国家教育部博士点基金(20050285017)

作品数：4被引量：8H指数：2
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相关作者：林芳秦正红何晓辉更多>>
相关机构：苏州大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Neuroscience Bulletin》《Acta Biochimica et Biophysica Sinica》更多>>
相关主题：HUNTINGTINENDOPLASMIC_RETICULUMPROTEIN_FOLDINGDISEASECALNEXIN更多>>
相关领域：医药卫生生物学更多>>
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Current understanding on the pathogenesis of polyglutamine diseases被引量：2
《Neuroscience Bulletin》2010年第3期247-256,共10页何晓辉 林芳 秦正红 
supported by the grants from the National Natural Science Foundation of China(No.30600197);the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20050285017)
Polyglutamine （polyQ） diseases are a family of neurodegenerative disorders including Huntington’s disease, spinobulbar muscular atrophy,dentatorubral-pallidoluysian atrophy and several spinocerebellar ataxias.polyQ...
关键词：POLYGLUTAMINE the central nervous system neurodegenerative diseases late-onset disorders UBIQUITIN autophagy 
Huntingtin Cleavage Induced by Thrombin In Vitro
《Acta Biochimica et Biophysica Sinica》2007年第1期15-18,共4页Fang LIN Junchao WU Yan WANG and Zhenghong QIN Department of Pharmacology,Laboratory of Aging and Nervous Diseases,Soochow University School of Medicine,Suzhou 215123,China 
This work was supported by grants from the National Natural Science Foundation of Chilla(No. 30370506);the China Postdoctoral Science Foundation;the Specialized Research Fund for the Doctoral Program of Higher Education(No.20050285017)
Huntingtin （Htt） mutation causes Huntington＇s disease. Sequence analysis of Htt revealed a possible thrombin cleavage site in the N-terminal region of Htt. In order to investigate if thrombin can cleave Htt, we exp...
关键词：THROMBIN huntingtin （Htt） CLEAVAGE HIRUDIN 
Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies被引量：2
《Acta Pharmacologica Sinica》2006年第10期1287-1302,共16页Lin-hui WANG Zheng-hong QIN 
Project supported by the National Natural Science Foundation of China(No 30370506);by the Specialized Research Fund for the Doctoral Program of Higher Education(No 20050285017).
Huntington＇s disease （HD） is an autosomal dominant neurodegenerative disorder, which is caused by an abnormal expansion of Cytosine Adenine Guanine （CAG） trinucleotide repeat in the gene making huntingtin （Htt）...
关键词：Huntington＇s disease HUNTINGTIN NEURODEGENERATION animal models 
Quality Control System of the Endoplasmic Reticulum and Related Diseases被引量：4
《Acta Biochimica et Biophysica Sinica》2006年第4期219-226,共8页Jun-Chao WU Zhong-Qin LIANG Zheng-Hong QIN 
This work was supported by the grants from the National Natural Science Foundation of China (No.30370506);the Doctoral Program of Higher Education of China (No.20050285017)
The quality control （QC） system of the endoplasmic reticulum （ER） is an important monitoring mechanism in the protein maturation process, which ensures export of properly folded proteins from the ER. Incorrectly o...
关键词：protein folding quality control calnexin/calreticulin cycle endoplasmic reticulum-associated degradation protein misfolding disease 
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