国家自然科学基金(30873170)

作品数:3被引量:0H指数:0
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相关作者:张强张烜段瑀王欣余克富更多>>
相关机构:北京大学更多>>
相关期刊:《Journal of Chinese Pharmaceutical Sciences》更多>>
相关主题:TARGETINGNGRLGAIN_VITROG-P更多>>
相关领域:医药卫生更多>>
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Anti-tumor efficiency of NGR-modified PEG-PLGA micelles containing paclitaxel:in vitro and in vivo
《Journal of Chinese Pharmaceutical Sciences》2012年第1期40-49,共10页Bing-Xiang Zhao Yue Huang Li-Min Luo Xin Zhao Xin Wang Su Chen Ke-Fu Yu Xuan Zhang Qiang Zhang 
National Natural Science Foundation of China (Grant No.30873170)
In the present study, we prepared novel NGR-modified PEG-PLGA polymeric micelles containing paclitaxel (NGR- PM-PTX) in order to evaluate their potential targeting to aminopeptidase N receptors expressed on tumor en...
关键词:Aminopeptidase N Asn-Gly-Arg PACLITAXEL TARGETING Polymeric micelles 
Effects of dichloroacetate on the activation of the mitochondrial pathway in C6 cells in vitro
《Journal of Chinese Pharmaceutical Sciences》2011年第5期460-465,共6页赵欣 王欣 余克富 段瑀 李捷思 赵炳祥 张烜 张强 
National Natural Science Foundation of China (Grant No.30873170);the National Basic Research Program of China(973 Program 2007CB935800 and 2009CB930300)
Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate (DCA), a low molecular weight mitochond...
关键词:Mitochondria metabolism DICHLOROACETATE C6 glioma Pyruvate dehydrogenase Reactive oxygen species Mitochondrial membrane potential 
A comparison study of the targeting properties of NGR-liposomes and RGD-liposomes towards human umbilical vein endothelial cells
《Journal of Chinese Pharmaceutical Sciences》2009年第2期162-169,共8页陈晓梅 王珣 黄跃 张烜 张强 
National Natural Science Foundation of China (Grant No. 30873170)
Endothelial cells in the angiogenic vessels of solid tumors over-express several proteins, which could be recognized by some peptide ligands. In this study, the targeting properties of two peptides, RGD (arginine-gly...
关键词:NGR RGD Human umbilical vein endothelial cells Liposomes 
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