云南高校图书馆联盟文献共享服务平台- 国家重点基础研究发展计划(2013CB932800)

国家重点基础研究发展计划(2013CB932800): 作品数：11被引量：8H指数：2; 导出分析报告; 相关作者：刘文静李宾张萍李琳吕军鸿更多>>; 相关机构：中国科学院大学中国科学院上海应用物理研究所宁波大学中国科学院更多>>; 相关期刊：《Science China Chemistry》《Chemical Research in Chinese Universities》《Chinese Physics B》《核技术》更多>>; 相关主题：DNAAMCPEPTIDELIGATIONUBIQUITIN更多>>; 相关领域：理学医药卫生核科学技术生物学更多>>

原子力显微镜单分子力谱技术在G四链体研究中的应用被引量：2: 《南方医科大学学报》2018年第9期1107-1114,共8页刘文静孙彤张萍李琳吕军鸿李宾; 科技部973项目(2013CB932800);国家自然科学基金(31670871;11474173;11375253);中国科学院知识创新项目(QYZDJSSW-SLH019)~~; 端粒在细胞的生理病理过程中起到至关重要的作用。端粒末端有一段富含鸟嘌呤(G)的单链DNA重复序列,该序列在单价金属离子如Na+或K+作用下可以折叠形成G-四链体结构,这一结构不能被端粒酶延长,从而抑制了端粒酶的活性,因此成为了潜在的...; 关键词：G-四链体端粒单分子力谱原子力显微镜

Chemical synthesis of histone H2A with methylation at Gln104: 《Science China Chemistry》2017年第5期621-627,共7页Qiaoqiao He Jiabin Li Yunkun Qi Zhipeng Wang Yong Huang Lei Liu; supported by the National Basic Research Program of China(2013CB932800);the National Natural Science Foundation of China(21532004,21225207,81621002); Histone H2A methylation at Glnl04 （H2AQ104Me） is a new type of histone post-translational modification （PTM） discovered recently. This modification has been found to have significant influence on gene transcriptio...; 关键词：protein chemical synthesis glutamine methylation histone H2A thermal stability

基于原子力显微术的DNA折纸弹性模量的研究被引量：1: 《核技术》2017年第4期36-42,共7页虞国凯魏余辉刘林张萍王硕刘文静周星飞李宾; 科技部973项目(No.2013CB932800、No.2012CB932600);国家自然科学基金(No.11375253、No.11474173、No.31670871);中国科学院知识创新项目(No.QYZDJ-SSW-SLH019)资助~~; 原子力显微术(Atomic force microscopy,AFM)的力学成像模式可在高分辨成像的同时,定量测量材料的力学性质。然而,对尺度小、质地薄而软的生物分子的弹性模量的测量仍然是一个挑战。本文以脱氧核糖核酸(Deoxyribonucleic acid,DNA)折纸...; 关键词：原子力显微术 DNA折纸杨氏模量峰值力

Selective detection of mercury(II) and methylmercury(II) via coordinationinduced emission of a small-molecule probe被引量：1: 《Science China Chemistry》2016年第12期1651-1657,共7页Yan Yang Zhiyi Yao Wei Li Kui Chen Lei Liu Hai-Chen Wu; funded by the National Basic Research Program of China(2013CB932800);the National Natural Science Foundation of China(21375130,31571010,21204089 and 21475132); Mercury is one of the major toxic pollutants and has many adverse effects on human health. The main mercury species in the environment or in living organisms are inorganic mercuric ion （Hg2＋） and organic methylmerc...; 关键词：MERCURY METHYLMERCURY coordination-induced emission fluorescence enhancement SELECTIVITY

The effect of secondary structures on the generation of characteristic events during the translocation of DNA hybrid through ?-hemolysin: 《Science China Chemistry》2016年第1期135-141,共7页Xingyong Wang Yuru Li Ting Li Lei Liu Hai-Chen Wu; the National Basic Research Program of China (2013CB932800);the National Natural Science Foundation of China (21175135, 21375130, 21205119, 21475132);the CAS Hundred Talents Program; Nanopore has been developed to be a powerful,single-molecule analytical tool for sensing ions,small organic molecules and biomacromolecules such as proteins and DNAs.Generally,the identity of the analyte can be reveal...; 关键词：nanopore sensing DNA hybrid translocation signature event urea

Concentric Circular Approach in Mesoporous Silica Transition Process from Hexagonal to Vesicular Structure: 《Chemical Research in Chinese Universities》2015年第6期904-908,共5页HUANG Jue XIE Shihang MU Mingwei PENG Ce CAO Mengjing YAO Youwei CAI Qiang; We studied the synthesis of mesoporous silica from cetyltrimethyl ammonium bromide（CTAB） and so- dium dodecyl sulfate（SDS） at different molar ratios（R）. X-ray diffraction（XRD）, scanning electron spectroscopy ...; 关键词：Mesoporous material Cationic-anionic surfactant Structural transition SILICA SELF-ASSEMBLY

Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif被引量：1: 《Chinese Physics B》2014年第6期621-628,共8页徐悦陈虎璩玉杰 Artem K.Efremov 黎明欧阳钟灿刘冬生严洁; supported by Grants from the National Research Foundation through the Mechanobiology Institute Singapore and the Ministry of Education of Singapore(Grant No.MOE2012-T3-1-001)[to Yan J];the National Basic Research Program of China(Grant No.2013CB932800);the Major Research Plan of the National Natural Science Foundation of China(Grant Nos.91027046 and 91027045);the Fundamental Research Funds for the Central Universities(Grant No.2013121005); The DNA i-motif is a quadruplex structure formed in tandem cytosine-rich sequences in slightly acidic conditions. Besides being considered as a building block of DNA nano-devices, it may also play potential roles in r...; 关键词：single-molecule techniques I-MOTIF folding/structure of biomolecules mechanical proper-ties/biomolecules

Protein-assisted conjugated polymer microarray: Fabrication and sensing applications: 《Chinese Science Bulletin》2013年第33期4039-4044,共6页Lü FengTing FENG XuLi LIU LiBing WANG Shu; supported by the National Natural Science Foundation of China(21203213,21021091);the National Basic Research Program of China(2011CB808400,2013CB932800); A new strategy is performed to fabricate conjugated polymer microarray with the assistance of protein in this work.The water-soluble cationic conjugated polymer employed in the present work is capable of absorbing lig...; 关键词：共轭聚合物微阵列蛋白质传感制备应用聚合物芯片荧光信号

Chemical synthesis of Ub-AMC via ligation of peptide hydrazides被引量：3: 《Science China Chemistry》2013年第9期1301-1306,共6页LIANG Jun FANG GeMin HUANG XiuLiang MEI ZiQing LI Juan TIAN ChangLin LIU Lei; National Basic Research Program of China (973 program, 2013CB932800);the National Natural Science Foundation of China (NSFC, 31100524 to M.Z., 31170817 for C.T., and 20972148 to L.L.); The C-terminal conjugate of ubiquitin with 7-amino-4-methylcoumarin （Ub-AMC） is an important probe for fluorescencebased analysis of deubiquitinating enzyme （DUB） activity. It is important to develop more efficien...; 关键词：h the measurement of its DUB activity.ligation of peptide hydrazides peptide segment condensation deubiquitinating enzymes UBIQUITIN

多肽酰肼连接法合成C端香豆素修饰的泛素: 《中国科学：化学》2013年第8期1051-1058,共8页梁军方葛敏黄修良梅子青李娟田长麟刘磊; 国家重点基础研究发展计划(973计划)(2013CB932800);国家自然科学基金(31100524,31170817,20972148)支持; C端用香豆素修饰的泛素分子(Ub-AMC)是研究蛋白质泛素化过程的重要探针.该探针分子的制备目前主要依靠生物表达结合化学修饰的方法,合成效率较低.本文使用多肽酰肼连接反应,发展出化学全合成Ub-AMC分子的新路线.该方法通过N到C顺序两次...; 关键词：酰肼连接反应多片段连接去泛素化酶泛素

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