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国家自然科学基金(30870810): 作品数：16被引量：36H指数：5; 导出分析报告; 相关作者：王大勇武秋立沈露露林兴凤杨燚超更多>>; 相关机构：东南大学更多>>; 相关期刊：《Neuroscience Bulletin》《Journal of Environmental Sciences》《东南大学学报（医学版）》更多>>; 相关主题：CAENORHABDITIS_ELEGANS英文秀丽线虫NEMATODELIFESPAN更多>>; 相关领域：医药卫生生物学农业科学轻工技术与工程更多>>

Inhibition of ROS elevation and damage to mitochondrial function prevents lead-induced neurotoxic effects on structures and functions of AFD neurons in Caenorhabditis elegans被引量：3: 《Journal of Environmental Sciences》2012年第4期733-742,共10页Qiuli Wu Peidang Liu Yinxia Li Min Du Xiaojuan Xing Dayong Wang; supported by the National Basic Research Program (973) of China (No. 2011CB933404);and the National Natural Science Foundation of China (No.30870810,81172698);Some strains used were provided by Caenorhabditis Genetics Center (funded by the NIH National Center for Research Resource,USA); Here we investigated the possible roles of oxidative stress in the formation of decreased thermotaxis to cultivation temperature in lead （Pb）-exposed nematodes Caenorhabditis elagans. Exposure to Pb at the examined ...; 关键词：THERMOTAXIS lead exposure oxidative stress AFD sensory neuron Caenorhabditis elegans

Modulation of the assay system for the sensory integration of 2 sensory stimuli that inhibit each other in nematode Caenorhabditis elegans被引量：1: 《Neuroscience Bulletin》2011年第2期69-82,共14页李隐侠汪洋胡亚欧仲纪祥王大勇; supported by the National Natural Science Foundation of China (No. 30870810);National Basic Research Program of China (No. 2011CB933404); Objective To perform the modulation of an assay system for the sensory integration of 2 sensory stimuli that inhibit each other.Methods The assay system for assessing the integrative response to 2 reciprocally-inhibit...; 关键词：sensory integration paired stimuli assay system metal ion barrier C.elegans

Confirmation of combinational effects of calcium with other metals in a paper recycling mill effluent on nematode lifespan with toxicity identification evaluation method被引量：6: 《Journal of Environmental Sciences》2010年第5期731-737,共7页Dayong Wang,Yang Wang,Lulu Shen Key Laboratory of Developmental Genes and Human Disease in Ministry of Education,Department of Genetics and Developmental Biology,Southeast University Medical School,Nanjing 210009,China.; supported by the National Natural Science Foundation of China (No. 30771113,30870810);the Program for New Century Excellent Talents in University;provided by the Caenorhabditis Genetics Center (Funded by the NIH,National Center for Foundation from Research Resource,USA); We used toxicity identification evaluation （TIE） method to confirm the combinational effects of identified toxic metals in a paper recycling mill effluent in inducing the decreased lifespan in nematode Caenorhabditi...; 关键词：LIFESPAN CALCIUM combinational toxicity toxicity identification evaluation （TIE） Caenorhabditis elegans

重金属暴露秀丽线虫中存在咽泵运动与寿命之间的显著关联(英文)被引量：8: 《东南大学学报（医学版）》2010年第1期10-16,共7页杨燚超邢晓娟王大勇; supported by the grants from the National Natural Science Foundation of China(No.30870810);the Program for New Century Excellent Talents in University; 目的:分析重金属暴露秀丽线虫中咽泵运动与寿命之间的相关性。方法:毒性评估实验选择重金属Hg、Pb、Cr与Cd。分析重金属暴露秀丽线虫中咽泵运动的变化情况,并进一步利用线性回归方法分析重金属暴露秀丽线虫中咽泵运动与寿命之间的相关...; 关键词：重金属关联咽泵运动寿命秀丽线虫

重金属暴露可以改变秀丽线虫的脂肪积累(英文)被引量：2: 《东南大学学报（医学版）》2010年第1期17-23,共7页武秋立杜敏王大勇; supported by the grants from the National Natural Science Foundation of China(No.30870810);the Program for New Century Excellent Talents in University; 目的:研究重金属暴露对秀丽线虫脂肪积累的急性中毒效应,鉴定重金属暴露秀丽线虫中发生表达模式改变的与脂肪酸代谢相关的基因。方法:银、镉、铬、铜、汞、锰和锌作为测试重金属,Nile Red荧光探针染色分析重金属暴露线虫肠道的脂肪酸含...; 关键词：脂肪积累金属暴露代谢途径 NILE Red染色秀丽线虫

利用排泄行为参数评价重金属暴露对于秀丽线虫代谢状态的毒害(英文)被引量：1: 《东南大学学报（医学版）》2010年第1期23-29,共7页武秋立杨燚超王大勇; supported by the grants from the National Natural Science Foundation of China(No.30870810);the Program for New Century Excellent Talents in University; 目的:研究重金属暴露对秀丽线虫排泄行为的影响。方法:用于分析的CdCl2、CrCl2、HgCl2和Pb(NO3)2溶液浓度分别为50、100、150和200μmol.L-1。参数平均排泄循环长度用于评价重金属暴露秀丽线虫的代谢状态改变。线性回归用于分析平均排...; 关键词：重金属排泄行为代谢状态秀丽线虫

百草枯处理通过诱导氧化胁迫导致严重涡虫致死率的发生(英文): 《东南大学学报（医学版）》2010年第1期30-36,共7页刘培党林兴凤王大勇; supported by the grants from the National Natural Science Foundation of China(No.30870810);the Program for New Cen-tury Excellent Talents in University; 目的:研究百草枯诱导的氧化胁迫在涡虫严重致死率发生中的角色。方法:动物的存活率用于反映涡虫的致死率。百草枯用来诱导严重的氧化胁迫,氧化胁迫的发生程度通过过氧化物酶(SOD)的活性变化来监测。游离氧自由基清除剂DMSO用来在百草枯...; 关键词：百草枯氧化胁迫致死率 DMSO 涡虫

热激胁迫可能通过降低脂肪与糖原的积累抑制涡虫的发育(英文): 《东南大学学报（医学版）》2010年第1期36-41,共6页刘培党林兴凤王大勇; supported by the grants from the National Natural Science Foundation of China(No.30870810);the Program for New Cen-tury Excellent Talents in University; 目的:探讨热激胁迫对于涡虫发育以及脂肪和糖原积累的影响。方法:涡虫的发育通过体长与体质量来评价。分析35℃热激胁迫处理涡虫的体长与体质量变化以及实质细胞中脂肪与糖原积累情况,并评价热激胁迫处理涡虫中发育与脂肪或糖原积累之...; 关键词：热激胁迫脂肪糖原发育涡虫

Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion: 《Neuroscience Bulletin》2010年第2期91-103,共13页沈露露杜敏林兴凤蔡婷王大勇; supported by the National Natural Science Foundation of China (No. 30771113,30870810);the Program for New Century Excellent Talents in University; Objective To investigate the interaction between the genes required for the functions of AWA olfactory neuron and insulin/IGF signaling in regulating the longevity of nematode Caenorhabditis elegans （C. elegans）. Me...; 关键词：LONGEVITY ODR-7 AWA olfactory neuron insulin/IGF signaling genetic interaction C. elegans

UNC-64 and RIC-4,the plasma membrane-associated SNAREs syntaxin and SNAP-25,regulate fat storage in nematode Caenorhabditis elegans: 《Neuroscience Bulletin》2010年第2期104-116,共13页武秋立芮琪贺可文沈露露王大勇; supported by the grants from the National Natural Science Foundation of China(No. 30771113, 30870810);the Program for New Century Excellent Talents in University; Objective To investigate whether genes required for synaptogenesis and synaptic function are also involved in fat storage control in Caenorhabditis elegans. Methods Fat storage was examined in mutants of genes affecti...; 关键词：fat storage synaptic function UNC-64 RIC-4 Caenorhabditis elegans

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