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国家自然科学基金(20890112): 作品数：15被引量：84H指数：7; 导出分析报告; 相关作者：朱本占周群芳梁勇王静杜宇国更多>>; 相关机构：中国科学院生态环境研究中心华中农业大学江汉大学山东省医学科学院更多>>; 相关期刊：《波谱学杂志》《科学通报》《环境科学学报》《Science China Chemistry》更多>>; 相关主题：溴化阻燃剂异氰脲酸酯TNFΑFLUORESCENCE持久性有机污染物更多>>; 相关领域：生物学环境科学与工程理学医药卫生更多>>

持久性有机污染物致胰岛素抵抗及其潜在病理机制被引量：8: 《生态毒理学报》2013年第6期817-823,共7页王静杜宇国; 国家自然科学基金(20890112,21077127);国家重点基础研究发展计划(2009CB421605,2008CB418102); 胰岛素抵抗综合症目前在全世界以惊人的速度增长,成为21世纪公共健康的严重挑战。多例流行病学调查结果已经显示持久性有机污染物与胰岛素抵抗的关联。胰岛素信号传递受损是胰岛素抵抗的本质原因。考察机制发现,可在机体脂肪组织中贮存...; 关键词：胰岛素抵抗持久性有机污染物细胞受体 TNFΑ 信号转导

Development of indirect competitive fluorescence immunoassay for 2,2′,4,4′-tetrabromodiphenyl ether using DNA/dye conjugate as antibody multiple labels: 《Journal of Environmental Sciences》2012年第7期1334-1340,共7页Zi-Yan Fan Young Soo Keum Qing-Xiao Li Weilin L.Shelver Liang-Hong Guo; supported by the Chinese Academy of Sciences (No. KSSCX2-YW-G-059);the National Hi-Tech Research and Development Program of China (No.2007AA06A407);the National Natural Science Foundation of China (No. 20825519, 20890112, 20921063); An indirect competitive fluorescence immunoassay using a DNA/dye conjugate as antibody multiple labels was developed on 96-well plates for the identification and quantification of 2,2＇,4,4＇-tetrabromodiphenyl ether ...; 关键词：polybrominated diphenyl ethers fluorescence immunoassay MICROPLATE multiple labeling

An E. coli SOS-EGFP biosensor for fast and sensitive detection of DNA damaging agents被引量：2: 《Journal of Environmental Sciences》2012年第3期541-549,共9页Zhilan Chen Meiling Lu Dandan Zou Hailin Wang; supported by the National Natural Science Foundation of China (No. 20707034, 20877091,20890112, 20921063);the National Basic Research Program (973) of China (No. 09CB421605,2010CB933500, 2011CB936001); An E. coli SOS-EGFP biosensor which expresses enhanced green fluorescent protein as a reporter protein under the control of recA gene promoter in SOS response was constructed for detection of DNA damage and evaluation...; 关键词：bacterial biosensor detection DNA damage GENOTOXINS SOS response

三-(2,3-二溴丙基)异氰脲酸酯和17β-雌二醇复合暴露对雄性斑马鱼的毒性效应被引量：9: 《环境科学学报》2012年第2期450-456,共7页张续黎娟刘雅思陈曦张捷周群芳梁勇; 国家自然科学基金项目(No.20890112);国家重点基础研究发展计划项目(No.2009CB421605);环境化学与生态毒理学国家重点实验室开放基金项目(No.KF2009-05)~~; 三-(2,3-二溴丙基)异氰脲酸酯(TBC)是近年来在环境中新检测到的一种杂环溴化阻燃剂,但其毒性效应尚不明确.我们以雄性斑马鱼为受试动物,开展了TBC和17β-雌二醇(E2)的复合暴露实验,以研究TBC潜在的致毒机制.结果显示TBC可显著抑制E2所...; 关键词：溴化阻燃剂三-(2 3-二溴丙基)异氰脲酸酯斑马鱼卵黄蛋白原内分泌干扰物

三种纳米金颗粒对聚合酶链式反应扩增效率和特异性的影响被引量：5: 《环境化学》2012年第1期1-8,共8页姚晶林燕李佳周群芳梁勇; 国家自然科学基金(20907017,20890112);国家重点基础研究发展项目(973)(2009CB421605)的资助; 比较了采用柠檬酸三钠(Trisodium citrate,Na3Ct)还原法、聚乙烯吡咯烷酮(Polyvinylpyrrolidone,PVP)包裹法和巯基丙酸-同型半胱氨酸(Mercaptopropionic Acid-Homocystine,MPA-HCys)包裹法制备的3种纳米金颗粒(Gold nanoparticles,AuNPs...; 关键词：AuNPs PCR 效率特异性 DNA

Induced temperature-dependent DNA degradation by C_(60) without photoactivation: 《Chinese Science Bulletin》2011年第28期3100-3107,共8页WANG Chang LIN Yan WANG Ying LIANG Yong MENG LingZhi ZHANG Jie ZHOU QunFang JIANG GuiBin; the National Natural Science Foundation of China (20907017, 20890112);the National Basic Research Program of China (2009CB421605);the National High Technology Research and Development Program of China (2007BAC27B01); This study shows that C_(60) can degrade pBR322 plasmid DNA at room temperature without photoactivation. The degradation was enhanced by increasing incubation temperature, reaction time or C_(60) concentration. We als...; 关键词：质粒DNA 可降解温度依赖超氧化物歧化酶 DNA裂解 DNA降解 DNA构象 PBR322

Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)被引量：14: 《Chinese Science Bulletin》2011年第15期1548-1555,共8页ZHANG Xu LI Juan CHEN MinJie WU Le ZHANG Chi ZHANG Jie ZHOU QunFang LIANG Yong; supported by the National Natural Science Foundation of China (20890112 and 20907017);the National Basic Research Program of China (2009CB421605);the National High Technology R&D Program of China (2007BAC27B01);State Key Laboratory of Environmental Chemistry and Ecotoxicology (KF2009-05); Tris-(2,3-dibromopropyl) isocyanurate (TBC) is a heterocyclic brominated flame retardant that was recently detected in the environment in China.TBC is semi-volatile and can accumulate in the lipid of some species,but ...; 关键词：溴化阻燃剂异氰脲酸酯毒性作用斑马鱼超氧化物歧化酶活性丙基二溴基因表达

持久性有机污染物致糖尿病潜在病理机制被引量：2: 《中华预防医学杂志》2011年第5期456-458,共3页焦守海王静季虹荣海钦杜宇国; 基金项目：国家重点基础研究发展计划（2008CB418102,2009CB421605）;国家自然科学基金（20890112,21077127）; 糖尿病是由于胰岛素分泌不足和（或）胰岛素抵抗而引起的糖、脂、蛋白质和水电解质紊乱的代谢性疾病，以高血糖为其主要特征。世界卫生组织（WHO）将糖尿病分为4类，即1型、2型、妊娠型糖尿病和其他特殊类型糖尿病，; 关键词：特殊类型糖尿病持久性有机污染物病理机制胰岛素分泌不足水电解质紊乱世界卫生组织胰岛素抵抗代谢性疾病

Troglitazone Induced Apoptosis via PPARγ Activated POX-induced ROS Formation in HT29 Cells被引量：1: 《Biomedical and Environmental Sciences》2011年第4期391-399,共9页WANG Jing LV XiaoWen SHI JiePing HU XiaoSong DU YuGuo; supported by the National Basic Research Program (973) of China (No. 2009CB421605, No.2008CB418102);the National Natural Science Foundation of China (No.20890112, No. 21077127); Objective In order to investigate the potential mechanisms in troglitazone-induced apoptosis in HT29 cells,the effects of PPARγ and POX-induced ROS were explored.Methods [3-（4,5）-dimethylthiazol-2-yl]-2,5-diphenylt...; 关键词：TROGLITAZONE Apoptosis HT29 POX ROS formation PPARΓ Cytochrome c release

In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A被引量：8: 《Journal of Environmental Sciences》2011年第2期315-321,共7页Jie Cao Liang-Hong Guo Bin Wan Yin Wei; supported by the National Natural Science Foundation of China(No. 20890112,20921063,20825519); Bisphenol A （BPA） is a chemical with high production volume and wide applications in many industries. Although BPA is known as an endocrine disruptor, its toxic mechanisms have not been fully characterized. Due to i...; 关键词：bisphenol A human serum albumin human transthyretin human thyroxine-binding globulin fluorescence displacement method

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