国家自然科学基金(s20872028)

作品数：6被引量：19H指数：3
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相关作者：黄文龙胡国强更多>>
相关机构：中国药科大学河南大学更多>>
相关期刊：《应用化学》《Chemical Research in Chinese Universities》《Chinese Chemical Letters》《Acta Pharmaceutica Sinica B》更多>>
相关主题：FLUOROQUINOLONEANTITUMORSYNTHESISEVALUATIONC3更多>>
相关领域：理学生物学农业科学更多>>
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饶丹宁甲叉基取代左氧氟沙星衍生物的合成与抗肿瘤活性被引量：1
《应用化学》2021年第2期188-194,共7页张会丽 崔红艳 黄文龙 胡国强 
国家自然科学基金(Nos.20872028,21072045)项目资助。
为寻找提高氟喹诺酮肿瘤活的有效结构修饰策略,左氧氟沙星(3)的衍生物(S)-(-)-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-[1,4]噁嗪并[2,3,4-ij]-喹啉-7(4 H)-酮-6-甲醛(5)与饶丹宁类(2a-2l)通过Claisen-Schmid缩合反应构建了饶丹宁...
关键词：氟喹诺酮 饶丹宁 不饱和酮 生物电子等排体 抗肿瘤活性 
Synthesis and antibacterial activity of novel[1,2,4]triazolo[3,4-h][1,8]naphthyridine-7-carboxylic acid derivatives被引量：3
《Chinese Chemical Letters》2015年第1期149-151,共3页Liu-Zhou Gao Yu-Suo Xie Tao Li Wen-Long Huang Guo-Qiang Hu 
support provided by the National Natural Science Foundation of China(Nos.20872028 and 21072045)
Novel tricyclic fluoroquinolones,[1,2,4]triazolo[3,4-h][1,8]naphthyridine-8-one-7-carboxylic acid derivatives 4a-4h bearing carrying a functional Mannich-base moiety at the C-8 position,were synthesized and evaluated ...
关键词：TRIAZOLE Tricyclic fluoroquinolone SYNTHESIS Antibacterial activity 
Design,Synthesis and Antitumor Activity of Fluoroquinolone C3 Heterocyclic Bis-oxadiazole Methylsulfide Derivatives Derived from Levofloxacin被引量：3
《Chemical Research in Chinese Universities》2012年第6期980-984,共5页HU Guo-qlang WANG Guo-qiang DUAN Nan-nan WEN Xiao-yi CAO Tie-yao XIE Song-qiang HUANG Wen-long 
Supported by the National Natural Science Foundation of China(Nos.20872028,21072045)
To discover an efficient route for the shift from an antibacterial fluoroquinolone to an antitumor one based on the mechanistic similarities between targeting topoisomerases and the eukaryotic ones,two series of the t...
关键词：FLUOROQUINOLONE OXADIAZOLE ISOSTERE SULFIDE Piperazinium Antitumor activity 
Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives(Ⅲ):Mono- and bis-Schiff-bases被引量：9
《Chinese Chemical Letters》2012年第5期515-517,共3页Guo Qiang Hu Xiao Kui Wu Guo Qiang Wang Nan Nan Duan Xiao Yi Wen Tie Yao Cao Yin Jun Wang Wei Song Qiang Xie Wen Long Huang 
supported by the National Natural Science Foundation of China(Nos20872028 and 21072045)
To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h c...
关键词：FLUOROQUINOLONE Schiff base Antitumor evaluation 
Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles(Ⅱ):From triazolothiadiazines to pyrazolotriazoles被引量：1
《Chinese Chemical Letters》2011年第7期804-806,共3页Guo Qiang Hu Li Li Hou Yong Yang Lei Yi Song Qiang Xie Guo Qiang Wang Nan Nan Duan Tie Yao Chao Xiao Yi Wen Wen Long Huang 
supported by National Natural Science Foundation of China(Nos.20872028,21072045)
To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fu...
关键词：FLUOROQUINOLONE Triazolothiadiazine Pyrazolotriazole Antitumor evaluation 
Design, synthesis and antitumor activity of C3/C3 bis-fluoroquonolones cross-linked with [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole被引量：2
《Acta Pharmaceutica Sinica B》2011年第3期172-177,共6页Guo-qiang Hu Yong Yang Lei Yi Guo-qiang Wang Nan-nan Duan Xiao-yi Wen Tie-yao Cao Song-qiang Xie Wen-Long Huang 
supported by the National Natural Science Foundation of China(nos.20872028,21072045).
To contribute to the development of an efficient method for the conversion of antibacterial fluoroquinolones to antitumor fluoroquinolones,a series of C3/C3 bis-fluoroquinolone fused heterocycles cross-linked with a[1...
关键词：FLUOROQUINOLONE Triazolothiadiazole SYNTHESIS Antitumor evaluation 
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