Grant sponsor:National Nature Science Foundation of China,Grant number:81272960;Key Research Program from Science and Technology Department of Hunan Province China,Grant number:2013WK2010 and 2014SK2015;The fund of Tianqing liver disease research;This work was supported by National Nature Science Foundation of China(81272960);Key Research Program from Science and Technology Department of Hunan Province,China(2013WK2010 and 2014SK2015);Key Research Program from Ministry of human Resources and Social Security of the People’s Republic of China(2016)176.
Hypoxia-inducible factor(HIF)is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes.HIF is frequen...