国家重点基础研究发展计划(2012CBA01305)

作品数：7被引量：19H指数：3
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相关作者：王青松尹海芳更多>>
相关机构：天津医科大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《天津医科大学学报》《Science Bulletin》更多>>
相关主题：TAILEDMACAQUEMACAQUESMACACAHIV-1更多>>
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Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition
《Science China(Life Sciences)》2018年第8期954-965,共12页Dan Mu Jia-Wu Zhu Feng-Liang Liu Hong-Yi Zheng Yong-Tang Zheng 
supported by grants from the National Natural Science Foundation of China (81471620, 81671627, 81571606, 81172876, U0832601);the 13th Five-Year Key Scientific and Technological Program of China (2017ZX10304402-002-004, 2017ZX10202102-001-005);the Knowledge Innovation Program of the Chinese Academy of Sciences (KJZD-EW-L1002, KSCX2-EW-R-13);the National Key Research & Development Plan (2016YFC1201000);the National Basic Research Program of China (2012CBA01305)
TRIM5α restricts retroviruses in a species-specific manner. Cyclophilin A was independently retrotransposed into the TRIM5 loci in different species, leading to the generation of antiviral TR1M5-cyclophilin A （TRIM...
关键词：TRIMCyp/TRIM5α assam macaque HIV-1 N-MLV functional trade-off 
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina)infected with SIVmac239被引量：2
《Zoological Research》2018年第1期42-51,共10页tian-zhang song ming-xu zhang yu-jie xia yu xiao wei pang yong-tang zheng 
partly supported by grants from the National Natural Science Foundation of China(81471620;81671627;81571606;81601808;81172876;U0832601);the National Basic Research Program of China(2012CBA01305);the 13th Five-Year Key Scientific and Technological Program of China(2017ZX10304402-002-004;2017ZX10202102-001-005);the National Key Research & Development(R&D)Plan(2016YFC1201000)
Parasites can increase infection rates and pathogenicity in immunocompromised human immunodeficiency virus （HIV） patients. However, in vitro studies and epidemiological investigations also suggest that parasites mig...
关键词：AIDS IMMUNOCOMPROMISED Northernpig-tailed macaque Parasite SIVMAC239 
HIV-1 can infect northern pig-tailed macaques(Macaca leonina) and form viral reservoirs in vivo被引量：3
《Science Bulletin》2017年第19期1315-1324,共10页Wei Pang Gao-Hong Zhang Jin Jiang Hong-Yi Zheng Lin-Tao Zhang Xiao-Liang Zhang Jia-Hao Song Ming-Xu Zhang Jia-Wu Zhu Ai-Hua Lei Ren-Rong Tian Xiao-Ming Liu Liguo Zhang Guangxia Gao Lishan Su Yong-Tang Zheng 
supported by the National Basic Research Program of China (2012CBA01305);the National Natural Science Foundation of China (81172876; 81571606; 81471620; U0832601; 30671960);the 13th Five-Year Key Scientific and Technological Program of China (2017ZX10304402002-004; 2017ZX10202102-001-005);the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-R-13; KJZD-EW-L10-02; CASIMM0320163020);the National Key Research & Development Plan (2016YFC1201000);Yunnan Applicative and Basic Research Program (2014FB181; 201501PH00015)
Viral reservoirs of HIV-1 are a major obstacle for curing AIDS. The novel animal models that can be directly infected with HIV-I will contribute to develop effective strategies for eradicating infections. Here, we ino...
关键词：Northern pig-tailed macaquesHIV-1 Viral reservoir JQ1 Prostratin 
Longitudinal analysis reveals characteristically high proportions of bacterial vaginosis-associated bacteria and temporal variability of vaginal microbiota in northern pig-tailed macaques （Macaca leonina）被引量：5
《Zoological Research》2015年第5期285-298,共14页Lin ZHU Ai-Hua LEI Hong-Yi ZHENG Long-Bao LYU Zhi-Gang ZHANG Yong-Tang ZHENG 
supported in part by the Key Scientific and Technological Program of China(2012ZX10001-007;2013ZX10001-002);the National Basic Research Program of China(2012CBA01305);the National Natural Science Foundation of China(81172876;81273251;U1202228);the Knowledge Innovation Program of CAS(KSCX2-EW-R-13;KJZD-EW-L10-02)
The complex and dynamic vaginal microbial ecosystem is critical to both health and disease of the host. Studies focusing on how vaginal microbiota influences HIV-1 infection may face limitations in selecting proper an...
关键词：MACAQUE Vaginal microbiome Bacterialvaginosis Temporal dynamics Networks 
诱导型狨猴肝纤维化模型的建立
《天津医科大学学报》2014年第6期433-436,共4页李萌乾 王青松 郭正隆 尹海芳 
国家973重大科学研究计划资助项目(2012CBA01305)
目的:建立诱导型狨猴肝纤维化模型。方法:手术切除普通狨猴部分肝脏,通过腹腔注射二乙基亚硝胺(DENA-2.5 mg/kg),并利用体质量和肝功能检测、病理分析、免疫组化,胶原染色和B超小动物活体成像等手段进行监测。结果:手术切除肝脏促使狨...
关键词：肝纤维化 普通狨猴 二乙基亚硝胺 肝切除 
Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque （Macaca leonina）被引量：5
《Zoological Research》2014年第3期186-195,共10页Ai-Hua LEI Gao-Hong ZHANG Ren-Rong TIAN Jia-Wu ZHU Hong-Yi ZHENG Wei PANG Yong-Tang ZHENG 
Foundation items： This work was supported by the National Basic Research Program （2012CBA01305）; the National Natural Science Foundation of China （81172876, U0832601, 81273251 and U 1202228） the Knowledge Innovation Program of CAS （KSCX2-EW-R-13, Y206A- 71181）, and the Key Scientific and Technological Program of China （2012ZX10001-007, 2013ZX10001-002）. Acknowledgements： We thank Prof. Guang-Xia GAO （Institute of Biophysics, Chinese Academy of Sciences） for kindly providing HSIV proviral plasmids.We also thank Long-Bao LV, Gui LI and Dong- Ti HUANG of Kunming Primate Research Center for their assistance in obtaining blood samples from northem pig-tailed macaques （M. leonina） and Chinese rhesus macaques.
The northern pig-tailed macaque （Macaca leonina） has been identified as an independent species of Old World monkey, and we previously found that PBMCs from M. leonina were susceptible to human immunodeficiency virus...
关键词：HIV-1 HSIV REPLICATION PBMC Northern pig-tailed macaque （Macaca leonina） 
Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques被引量：7
《Cellular & Molecular Immunology》2012年第5期410-416,共7页Jian-Ping Ma Hou-Jun Xia Gao-Hong Zhang Jian-Bao Han Li-Guo Zhang Yong-Tang Zheng 
ACKNOWLEDGEMENTS This work was supported in part by grants from the National Basic Research Program of China （2009CB522306 and 2012CBA01305）, the National Natural Science Foundation of China （30872317, 30800113, U0832601 and 81172876）, the Knowledge Innovation Program of CAS （KSCX1-YW-10 and KSCX2-EW-R-13）, the Key Scientific and Technological Program of China （2009ZX09501-029, 2012ZX10001-006 and 2012ZX10001-007） and Yunnan province （2010GA001） and the ＇Western Light＇ Projects of the CAS. The funding organizations had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
It is currently widely accepted that immune activation in HIV-infected individuals leads to a severe loss of CD4＋ T cells and the progression to AIDS. However, the underlying mechanism of this immune activation remai...
关键词：Chinese rhesus macaque CHLOROQUINE immune activation pDC SIV 
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