The study was supported by research grants from National Natural Science Foundation of China(Grant Nos.30830038,30970842,81071180,30900756 and 31270032);the National Basic Research Program(973 Program)(No.2012CB932604);New Drug Discovery Project(2012ZX09506-001-005);Key Project of Science and Tech-nology Commission of Shanghai Municipality(No.10JC1410000);Shanghai Leading Academic Discipline Project(No.S30203)。
SI RT6 is an important histone modifying protein that regulates DNA repair,telomere maintenance,energy me-tabolism,and target gene expression.Recently SIRT6 has been identifi ed as a tumor suppressor and is down-regul...