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国家自然科学基金(30771113): 作品数：13被引量：79H指数：6; 导出分析报告; 相关作者：王大勇沈露露汪洋贺可文张燕芬更多>>; 相关机构：东南大学更多>>; 相关期刊：《Neuroscience Bulletin》《中华预防医学杂志》《生理科学进展》《生态毒理学报》更多>>; 相关主题：CAENORHABDITIS_ELEGANS秀丽线虫NEMATODELIFESPANTIE更多>>; 相关领域：生物学环境科学与工程医药卫生轻工技术与工程更多>>

Confirmation of combinational effects of calcium with other metals in a paper recycling mill effluent on nematode lifespan with toxicity identification evaluation method被引量：6: 《Journal of Environmental Sciences》2010年第5期731-737,共7页Dayong Wang,Yang Wang,Lulu Shen Key Laboratory of Developmental Genes and Human Disease in Ministry of Education,Department of Genetics and Developmental Biology,Southeast University Medical School,Nanjing 210009,China.; supported by the National Natural Science Foundation of China (No. 30771113,30870810);the Program for New Century Excellent Talents in University;provided by the Caenorhabditis Genetics Center (Funded by the NIH,National Center for Foundation from Research Resource,USA); We used toxicity identification evaluation （TIE） method to confirm the combinational effects of identified toxic metals in a paper recycling mill effluent in inducing the decreased lifespan in nematode Caenorhabditi...; 关键词：LIFESPAN CALCIUM combinational toxicity toxicity identification evaluation （TIE） Caenorhabditis elegans

Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion: 《Neuroscience Bulletin》2010年第2期91-103,共13页沈露露杜敏林兴凤蔡婷王大勇; supported by the National Natural Science Foundation of China (No. 30771113,30870810);the Program for New Century Excellent Talents in University; Objective To investigate the interaction between the genes required for the functions of AWA olfactory neuron and insulin/IGF signaling in regulating the longevity of nematode Caenorhabditis elegans （C. elegans）. Me...; 关键词：LONGEVITY ODR-7 AWA olfactory neuron insulin/IGF signaling genetic interaction C. elegans

UNC-64 and RIC-4,the plasma membrane-associated SNAREs syntaxin and SNAP-25,regulate fat storage in nematode Caenorhabditis elegans: 《Neuroscience Bulletin》2010年第2期104-116,共13页武秋立芮琪贺可文沈露露王大勇; supported by the grants from the National Natural Science Foundation of China(No. 30771113, 30870810);the Program for New Century Excellent Talents in University; Objective To investigate whether genes required for synaptogenesis and synaptic function are also involved in fat storage control in Caenorhabditis elegans. Methods Fat storage was examined in mutants of genes affecti...; 关键词：fat storage synaptic function UNC-64 RIC-4 Caenorhabditis elegans

Adverse effects of metal exposure on chemotaxis towards water-soluble attractants regulated mainly by ASE sensory neuron in nematode Caenorhabditis elegans被引量：5: 《Journal of Environmental Sciences》2009年第12期1684-1694,共11页XING Xiaojuan, DU Min, ZHANG Yanfen, WANG Dayong Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Department of Genetics and Developmental Biology, Southeast University Medical School, Nanjing 210009, China.; supported by the National Natural Science Foundation of China (No. 30771113, 30870810);the Program for New Century Excellent Talents in University;provided by the Caenorhabdits Genetics Center (funded by the NIH National Center for Research Resource, USA).; Chemotaxis to water-soluble attractants is mainly controlled by ASE sensory neuron whose specification is regulated by che-1 in Caenorhabditis elegans. Our data suggested that exposure to high concentrations of metals...; 关键词：CHEMOTAXIS water-soluble attractant ASE neuron che-1 Caenorhabditis elegans

Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis defects by microcystin-LR exposure in nematode Caenorhabditis elegans被引量：2: 《Journal of Environmental Sciences》2009年第7期971-979,共9页LI Yunhui YE Huayue DU Min ZHANG Yanfen YE Boping PU Yuepu WANG Dayong; supported by the National Natural Sci- ence Foundation of China (No. 30771113, 30870810)and the Program for New Century Excellent Talents in University;provided by the Caenorhabditis Genetics Center (funded by the NIH, National Center for Foundation from Research Resource); Apart from the liver disruption, embryotoxicity and genotoxicity, microcystin （MC）-LR also could cause neurotoxicity. Nematode Caenorhabditis elegans was explored as a model to study the neurotoxicity. In the presen...; 关键词：MC-LR CHEMOTAXIS THERMOTAXIS neurotoxicity Caenorhabditis elegans

Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent被引量：2: 《Neuroscience Bulletin》2009年第6期335-342,共8页贺可文沈露露周文文王大勇; supported by grants from the National Natural Science Foundation of China (No.30771113, 30870810);the Program for New Century Excellent Talents in University;the Innovative Research Program for Undergraduates in China (No. C2007052); Objective To investigate the role of environmental factor—temperature in the regulation of aging process by unc-13 and sbt-1 in Caenorhabditis elegans. Methods The lifespan, the speed of pharynx pumping, and the inte...; 关键词：AGING unc-13 sbt-1 TEMPERATURE-DEPENDENT synaptic function C. elegans

Prolonged manganese exposure induces severe deficits in lifespan,development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans被引量：13: 《Journal of Environmental Sciences》2009年第6期842-848,共7页XIAO Jing RUI Qi GUO Yuling CHANG Xingya WANG Dayong; supported by the National Natural Science Foundation of China (No. 30771113, 30870810);the Program for New Century Excellent Talents in University; We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese（Mn） solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our dat...; 关键词：manganese toxicity prolonged exposure stress response antioxidant gene Caenorhabditis elegans

秀丽线虫脂肪积累调控的生理与分子机制被引量：5: 《生理科学进展》2009年第2期129-134,共6页许雪梅王大勇; 国家自然科学基金(30771113);教育部新世纪优秀人才项目基金资助课题; 脂肪积累是一个复杂的生理过程,模式动物秀丽线虫(以下简称线虫)已经成为目前研究脂肪积累的重要模型。线虫中的脂肪酸代谢通路与其他物种中的代谢是基本一致的,很多关键的代谢调节基因的功能已经得到鉴定。线虫中脂肪积累涉及至少4个...; 关键词：秀丽线虫脂肪积累生理调控分子机制

HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans: 《Neuroscience Bulletin》2009年第2期75-86,共12页王大勇汪洋; the National Natural Science Foundation of China (No. 30771113, 30870810);the Program for New Century Excellent Talents in University, Ministry of Education, China; Objective To study the role of HLB-1 in regulating the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans. Methods To evaluate the functions of HLB-1 in regulating the organization...; 关键词：HLB-1 synaptic function neuromuscular junction SYD-2 Caenorhabditis elegans

秀丽线虫衰老调控的生理与分子机制被引量：7: 《生理科学进展》2009年第1期75-78,共4页沈露露王大勇; 国家自然科学基金(30771113);教育部新世纪优秀人才项目基金资助课题; 秀丽线虫(Caenorhabditis elegans)是目前研究动物衰老调控机制重要模型之一。在线虫中,众多的信号通路经相互协同形成的复杂网络接受来自感觉神经元的各种环境信息,进而通过信号传递作用于各组织器官而影响衰老的诸多方面。线虫衰老的...; 关键词：衰老生理调控分子机制秀丽线虫

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