《Frontiers of Medicine》

作品数：1289被引量：4223H指数：27
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《Frontiers of Medicine》
主办单位：Higher Education Press, China;Chinese Academy of Engineering, China;Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China
最新期次：2025年1期更多>>
发文主题：HEPATOCELLULAR_CARCINOMATRADITIONAL_CHINESE_MEDICINEPATIENTSIN_CHINACANCER更多>>
发文领域：医药卫生生物学农业科学自动化与计算机技术更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Ferroptosis contributes to immunosuppression
《Frontiers of Medicine》2025年第1期1-22,共22页Nina He Dun Yuan Minjie Luo Qing Xu Zhongchi Wen Ziqin Wang Jie Zhao Ying Liu 
the financial support from the National Natural Science Foundation of China(Nos.82172147,81571880,81373147,30901555,and 30972870);the Natural Science Foundation of Hunan Province(Nos.2021JJ30900 and 2016JJ2157);the Graduate Innovation Project of Central South University(No.2024ZZTS0864).
As a novel form of cell death,ferroptosis is mainly regulated by the accumulation of soluble iron ions in the cytoplasm and the production of lipid peroxides and is closely associated with several diseases,including a...
关键词：ferroptosis IMMUNOSUPPRESSION immune cells 
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer:distinct and concerted control
《Frontiers of Medicine》2025年第1期23-52,共30页Xianzhe Huang Wenwei Chen Yanyan Wang Dmytro Shytikov Yanwen Wang Wangyi Zhu Ruyi Chen Yuwei He Yanjia Yang Wei Guo 
supported by the National Natural Science Foundation of China(Nos.81974455,8217110405,and 82173351);the National Key Research and Development Program of China(No.2018YFA0107800);the Zhejiang University Startup Fund for Dr.Wei Guo.Special thanks also go to the Mu Xian Hua Stem Cells and Cancer Resistance Fund.
Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice.While target mutations are well recognized as the basis of genetic resistance to targeted therapy,nontarget mutation resi...
关键词：canonical NOTCH signaling noncanonical NOTCH signaling nongenetic resistance of cancer cancer stemlike cells epithelial-to-mesenchymal transition drug-tolerant persisters NOTCH inhibitors 
Does the outcome of acupuncture differ according to the location of sham needling points in acupuncture trials for migraine?A systematic review and network meta-analysis
《Frontiers of Medicine》2025年第1期53-63,共11页Boram Lee Chan-Young Kwon Hye Won Lee Arya Nielsen LSusan Wieland Tae-Hun Kim Stephen Birch Terje Alraek Myeong Soo Lee 
supported by the Korea Institute of Oriental Medicine(Nos.KSN2121211 and KSN23314112);LSW was supported by the National Center for Complementary and Integrative Health of the National Institutes of Health(No.R24 AT001293);The funders had no role in the design and conduct of the study,the collection,management,analysis,and interpretation of the data,the preparation,review,and approval of the manuscript,or the decision to submit the manuscript for publication.
Various acupuncture clinical trials have been conducted on migraine;however,the conclusions remain controversial especially when acupuncture was compared with sham acupuncture.Sham acupuncture is sometimes performed a...
关键词：acupuncture therapy MIGRAINE migraine disorders sham acupuncture PLACEBO 
Prevalence and associated risk factors of carotid plaque and artery stenosis in China: a population-based study
《Frontiers of Medicine》2025年第1期64-78,共15页Qingjia Zeng Chongyang Zhang Xinyao Liu Shengmin Yang Muyuan Ma Jia Tang Tianlu Yin Shanshan Zhao Wenjun Tu Hongpu Hu 
Stroke is a critical health issue in China, and carotid artery stenosis and plaque play key roles in its prevalence. Despite the acknowledged significance of this condition, detailed information regarding the prevalen...
关键词：carotid plaque carotid artery stenosis PREVALENCE risk factors Bigdata Observatory Platform for stroke in China 
Gallstones,cholecystectomy,and cancer risk:an observational and Mendelian randomization study
《Frontiers of Medicine》2025年第1期79-89,共11页Yuanyue Zhu Linhui Shen Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei Tang Gang Chen Yu Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Xuejiang Gu Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Weiqing Wang Guang Ning Jieli Lu Min Xu Yufang Bi Weiguo Hu 
funded by the National Natural Science Foundation of China(Nos.82270859,82370819,and 82088102);the National Key R&D Program of China(No.2023YFC2506700);the Shanghai Municipal Government grant(No.22Y31900300);the Shanghai Clinical Research Center for Metabolic Diseases(No.19MC1910100).
This study aimed to comprehensively examine the association of gallstones,cholecystectomy,and cancer risk.Multivariable logistic regressions were performed to estimate the observational associations of gallstones and ...
关键词：GALLSTONE CHOLECYSTECTOMY cancer risk Mendelian randomization 
Allogeneic hematopoietic stem cell transplantation could overcome the poor prognosis of DNMT3A^(mut)NPM1^(mut)FLT3-ITD^(mut)in acute myeloid leukemia:real-world multicenter analysis in China
《Frontiers of Medicine》2025年第1期90-100,共11页Wenxuan Huo Yifan Shen Jiayu Huang Yang Yang Shuang Fan Xiaosu Zhao Qi Wen Luxiang Wang Chuanhe Jiang Yang Cao Xiaodong Mo Yang Xu Xiaoxia Hu 
supported by the National Key Research and Development Program of China(Nos.2022YFC2502600 and 2022YFC2502606);the National Natural Science Foundation of China(Nos.82170206 and 82170208);CAMS Innovation Fund for Medical Sciences(Nos.2019-I2M-5-034 and 2022-I2M-C&T-B-121);Peking University People’s Hospital Research and Development Funds(No.RZ2022-02);Tongzhou District Distinguished Young Scholars(No.JCQN2023009);Shanghai Municipal Health Commission Project of Disciplines of Excellence(No.20234Z0002)。
The cooccurrence of NPM1,FLT3-ITD,and DNMT3A mutations(i.e.,triple mutation)is related to dismal prognosis in patients with acute myeloid leukemia(AML)receiving chemotherapy alone.In this multicenter retrospective coh...
关键词：allogeneic hematopoietic stem cell transplantation acute myeloid leukemia DNMT3A mutation NPMI mutation FLT3-ITD mutation triple mutation 
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer
《Frontiers of Medicine》2025年第1期101-120,共20页Xueyan Shi Sichong Han Guizhen Wang Guangbiao Zhou 
supported by the National Key Research and Development Program of China(Nos.2023YFC3503205 and 2022YFA1103900);the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2022-I2M-1-009);the National Natural Science Foundation of China(Nos.22372944,22073092 nnd 82273076);the Science and Technology Research Project of Henan Province(No.222122316366);the Henan Provincial Medical Science and Technology Research Project(No.LHGJ20210183);the Scientific Research Fund Project of the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital.
Mitochondria are the convergence point of multiple pathways that trigger programmed cell death(PCD).Mitochondrial-associated PCD(mtPCD)is involved in the pathogenesis of several diseases.However,the role of mtPCD in t...
关键词：mitochondrial associated programmed cell death NSCLC PROGNOSIS gene signature 
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer
《Frontiers of Medicine》2025年第1期121-133,共13页Xiaoxia Che Xin Guan Yiyin Ruan Lifei Shen Yuhong Shen Hua Liu Chongying Zhu Tianyu Zhou Yiwei Wang Weiwei Feng 
funded by the National Natural Science Foundation of China(Nos.82172601 and 82303640).
Ovarian cancer is the most lethal malignancy affecting the female reproductive system.Pharmacological inhibitors targeting CDK4/6 have demonstrated promising efficacy across various cancer types.However,their clinical...
关键词：TRIM4 CDK4/6 inhibitor hnRNPDL ovarian cancer 
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction:insights from network pharmacology and implications for atopic dermatitis treatment
《Frontiers of Medicine》2025年第1期134-148,F0004,共16页Keke Huang Qingkai Liu Ruoxi Zhang Hua Nian Ying Luo Yue Luo Xiaoya Fei Le Kuai Bin Li Yimei Tan Su Li Xin Ma 
supported by the National Natural Science Foundation of China(No.82004359);Xinglin Youth Scholar of Shanghai University of Traditional Chinese Medicine(No.RY411.33.10);Youth Talent Promotion Project of China Association of Traditional Chinese Medicine(2021-2023)Category A(No.CACM-2021-QNRC2-A10);Health Young Talents of Shanghai Municipal Health Commission(No.2022YQ026);“Chen Guang”project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation(No.22CGA50);The Clinical Research Plan of SHDC(No.SHDC22022302);High-level Chinese Medicine Key Discipline Construction Project(Integrative Chinese and Western Medicine Clinic)of National Administration of TCM(No.zyyzdxk-2023065);Shanghai Dermatology Research Center(No.2023ZZ02017);Shanghai Dermatology Hospital Demonstration Research Ward Project(No.SHDC2023CRW009);Evidence-based Dermatology Base sponsored by State Administration of Traditional Chinese Medicine,Shanghai Municipal Project for the Construction of Traditional Chinese Medicine Expert Heritage Studio(No.2020ZYGZS-002);Clinical Transformation Incubation Program in Hospital(No.lczh2023-01);Professional Technical Service Platform Construction Project of Shanghai Science and Technology Commission(No.21DZ2294500);Shanghai key Discipline Construction Project of Traditional Chinese Medicine(No.shzyyzdxk-2024104).
To investigate the protective effects and underlying mechanisms of Qin-Zhu-Liang-Xue decoction(QZLX)in atopic dermatitis(AD)and glucocorticoid resistance,we conducted a single-blinded,randomized controlled clinical tr...
关键词：Qin-Zhu-Liang-Xue decoction atopic dermatitis glucocorticoid receptorα traditional Chinese medicine network pharmacology 
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome
《Frontiers of Medicine》2025年第1期149-169,共21页Dongshuang Wang Meiling Zhang Wang-Sheng Wang Weiwei Chu Junyu Zhai Yun Sun Zi-Jiang Chen Yanzhi Du 
supported by grants from the National Key Research and Development Program of China(Nos.2022YFC2703204 and 2021YFC2701104);the National Natural Science Foundation of China(Nos.81971343 and 82171623);the National Institutes of Health Project(No.1R01HD085527),the Innovative research team of high-level local universities in Shanghai(No.SHSMU-ZLCX20210200);Shanghai Commission of Science and Technology(Nos.21XD1401900 and 20DZ2270900);Three-Year Action Plan for Strengthening the Construction of the Public Health System in Shanghai(No.GWVI-11.1-36);Shanghai’s Top Priority Research Center Construction Project(No.2023ZZ02002).
Polycystic ovary syndrome(PCOS)is the predominant cause of subfertility in reproductive-aged women;however,its pathophysiology remains unknown.Neurotensin(NTS)is a member of the gut–brain peptide family and is involv...
关键词：NEUROTENSIN neurotensin receptor 1 early growth response l polycystic ovary syndrome ovulatory disfunction 
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