云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(51390484)

国家自然科学基金(51390484): 作品数：16被引量：48H指数：5; 导出分析报告; 相关作者：陈学思马丽莉杨晨光邵俊汤朝晖更多>>; 相关机构：中国科学院中国科学院大学江西师范大学更多>>; 相关期刊：《Regenerative Biomaterials》《Science China Chemistry》《Science China Materials》《Chinese Journal of Polymer Science》更多>>; 相关主题：DOXPOLYSYNERGISTICPOLYLACTIDEBIODEGRADABILITY更多>>; 相关领域：医药卫生理学化学工程农业科学更多>>

Macrophages loaded CpG and GNR-PEI for combination of tumor photothermal therapy and immunotherapy被引量：5: 《Science China Materials》2018年第11期1484-1494,共11页Jie Chen Lin Lin Nan Yan Yingying Hu Huapan Fang Zhaopei Guo Pingjie Sun Huayu Tian Xuesi Chen; financially supported by the National Natural Science Foundation of China (51390484, 21474104, 51403205, 51503200 and 51520105004);National program for support of Top-notch young professionals;Jilin province science and technology development program (20160204032GX, 20180414027GH); Nano-therapeutic approach for clinical implementation of tumors remains a longstanding challenge in the medical field. The main challenges are rapid clearance, offtarget effect and the limited role in the treatment of...; 关键词：hyperbranched polymers IMMUNOTHERAPY MACROPHAGES photothermal therapy synergistic treatment

DOX/IL-2/IFN-g co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment被引量：11: 《Bioactive Materials》2018年第1期118-128,共11页Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen; The financial support from the National Natural Science Foundation of China(No.51403202,51622307,51390484,51520105004)are gratefully thanked.; Melanoma has been a serious threat to the human health;however,effective therapeutic methods of this cancer are still limited.Combined local therapy is a crucial approach for achieving a superior anti-tumor efficacy.I...; 关键词：Polypeptide hydrogel Sustained co-delivery Combination therapy Local cancer treatment Thermosensitive hydrogel

糖聚肽高分子的合成、自组装及生物医学应用被引量：2: 《高分子学报》2018年第1期45-55,共11页肖春生丁建勋贺超良陈学思; 国家自然科学基金(基金号51773196,51573184,51390484,51520105004); 中国科学院青年创新促进会项目(项目号2017266)资助; 糖聚肽高分子是一类由聚肽(也称聚氨基酸)和糖类化合物(包括单糖、寡糖和多糖)构成的生物可降解高分子.糖聚肽高分子具有与天然糖蛋白分子类似的化学组成,能够在一定程度上模拟天然糖蛋白的结构和性能,近年来引起了学术界的广泛研究兴趣...; 关键词：糖聚肽聚氨基酸开环聚合自组装生物医学应用

Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment: 《Science China Materials》2017年第10期995-1007,共13页Guanyi Wang Wantong Song Na Shen Haiyang Yu Mingxiao Deng Zhaohui Tang Xueqi Fu Xuesi Chen; supported by the National Natural Science Foundation of China (51520105004,51673189,51390484,51403204,51673185,51473029 and 51503202);Science and Technology Service Network Initiative (KFJ-SW-STS-166);the Chinese Academy of Sciences Youth Innovation Promotion Association; Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metasta...; 关键词：CURCUMIN drug delivery PLGA METASTATIC osteo-sarcoma

Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery被引量：6: 《Chinese Journal of Polymer Science》2017年第6期693-693,694-699,共7页Xiang-ru Feng 丁建勋 Ruxandra Gref Xue-si Chen; financially supported by the National Natural Science Foundation of China(Nos.51673190,51303174,51603204 and 51390484); A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly（ethylene glycol）-block-poly（L-lactide/D-lactide）-cholesterol （4-armed PEG-b-PLLA/P...; 关键词：POLYLACTIDE Stereocomplex micelle Poly（β-cyclodextrin） Host-guest interaction Controlled drug delivery

Anti-tumor effects of combined doxorubicin and siRNA for pulmonary delivery被引量：1: 《Chinese Chemical Letters》2017年第4期807-812,共6页Cai-Na Xu Hua-Yu Tian Yan-Bing Wang Yang Du Jie Chen Lin Lin Zhao-Pei Guo Xue-Si Chen; the National Natural Science Foundationof China(Nos.51503200,21474104,5123300451520105004 and 51390484);Jilin Province Science and Technology Development Program(No.20160204032GX);the National Program for Support of Top-notch Young Professionals for financial support; Direct administration of drugs and genes to the lungs by pulmonary delivery offers a potential effective therapy for lung cancers.In this study,combined doxorubicin（DOX） and Bcl2 siRNA was employed for cancer therap...; 关键词：Pulmonary delivery Anti-tumor effects Metastatic lung cancer Combined DOX and siRNA therapy Synergistic anti-tumor

Recent progress in cationic polymeric gene carriers for cancer therapy被引量：2: 《Science China Chemistry》2017年第3期319-328,共10页Caina Xu Huayu Tian Xuesi Chen; supported by the National Natural Science Foundation of China(51503200,21474104,51233004,51520105004, 51390484);Jilin Province Science and Technology Development Program (20160204032GX);the National Program for Support of Top-notch Young Professionals; In recent years,various carriers for gene delivery nave been developed for biomedical applications.Among all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have ...; 关键词：polymeric gene carriers cancer therapy stimuli-responsive carriers multifunctional gene carriers

Polyglutamic Acid Based Polyanionic Shielding System for Polycationic Gene Carriers被引量：2: 《Chinese Journal of Polymer Science》2016年第3期316-323,共8页Jia-liang Xia 田华雨 Jie Chen Zhao-pei Guo Lin Lin Hong-yan Yang Zong-cai Feng; financially supported by the National Natural Science Foundation of China(Nos.51203132,51222307,51303173,51390484,21474104 and 51403205);Natural Science Foundation of Guangdong Province,China(S2012040008070);Foundation for Distinguished Young Talents in Higher Education of Guangdong,China(2012LYM_0093); For the purpose of increasing the in vivo stability of polycation gene carriers, we prepared a kind of p H-sensitive poly（ethylene glycol）-poly（γ-benzyl-L-glutamate-co-glutamic acid）（PEG-PGA（65）, 65 denotes th...; 关键词：Gene delivery Shielding system PEGylation pH Sensitive

PDLA-PBS-PDLA三嵌段共聚物的合成及性能被引量：7: 《高等学校化学学报》2015年第11期2329-2334,共6页马丽莉邵俊杨晨光汤朝晖陈学思; 国家自然科学基金(批准号:51273198,51373169,51233004,51303176,51390484,51321062,51403089);国家“八六三”计划项目(批准号:2011AA02A202)资助~~; 合成了末端均为羟基的聚丁二酸丁二醇酯（PBS）预聚物，再以PBS的端羟基引发D-丙交酯（D—LA）开环聚合，得到聚右旋乳酸（PDLA）与PBS的三嵌段共聚物（PDLA—PBS—PDLA）．通过凝胶渗透色谱和核磁共振氢谱进行了结构表征．随着m（D—L...; 关键词：聚丁二酸丁二醇酯右旋聚乳酸 PDLA—PBS—PDLA三嵌段共聚物

Schiff base aluminum catalysts containing morpholinomethyl groups in the ring opening polymerization of rac-lactide: 《Science China Chemistry》2015年第11期1741-1747,共7页Zhijie Guo Ranlong Duan Mingxiao Deng Xuan Pang Chenyang Hu Xuesi Chen; supported by the National Natural Science Foundation of China(51173183,51233004,51390484,51321062,51473029); A series of Schiff base aluminum(III) complexes bearing morpholinomethyl substituents were synthesized. Comprehensive investigations on their stereoselective and kinetic features in the ring opening polymerization of ...; 关键词：POLYLACTIDE morpholinomethyl ring opening polymerization

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