supported by National Natural Science Foundation of China(32170651&32370700).
In recent years,substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases.Despite this progress,the field of human virome resea...
financial support from the Key Program of the National Natural Science Foundation of China(82130093);Wenhong Zhang,Juanjuan Zhang acknowledge financial support from Shanghai Municipal Science and Technology Major Project(HS2021SHZX001);Wenhong Zhang acknowledges financial support from the Key Program of the National Natural Science Foundation of China(82161138018 and 82041010);Shanghai Science and Technology Committee(20dz2260100,20Z11901100);Shanghai Hospital Development Center(SHDC2020 CR5010-002).
The SARS-CoV-2 virus,particularly the Omicron BA.2 variant,led to a significant surge in Shanghai,2022.However,the viral load dynamic in Omicron infections with varying clinical severities remain unclear.This prospect...
supported by grants from the National Natural Science Foundation of China[grant number 82471846,82103740 and 82103743];Medical Science and Technology Project of Zhejiang Province[grant number 2022RC198].
Genital herpes(GH)is a common sexually transmitted disease,which is primarily caused by herpes simplex virus type 2(HSV-2),and continues to be a global health concern.Although our understanding of the alterations in i...
supported by the National Key R&D Program of China(2021YFC2300903 and 2022YFC2601603);the Open Research Fund Program of State Key Laboratory of Integrated Pest Management(IPM2315).
Severe fever with thrombocytopenia virus(SFTSV),an emerging tick-borne bandavirus,poses a significant public health threat in rural China.Since 2021,an increase of local cases has been noted in the rural-urban fringe ...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0490000).
Nipah virus(NiV)is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia.NiV leads to severe respiratory disease and encephalitis in humans and animals,with a mortality rate of up to 75...
supported by the Heilongjiang Provincial Natural Science Foundation of China(grant no.LH2033C107);the National Key Research and Development Program of China(2023YFD1801302);the Central Public-interest Scientific Institution Basal Research Fund(grant no.1610302022010).
Unveiling the molecular mechanisms underlying rotavirus replication and pathogenesis has been hampered by the lack of a reverse genetics(RG)system in the past.Since 2017,multiple plasmid-based RG systems for simian,hu...
funded by the National Key Research and Development Program of China(Grant number 2022YFD1400700);Initiative Scientific Research Program,Institute of Zoology,Chinese Academy of Sciences(Grant number 2023IOZ010).
Spodoptera frugiperda multiple nucleopolyhedrovirus(SfMNPV),belonging to the species Alphabaculovirus spofrugiperdae,has been recently registered as an insecticide in China.This virus has a specific effect on the glob...
supported by the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(SML2023SP234);National Natural Science Foundation of China(32022085/32373158/31930113);the open competition program of top ten critical priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(2022SDZG01).
Outbreaks of diseases are often linked to environmental stress,which can lead to endoplasmic reticulum(ER)stress and subsequently trigger the unfolded protein response(UPR).The replication of the white spot syndrome v...
supported by the National Natural Science Foundation of China(No.82241071,32370163&32400134);National Key Research and Development program(2019YFC0121905).
Human norovirus(HuNoV)is the leading cause of acute gastroenteritis.The varying severity of chronic infection in patients with underlying immune deficiencies poses additional burdens on public health.However,the poten...
supported by grants from the National Natural Science Foundation of China(32170139 and 92269103);the R&D Program of Guangzhou Laboratory(No.SRPG22-006);the Guangdong Basic and Applied Basic Research Foundation(2022A1515011190);the Science and Technology Program of Guangzhou,China(202201011115);the Open Foundation of Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University),Ministry of Education(2023VPPC-R07);China Postdoctoral Science Foundation(2023M731321);the Lifting Project Foundation of the Affiliated Guangdong Second Provincial General Hospital of Jinan University(TJGC-2022004).
Human adenoviruses(HAdVs)are highly contagious pathogens with various genotypes implicated in acute respiratory disease(ARD)and linked to fatality,especially in immunosuppressed patients,young children,and military re...