), Major Pro- gram of the National Natural Science Foundation of China (61232012), the National Natural Science Foundation of China (Grant Nos. 61303141, 61422211, u1536118, u1536119), Zhejiang Provincial Natural Science Foundation of China (LR13F020001), the Fundamental Research Funds for the Central Universities, the Innovation Joint Research Center for Cyber- Physical-Society System, and the United State's National Science Founda- tion (1350573).
A wide variety of predictive analytics techniques have been developed in statistics, machine learning and data mining; however, many of these algorithms take a black-box approach in which data is input and future pred...
关键词:predictive visual analytics VISUALIZATION visual analytics data mining predictive analysis 
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