国家自然科学基金(30325011)

作品数：7被引量：28H指数：2
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相关作者：苏惟恒冯学超张引红刘田福麻彤辉更多>>
相关机构：东北师范大学山西医科大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《激光生物学报》《Acta Pharmacologica Sinica》《Science Bulletin》更多>>
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AQP1真核表达载体的构建及其在FRT细胞的表达
《激光生物学报》2010年第4期475-478,474,共5页张引红 刘田福 冯学超 苏惟恒 麻彤辉 
国家自然科学杰出青年基金项目(30325011)
目的:构建小鼠AQP1基因真核表达质粒并观察其在FRT细胞中的表达。方法:采用RT-PCR方法从小鼠肾脏组织的总cDNA中扩增出小鼠的AQP1基因,采用基因重组技术将AQP1的cDNA片段插入真核表达载体pCAGGS,构建小鼠AQP1的真核表达质粒,脂质体转染...
关键词：水通道蛋白1 载体构建 表达 
Remarkably Decreased CD11b Positive Splenocytes in Aquaporin 3-Null Mice
《Chemical Research in Chinese Universities》2010年第2期217-220,共4页ZHU Na QIAO Ying ZHANG Di WANG Wen-juan LIU Jia LIU Tian-zhou MA Tong-hui 
Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405, 30570864,30670477 and 30770493);the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011)
Aquaporins（AQPs） are molecular water channels that play important physiological roles in fluid trans-porting organs. The expression and function of AQPs in the immune system are largely unknown. CD 11 （a-d）/CD18 i...
关键词：AQUAPORIN SPLENOCYTE CD1 lb Flow cytometry 
Natural Compound Curcumin—a Channel Potentiator Rather Than a Corrector of the Defective Intracellular Processing of △F508 Mutant Cystic Fibrosis Transmembrane Conductance Regulator被引量：1
《Chemical Research in Chinese Universities》2008年第2期200-203,共4页LIU Xin GUAN Li HE Cheng-yan ZHANG Xiao-jing XU Li-na SHANG De-jing MA Tong-hui YANG Hong 
Supported by the National Natural Science Foundation for Distinguished Young Scholars(No30325011);National Natural Science Foundation of China(Nos30570864 and 30670477);Program for New Century Excellent Talents in University(No NCET-07-0406)
Cystic fibrosis（CF） is a severe genetic disease caused by the gene mutation of the cystic fibrosis transmembrane conductance regulator（CFTR） chloride channel. The most common point mutation AF508, which leads to i...
关键词：Cystic tibrosis CFTR Mutation Natural compound Drug discovery 
Natural Compound Curcumin Corrects the Gating Defect of G551DMutant Cystic Fibrosis Transmembrane Conductance Regulator
《Chemical Research in Chinese Universities》2008年第1期92-95,共4页HAO Li-ming LIU Xin XU Li-na ZHU Na LIN Sen HOU Shu-guang ZHOU Na SHI De-cheng SHANG De-jing MA Tong-hui YANG Hong 
National Natural Science Fund for Distinguished Young Scholars(No.30325011);National Natural Science Foundation of China(Nos.30470405, 30570864, 30670477);Distinguished Young Scholars Fund of Jilin Province (No.20030112) ;Excellent Young Teachers Program of Ministry of Education, China
In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore...
关键词：Cystic fibrosis CFTR MUTATION Natural compound ACTIVATOR 
Importance of NPA motifs in the expression and function of water channel aquaporin-1被引量：1
《Chinese Science Bulletin》2007年第6期771-776,共6页JIANG Yong MA TongHui 
Supported by the National Natural Science Foundation of China for Distinguished Young Scholars (Grant No. 30325011);National Natural Science Foundation of China (Grant Nos. 30470405 and 30670477);Distinguished Young Scholars Fund of Jilin Province (Grant No. 20030112);Excellent Young Teachers Program of Ministry of Education of China
The asparagine-proline-alanine sequences (NPA motifs) are highly conserved in aquaporin water channel family. Crystallographic studies of AQP1 structure demonstrated that the two NPA motifs are in the narrow central c...
关键词：水通道蛋白-1 NPA模体 基因表达 功能 突变发生 
Expression of aquaporin-1 in SMMC-7221 liver carcinoma cells promotes cell migration被引量：5
《Chinese Science Bulletin》2006年第20期2466-2471,共6页LI Yongming FENG Xuechao YANG Hong MA Tonghui 
the National Natural Science Fund for Distinguished Young Scholars （Grant No. 30325011）; National Natural Science Foundation of China （Grant No. 30470405）; Distinguished Young Scholars Fund of Jilin Province （Grant No. 20030112）; Excellent Young Teachers Program of Ministry of Education of China.
Migration of tumor cells is a crucial step in tumor invasion and metastasis. Here we provide evidence that aquaporin expression is involved in tumor cell migration. RT-PCR, immunofluorescence and Western blot analysis...
关键词：细胞迁移 瘤转移 细胞容积 肝肿瘤 SMMC-7221 
Aquaporins as potential drug targets被引量：21
《Acta Pharmacologica Sinica》2006年第4期395-401,共7页Fang WANG Xue-chao FENG Yong-ming LI Hong YANG Tong-hui MA 
Project supported by the National Natural Science Foundation for Distinguished Young Scholars(No 30325011);National Natural Science Foundation(No 30470405);Distinguished Young Scholars Foundation of Jilin Province(No 20030112);Excellent Young Teachers Program of Ministry of Education,China.
The aquaporins （AQP） are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen mammalian AQP have been molecularly iden...
关键词：AQUAPORINS membrane water permeability fluid transport MUTATION gene knockout gene function human disease drug discovery 
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