《Virologica Sinica》

作品数:1567被引量:3827H指数:21
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《Virologica Sinica》
主办单位:中国科学院武汉病毒研究所;中国微生物学会
最新期次:2024年6期更多>>
发文主题:VIRUSSARS-COVINFECTIONVIRALVACCINE更多>>
发文领域:医药卫生农业科学生物学文化科学更多>>
发文作者:庞义袁志明余健秀张用梅陈新文更多>>
发文机构:中国科学院中山大学华中农业大学中国农业科学院生物防治研究所更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Ten computational challenges in human virome studies
《Virologica Sinica》2024年第6期845-850,共6页Yifan Wu Yousong Peng 
supported by National Natural Science Foundation of China(32170651&32370700).
In recent years,substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases.Despite this progress,the field of human virome resea...
关键词:Human virome Computational biology Computational viromics Artificial intelligence 
Viral load dynamics in asymptomatic and symptomatic patients during Omicron BA.2 outbreak in Shanghai,China,2022:A longitudinal cohort study
《Virologica Sinica》2024年第6期851-859,共9页Jingwen Ai Jiaxin Zhou Yang Li Feng Sun Shijia Ge Haocheng Zhang Yanpeng Wu Yan Wang Yilin Zhang Hongyu Wang Jianpeng Cai Xian Zhou Sen Wang Rong Li Zhen Feng Xiangyanyu Xu Xuemei Yan Yuchen Zhao Juanjuan Zhang Hongjie Yu Wenhong Zhang 
financial support from the Key Program of the National Natural Science Foundation of China(82130093);Wenhong Zhang,Juanjuan Zhang acknowledge financial support from Shanghai Municipal Science and Technology Major Project(HS2021SHZX001);Wenhong Zhang acknowledges financial support from the Key Program of the National Natural Science Foundation of China(82161138018 and 82041010);Shanghai Science and Technology Committee(20dz2260100,20Z11901100);Shanghai Hospital Development Center(SHDC2020 CR5010-002).
The SARS-CoV-2 virus,particularly the Omicron BA.2 variant,led to a significant surge in Shanghai,2022.However,the viral load dynamic in Omicron infections with varying clinical severities remain unclear.This prospect...
关键词:COVID-19 Omicron BA.2 Viral load dynamics Viral shedding time 
Single-cell RNA sequencing reveals the diversity of the immunological landscape response to genital herpes
《Virologica Sinica》2024年第6期860-874,共15页Siji Chen Jiang Zhu Chunting Hua Chenxi Feng Xia Wu Can Zhou Xianzhen Chen Boya Zhang Yaohan Xu Zeyu Ma Jianping He Na Jin Yinjing Song Stijn van der Veen Hao Cheng 
supported by grants from the National Natural Science Foundation of China[grant number 82471846,82103740 and 82103743];Medical Science and Technology Project of Zhejiang Province[grant number 2022RC198].
Genital herpes(GH)is a common sexually transmitted disease,which is primarily caused by herpes simplex virus type 2(HSV-2),and continues to be a global health concern.Although our understanding of the alterations in i...
关键词:Single-cell RNA sequencing(scRNA-seq) Genital herpes(GH) Herpes simplex virus(HSV) Immune response 
The first discovery of severe fever with thrombocytopenia virus in the center of metropolitan Beijing,China
《Virologica Sinica》2024年第6期875-881,共7页Fei Yuan Lianglong Zhu Di Tian Mengyu Xia Ming-hao Zheng Qing Zhang Tingyu Zhang Xing Zhang Aihua Zheng 
supported by the National Key R&D Program of China(2021YFC2300903 and 2022YFC2601603);the Open Research Fund Program of State Key Laboratory of Integrated Pest Management(IPM2315).
Severe fever with thrombocytopenia virus(SFTSV),an emerging tick-borne bandavirus,poses a significant public health threat in rural China.Since 2021,an increase of local cases has been noted in the rural-urban fringe ...
关键词:Severe fever with thrombocytopenia virus(SFTSV) HEDGEHOG Haemaphysalis longicornis Urban Beijing 
Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters被引量:1
《Virologica Sinica》2024年第6期909-916,共8页Shaohong Chen Xinghai Zhang Yanfeng Yao Shengdong Wang Kangyin Li Baoyue Zhang Tianxi Ye Li Chen Yan Wu Entao Li Bichao Xu Pei Zhang Xia Chuai Yong Ran Rui Gong Huajun Zhang Sandra Chiu 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0490000).
Nipah virus(NiV)is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia.NiV leads to severe respiratory disease and encephalitis in humans and animals,with a mortality rate of up to 75...
关键词:Nipah virus(NiV) Ferritin nanoparticles Vaccine candidate 
Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening
《Virologica Sinica》2024年第6期917-928,共12页Song-Kang Qin Kuan-Hao Li Ben-Jin Liu Cun Cao De-Bin Yu Zhi-Gang Jiang Jun Wang Yu-Xin Han Fang Wang Ying-Lin Qi Chao Sun Li Yu Ji-Tao Chang Xin Yin 
supported by the Heilongjiang Provincial Natural Science Foundation of China(grant no.LH2033C107);the National Key Research and Development Program of China(2023YFD1801302);the Central Public-interest Scientific Institution Basal Research Fund(grant no.1610302022010).
Unveiling the molecular mechanisms underlying rotavirus replication and pathogenesis has been hampered by the lack of a reverse genetics(RG)system in the past.Since 2017,multiple plasmid-based RG systems for simian,hu...
关键词:Bovine rotavirus(BRV) Optimized reverse genetics system Reporter virus High-throughput screen Small chemical compound 
Generation and characterization of a novel ovariole cell line derived from Spodoptera frugiperda in China with sensitivity to both SfMNPV and AcMNPV
《Virologica Sinica》2024年第6期929-937,共9页Yan Tong Wenyi Jin Xuan Li Lin Guo Gang Luo Qian Meng Jihong Zhang Qilian Qin Huan Zhang 
funded by the National Key Research and Development Program of China(Grant number 2022YFD1400700);Initiative Scientific Research Program,Institute of Zoology,Chinese Academy of Sciences(Grant number 2023IOZ010).
Spodoptera frugiperda multiple nucleopolyhedrovirus(SfMNPV),belonging to the species Alphabaculovirus spofrugiperdae,has been recently registered as an insecticide in China.This virus has a specific effect on the glob...
关键词:Spodoptera frugiperda multiple nucleopolyhedrovirus(SfMNPV) Autographa californica multiple nucleopolyhedrovirus(AcMNPV) Spodoptera frugiperda Mitochondrial COX1 Insect ovarian cell line 
Modulation of the unfolded protein response by white spot syndrome virus via wsv406 targeting BiP to facilitate viral replication
《Virologica Sinica》2024年第6期938-950,共13页Shihan Chen Qiqi Zhong Xuzheng Liao Haiyang Wang Bang Xiao Jianguo He Chaozheng Li 
supported by the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(SML2023SP234);National Natural Science Foundation of China(32022085/32373158/31930113);the open competition program of top ten critical priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(2022SDZG01).
Outbreaks of diseases are often linked to environmental stress,which can lead to endoplasmic reticulum(ER)stress and subsequently trigger the unfolded protein response(UPR).The replication of the white spot syndrome v...
关键词:SHRIMP White spot syndrome virus Unfolded protein response wsv406 Binding protein(BiP) 
Case study:May human norovirus infection be associated with premature delivery?
《Virologica Sinica》2024年第6期951-962,共12页Jiaying Cao Yuetong Li Feiyang Xue Ziyang Sheng Libo Liu Yingying Zhang Lele Wang Liang Zeng Yanmin Jiang Dongying Fan Fang Li Jing An 
supported by the National Natural Science Foundation of China(No.82241071,32370163&32400134);National Key Research and Development program(2019YFC0121905).
Human norovirus(HuNoV)is the leading cause of acute gastroenteritis.The varying severity of chronic infection in patients with underlying immune deficiencies poses additional burdens on public health.However,the poten...
关键词:Human norovirus(HuNoV) Adverse pregnancy outcome Premature delivery Premature rupture of membranes Virus infection 
Construction and validation of a mouse model for studying severe human adenovirus infections
《Virologica Sinica》2024年第6期963-973,共11页Dingbin Chen Yuqian Yan Ting Mei Peipei Yang Siqi Deng Yiqiang Li Tie Zhao Ning Xin Biyan Duan Weifeng Liang Yuemei Yang Wei Zhao Donald Seto Junxian Ou Qiwei Zhang 
supported by grants from the National Natural Science Foundation of China(32170139 and 92269103);the R&D Program of Guangzhou Laboratory(No.SRPG22-006);the Guangdong Basic and Applied Basic Research Foundation(2022A1515011190);the Science and Technology Program of Guangzhou,China(202201011115);the Open Foundation of Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University),Ministry of Education(2023VPPC-R07);China Postdoctoral Science Foundation(2023M731321);the Lifting Project Foundation of the Affiliated Guangdong Second Provincial General Hospital of Jinan University(TJGC-2022004).
Human adenoviruses(HAdVs)are highly contagious pathogens with various genotypes implicated in acute respiratory disease(ARD)and linked to fatality,especially in immunosuppressed patients,young children,and military re...
关键词:Human adenovirus type 5(HAdV-5) Animal model BALB/c mice Severe human adenovirus infections 
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