ISOSTERE

作品数：3被引量：3H指数：1
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相关领域：理学更多>>
相关作者：杨晓鸣邹晓民徐萍吕杨杜冠华更多>>
相关机构：北京大学中国医学科学院北京协和医学院更多>>
相关期刊：《Chemical Research in Chinese Universities》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金更多>>
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Design,Synthesis and Antitumor Activity of Fluoroquinolone C3 Heterocyclic Bis-oxadiazole Methylsulfide Derivatives Derived from Levofloxacin被引量：3
《Chemical Research in Chinese Universities》2012年第6期980-984,共5页HU Guo-qlang WANG Guo-qiang DUAN Nan-nan WEN Xiao-yi CAO Tie-yao XIE Song-qiang HUANG Wen-long 
Supported by the National Natural Science Foundation of China(Nos.20872028,21072045)
To discover an efficient route for the shift from an antibacterial fluoroquinolone to an antitumor one based on the mechanistic similarities between targeting topoisomerases and the eukaryotic ones,two series of the t...
关键词：FLUOROQUINOLONE OXADIAZOLE ISOSTERE SULFIDE Piperazinium Antitumor activity 
Synthesis and activity of hydroxyethylene peptidomimetic inhibitors of humanβ-secretase
《Journal of Chinese Pharmaceutical Sciences》2008年第3期215-220,共6页马超 王月华 杨晓鸣 邹晓民 吕杨 杜冠华 徐萍 
National Natural Science Foundation of China(Grant No.30772650 and 20772008).
A series of β-secretase peptidomimetic inhibitors with Leu＊Ala hydroxyethylene dipeptide isostere were synthesized and their β-secretase inhibitory activities were measured. The most potent compound N9 showed an in...
关键词：β-Secretase inhibitors Hydroxyethylene isostere SYNTHESIS Bioactivity 
Synthesis of Hydroxyethylene-based β-Secretase Inhibitors
《Journal of Chinese Pharmaceutical Sciences》2006年第2期101-108,共8页杨晓鸣 邹晓民 傅翌秋 牟科 徐萍 
National Natural Science Foundation of China(20272004 and 20572006);985 Program, Min-istry of Education of China.
Aim To discuss in depth the synthesis of hydroxyethylene dipeptide-based β-secretase inhibitors; Methods Organic reactions such as nucleophilic addition and substitution assisted by organometallic agents, catalytic h...
关键词：Β-SECRETASE PEPTIDOMIMETICS hydroxyethylene dipeptide isostere SYNTHESIS 
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