国家自然科学基金(30425007)

作品数:8被引量:68H指数:5
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相关作者:文富强徐丹应斌武陈亚娟呙恒娟更多>>
相关机构:四川大学华西医院成都市传染病医院贵阳医学院附属医院更多>>
相关期刊:《Acta Pharmacologica Sinica》《四川医学》《Chinese Medical Journal》更多>>
相关主题:CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASEAIRWAYSMUCUSMUCINOVERPRODUCTION更多>>
相关领域:医药卫生生物学更多>>
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汉、藏族肺结核患者血清差异蛋白质的质谱分析被引量:4
《第三军医大学学报》2010年第18期1986-1990,共5页刘琦 刘新宇 张仁卿 吴桂辉 岳冀 李晓萍 文富强 
国家自然科学基金(30425007)~~
目的用表面增强激光解析电离-飞行时间质谱(SELDI-TOF MS)技术比较汉、藏族肺结核患者之间及其与相应的非结核对照者之间的血清差异蛋白,以寻找各自的质谱诊断模型并比较两个民族肺结核的蛋白质差异。方法收集2008年6月至2009年3月四川...
关键词:光谱法 质量 基质辅助激光解吸电离 肺结核 蛋白质组学 蛋白质阵列分析 民族差异性 
Effects of single nucleotide polymorphisms 869 T/C and 915 G/C in the exon 1 locus of transforming growth factor-β1 gene on chronic obstructive pulmonary disease susceptibility in Chinese被引量:9
《Chinese Medical Journal》2010年第4期390-394,共5页LIU Dai-shun LI Xiao-ou YING Bin-wu CHEN Lei WANG Tao XU Dan WEN Fu-qiang 
This study was supported by the grants from the National Natural Science Foundation of China (No. 30425007 and No. 30370627).Acknowledgement: We are grateful to LIAO Ga for the haplotype analysis, to YUN Li-bing and ZHOU Bin for the DHPLC analysis, and to JIA Zheng for helpful discussions. We are deeply grateful to the patients and families for their cooperation.
Background The main risk factor for chronic obstructive pulmonary disease (COPD) is cigarette smoking. However, only 10%-20% of chronic heavy smokers develop systematic COPD. We hypothesized that the inheritance of ...
关键词:chronic obstructive pulmonary disease transforming growth factor-ill gene polymorphism 
Simvastatin attenuates lipopolysaccharide-induced airway mucus hypersecretion in rats被引量:12
《Chinese Medical Journal》2008年第17期1680-1687,共8页OU Xue-mei WANG Bai-ding WEN Fu-qiang FENG Yu-lin HUANG Xiang-yang XIAO Jun 
This study was supported by grants from National Natural Science Foundation of China to Dr. WEN Fu-qing (No. 30425007, 30370627, 30670921) and from China Medical Board of New York to Dr. WEN Fu-qiang (No. 0-722).
Background Mucus hypersecretion in the respiratory tract and goblet cell metaplasia in the airway epithelium contribute to the morbidity and mortality associated with airway inflammatory diseases. This study aimed to ...
关键词:mucus hypersecretion LIPOPOLYSACCHARIDE SIMVASTATIN RHOA mitogen-activated protein kinases p38 
Mucus hypersecretion in the airway被引量:8
《Chinese Medical Journal》2008年第7期649-652,共4页WANG Ke WEN Fu-qiang XU Dan 
This study was supported by the grants from National Natural Science Foundation of China and China Medical Board of New York to Dr. Wen (No. 30425007, 30370627, 00-722, 00-384).
Mucus hypersecretion is a distinguishing feature of chronic inflammation diseases, such as asthma,chronic bronchitis, bronchiectasis and cystic fibrosis Mucus hypersecretion leads to impairment of mucociliary clearanc...
关键词:mucus hypersecretion AIRWAY 
Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease被引量:25
《Acta Pharmacologica Sinica》2007年第8期1166-1174,共9页Ke WANG Yu-lin FENG Fu-qiang WEN Xue-rong CHEN Xue-mei OU Dan XU Jie YANG Zhi-ping DENG 
This study was supported by grants from the National Natural Science Foundation of China(No 30425007,30370627); from the China Medical Board of New York to Dr Fu-qiang WEN(No 00-722).
Aim: To investigate the relationship between aquaporin-5 (AQPs) expression and mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease (COPD) and the correlation with pu...
关键词:AQUAPORIN-5 mucin 5AC MUCIN mucus overproduction chronic obstructive pulmonary disease 
Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease被引量:8
《Chinese Medical Journal》2007年第12期1051-1057,共7页WANG Ke FENG Yu-ling WEN Fu-qiang CHEN Xue-rong OU Xue-mei XU Dan YANG Jie DENG Zhi-pin 
the grants from Natural Science Foundation of China and from China Medical Board of New York to Dr. F.Q. Wen(No.30425007,30370627,00-722,06-838)
Background Chronic obstructive pulmonary disease (COPD) is usually complicated with mucus overproduction in airway. Recently the increased expression of the human calcium-activated chloride channel 1 (CaCC1) was f...
关键词:calcium-activated chloride channel 1 mucin 5AC MUCIN mucus overproduction chronic obstructive pulmonary disease 
利用毛细管电泳技术分析云南回族人群7个STR基因座的遗传多态性被引量:3
《第三军医大学学报》2006年第21期2119-2122,共4页呙恒娟 文富强 应斌武 刘代顺 邱容 陈亚娟 徐丹 
国家自然科学基金杰出青年基金资助项目(30425007);国家自然科学基金资助项目(30370627);美国纽约CMB基金资助项目;中国博士后基金资助项目(2005038268)~~
目的对云南回族群体的D3S1358/THO1/D21S11/D18S51/D5S818/D13S317/D7S820等7个STR基因座的遗传多态性进行群体遗传学研究。方法利用荧光标记复合扩增及毛细管电泳自动荧光检测的方法,对204例无关个体的7个STR基因座进行检测。结果获得...
关键词:毛细管电泳 短串联重复序列(STR) 复合扩增 群体遗传学 
6个STR基因座在广东潮汕地区汉族人群多态性研究被引量:1
《四川医学》2006年第6期551-553,共3页邱容 文富强 应斌武 徐丹 呙恒娟 陈亚娟 
国家自然科学杰出青年基金(批准号30425007)资助;国家自然科学基金(批准号30370627)资助;美国纽约CMB基金;中国博士后基金资助
目的调查6个STR基因座在中国广东潮汕地区汉族人群中的基因频率分布。方法应用四色荧光标记引物复合扩增技术对251名广东潮汕地区汉族无关个体血样的6个STR基因座进行多态性研究。结果在广东潮汕地区汉族人群中6个STR基因座个体识别概率...
关键词:群体遗传学 汉族 STR 基因座 复合扩增 遗传多态性 
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