国家重点基础研究发展计划(2013CB932502)

作品数：6被引量：42H指数：3
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相关作者：黄容琴朱建华更多>>
相关机构：复旦大学更多>>
相关期刊：《核技术》《药学研究》《Acta Pharmaceutica Sinica B》《Frontiers of Chemical Science and Engineering》更多>>
相关主题：BIOMIMETICINFLAMMATIONTARGETINGPROTEINSLIGANDS更多>>
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Improved method for synthesis of low molecular weight protamine–siRNA conjugate被引量：3
《Acta Pharmaceutica Sinica B》2018年第1期116-126,共11页Zhili Yu Junxiao Ye Xing Pei Lu Sun Ergang Liu Jianxin Wang Yongzhuo Huang Seung Jin Lee Huining He 
sponsored in part by National Key Research and Development Plan (2016YFE0119200);partially supported by the National Natural Science Foundation of China (NSFC) on Grants 81402856 and 81361140344 (A3 project);Tianjin Municipal Science and Technology Commission (Grant 15JCYBJC28700);the National Key Basic Research Program of China (Grant 2013CB932502)
RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular ...
关键词：Cell penetrating peptide SIRNA CONJUGATE Conjugation yield Biomimetic delivery CROSSLINKER 
Biomimetic nanoparticles for inflammation targeting被引量：33
《Acta Pharmaceutica Sinica B》2018年第1期23-33,共11页Kai Jin Zimiao Luo Bo Zhang Zhiqing Pang 
supported by the National Natural Science Foundation of China (81472757, 81773283, 81361140344, 81600175 and 81671815);the National Basic Research Program of China (973 Program, 2013CB932502)
There have been many recent exciting developments in biomimetic nanoparticles for biomedical applications. Inflammation, a protective response involving immune cells, blood vessels,and molecular mediators directed aga...
关键词：Biomimetic nanoparticles Inflammation targeting Immune cells Targeting ligands Cell membrane Cell membrane proteins Molecular imaging 
生物可降解无机介孔纳米材料研究进展被引量：1
《药学研究》2017年第4期222-225,共4页李诚意 黄容琴 
国家自然科学基金面上项目(No.81573002);国家重点基础研究发展计划(No.2013CB932502)
近年来,无机介孔纳米材料由于比表面积大、孔结构有序可控、比孔容大等优秀性质而受到化学、材料、物理、医药等领域科研人员重点关注。但在生物临床诊疗应用中,无机介孔纳米材料在机体内的相对难降解、排泄也是亟待解决的问题。本文将...
关键词：纳米材料 介孔硅 介孔钙 生物可降解性 
[^(18)F]FPTZFA的合成及显像研究
《核技术》2015年第2期16-21,共6页周达鸣 朱建华 
国家重点基础研究发展973计划(No.2013CB932502)资助
为研究正电子核素18F标记的叶酸衍生物([18F]FPTZFA)的合成及其在小鼠体内的生物学分布,以叶酸为起始原料,通过叶酸上羧基与2-叠氮基乙胺上氨基的成酯反应,将叠氮基团标记至叶酸,得到γ-叶酸-2-叠氮基乙酰胺(FA-N3);同时以硝基羟基吡啶...
关键词：^18F 叶酸 点击化学反应 
Overcoming oral insulin delivery barriers： application of cell penetrating peptide and silica-based nanoporous composites被引量：3
《Frontiers of Chemical Science and Engineering》2013年第1期9-19,共11页Huining HE Junxiao YE Jianyong SHENG Jianxin WANG Yongzhuo HUANG Guanyi CHEN Jingkang WANG Victor C YANG 
Oral insulin delivery has received the most attention in insulin formulations due to its high patient compliance and, more importantly, to its potential to mimic the physiologic insulin secretion seen in non-diabetic ...
关键词：INSULIN cell penetrating peptide mucoadhesive composites oral delivery 
Ultrasound-mediated targeted microbubbles： a new vehicle for cancer therapy被引量：2
《Frontiers of Chemical Science and Engineering》2013年第1期20-28,共9页Junxiao YE Huining HE Junbo GONG Weibing DONG Yongzhuo HUANG Jianxin WANG Guanyi CHEN Victor C YANG 
With the hope of overcoming the serious side effects, great endeavor has been made in tumor-targeted chemotherapy, and various drug delivery modalities and drug carriers have been made to decrease systemic toxicity ca...
关键词：ultrasound-mediated targeted microbubbles CANCER 
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