《Current Medical Science》

作品数：998被引量：2830H指数：19
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《Current Medical Science》
主办单位：Huazhong University of Science and Technology （HUST）
最新期次：2024年5期更多>>
发文主题：INFLAMMATIONPATIENTSPROGNOSISAPOPTOSISPATHWAY更多>>
发文领域：医药卫生经济管理自动化与计算机技术文化科学更多>>
发文基金：国家自然科学基金湖北省自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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Naringin and Naringenin:Potential Multi-Target Agents for Alzheimer’s Disease
《Current Medical Science》2024年第5期867-882,共16页Jing LU Jie CHEN Shu-yue LI Guang-jie PAN Yi OU Li-fu YUAN Jian-ping JIANG Ling-hui ZENG Jie ZHAO 
supported by the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.TGD23C050001);by National Natural Science Foundation of China(No.82074186).
Alzheimer’s disease(AD)is one of the most common forms of neurodegenerative dementia.The etiology of AD is multifactorial,and its complex pathophysiology involves tau and amyloid-βdeposition,increased oxidative stre...
关键词：Alzheimer’s disease NARINGIN NARINGENIN multitarget 
Research Advancements in the Interplay between T3 and Macrophages
《Current Medical Science》2024年第5期883-889,共7页Liu YANG Meng-fei FU Han-yu WANG Hui SUN 
3,3′,5-Triiodo-L-thyronine(T3)is a key endocrine hormone in the human body that plays crucial roles in growth,development,metabolism,and immune function.Macrophages,the key regulatory cells within the immune system,e...
关键词：3 3′ 5-triiodo-L-thyronine MACROPHAGES inflammatory response IMMUNITY regulatory mechanism 
Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
《Current Medical Science》2024年第5期890-901,共12页Bi-qiong ZHANG Feng-qing WANG Jie YIN Xiao-tan YU Zheng-xi HU Liang-hu GU Qing-yi TONG Yong-hui ZHANG 
financially supported by the National Natural Science Foundation of China(No.81903461);the Natural Science Foundation of Hubei Province(No.ZRMS2023000340).
Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult...
关键词：pyrrolidone analogs Michael acceptor DNA damage mitochondrial dysfunction APOPTOSIS 
Protective Effects of Berberine on Nonalcoholic Fatty Liver Disease in db/db Mice via AMPK/SIRT1 Pathway Activation
《Current Medical Science》2024年第5期902-911,共10页Cheng CHEN Xiao-cui LIU Bin DENG 
supported by grants from the National Natural Science Foundation of China(No.81803799);Hubei Province Natural Science Foundation of China(No.2022CFB092).
Objective Berberine(BBR)has emerged as a promising therapeutic agent for nonalcoholic fatty liver disease(NAFLD).This study aims to elucidate the underlying molecular mechanisms.Methods In this study,db/db mice were c...
关键词：nonalcoholic fatty liver disease BERBERINE INFLAMMATION oxidative stress apoptosis 
Risk Factors for Mortality in Critically Ill Patients with Coagulation Abnormalities:A Retrospective Cohort Study
《Current Medical Science》2024年第5期912-922,共11页Qiu-yu GUO Jun PENG Ti-chao SHAN Miao XU 
supported by grants from National Key R&D Program of China(No.2023YFC2507800);ECCM Program of Clinical Research Centre of Shandong University(No.2021SDUCRCB008);Young Taishan Scholar Foundation of Shandong Province(No.tsqn201812133);the Fundamental Research Funds of Shandong University(No.2020QNQT001);National Natural Science Foundation of China(No.81900124).
Objective Coagulation abnormalities are common and prognostically significant in intensive care units(ICUs)and are associated with increased mortality.This study aimed to explore the association between the levels of ...
关键词：blood coagulation markers MORTALITY risk factors disseminated intravascular coagulation intensive care unit 
Clinical Value of ABCB1 and PAI-1 Gene Polymorphisms in Predicting Glucocorticoid-induced Adverse Reactions in Nephrotic Syndrome Patients
《Current Medical Science》2024年第5期923-931,共9页Ya-ling ZHAI Shuai-gang SUN Wen-hui ZHANG Hui-juan TIAN Zhan-zheng ZHAO 
supported by the General Project of Henan Natural Science Foundation(No.232300420034);the National Natural Science Foundation of China for the Youth(No.81600555);the General Project of China Postdoctoral Science Foundation(No.2018M640684)。
Objective Glucocorticoid(GC)-induced adverse reactions(ARs)have been extensively studied due to their potential impact on patients’health.This study aimed to examine the potential correlation between two polymorphism...
关键词：adenosine triphosphate-binding cassette B1 nephrotic syndrome plasminogen activator inhibitor-1 steroid-associated avascular necrosis of the femoral head steroid diabetes 
Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs
《Current Medical Science》2024年第5期932-946,共15页Xue LI Chao YAO Dong-mei LAN Yan WANG Sheng-cai QI 
funded by the National Key Clinical Program on Orthodontics,the Nature Science Foundation of Shanghai(No.20ZR1443100 and No.21140904500);Shanghai Municipal Health Commission(No.202140504).
Objective Porphyromonas gingivalis(P.gingivalis)is a gram-negative bacterium found in the human oral cavity and is a recognized pathogenic bacterium associated with chronic periodontitis and systemic diseases,includin...
关键词：Porphyromonas gingivalis chronic kidney disease glomerular mesangial cells MACROPHAGES NF-κB/NLRP3 pathway ferroptosis 
Diagnostic Value of Targeted Next-generation Sequencing in Pulmonary Mycobacterial Infections
《Current Medical Science》2024年第5期947-953,共7页Yu TAO Zi-wei ZHOU Yi-fei DUAN Jian-miao WANG 
Objective This study aimed to explore the diagnostic value of novel technique-targeted next-generation sequencing(tNGS)of bronchoalveolar lavage fluid(BALF)in pulmonary mycobacterial infections.Methods This retrospect...
关键词：targeted next-generation sequencing Mycobacterium tuberculosis nontuberculous mycobacteria bronchoalveolar lavage fluid 
Androgen Receptor Promotes Lung Cancer Metastasis by Modifying the miR23a-3p/EPHB2 Pathway
《Current Medical Science》2024年第5期954-963,共10页Yan YANG Jing-wen HUANG Wei-wei YU 
supported by the Zhongnanshan Medical Foundation of Guangdong Province(No.ZNSXS-20220072).
Objective This study aimed to investigate the reasons behind the lower survival rates in male lung cancer patients than in female lung cancer patients.Methods Through various techniques,such as Argonaute immunoprecipi...
关键词：androgen receptor lung cancer metastasis miRNA-23a-3p EPHB2 
Suppression of miR-17 Alleviates Acute Respiratory Distress-associated Lung Fibrosis by Regulating Mfn2
《Current Medical Science》2024年第5期964-970,共7页Mei-xia XU Tao XU Ning AN 
supported by grants from the Natural Science Foundation of Hubei Province(No.2022CFB423,2023AFB1055);Hubei Province Health and Family Planning Scientific Research Project(No.WJ2023M030).
Objective Acute respiratory distress syndrome(ARDS)patients currently have relatively high mortality,which is associated with early lung fibrosis.This study aimed to investigate whether miR-17 suppression could allevi...
关键词：miR-17 MFN2 acute respiratory distress syndrome pulmonary fibrosis MITOCHONDRIA 
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