云南高校图书馆联盟文献共享服务平台- Synthetic and Systems Biotechnology

《Synthetic and Systems Biotechnology》: 作品数：507被引量：666H指数：10; 导出分析报告; 主办单位：中国科技出版传媒股份有限公司; 最新期次：2024年4期更多>>; 发文主题：METABOLIC_ENGINEERINGBIOSYNTHESISENGINEERINGSYNTHETICSACCHAROMYCES_CEREVISIAE更多>>; 发文领域：生物学理学医药卫生经济管理更多>>; 发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金高等学校学科创新引智计划更多>>

A highly efficient method for genomic deletion across diverse lengths in thermophilic Parageobacillus thermoglucosidasius: 《Synthetic and Systems Biotechnology》2024年第4期658-666,共9页Zhiheng Yang Bixiao Li Ruihong Bu Zhengduo Wang Zhenguo Xin Zilong Li Lixin Zhang Weishan Wang; supported by the National Key Research and Development Program of China(2020YFA0907800);the National Natural Science Foundation of China(32170095 and 32100066);the Youth Innovation Promotion Association CAS(Y202027)to W.W.; Parageobacillus thermoglucosidasius is emerging as a highly promising thermophilic organism for metabolic engineering.The utilization of CRISPR-Cas technologies has facilitated programmable genetic manipulation in P.t...; 关键词：Type I CRISPR system Thermostable NHEJ enzymes THERMOPHILE Long-range genomic deletions

Development of multi-epitope mRNA vaccine against Clostridioides difficile using reverse vaccinology and immunoinformatics approaches被引量：1: 《Synthetic and Systems Biotechnology》2024年第4期667-683,共17页Caixia Tan Yuanyuan xiao Ting Liu Siyao Chen Juan Zhou Sisi Zhang Yiran Hu Anhua Wu Chunhui Li; upported by the National Key Research and Development Program of China[No.2022YFC2009801,No.2022YFC2009805];the Natural Science Foundation of Hunan Province[No.2021JJ31071];the Project program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital)[No.2021KFJJ05];Health Development Research Center of the National Health Commission,"Evidence-based Evaluation and Demonstration Base Construction Project of Infection Control Measures in Healthcare Institutions"[No.CNHDRC-KJ-L-2020-53-04375];Scientific and technological personnel lifting Project in Hunan Province[No.2023 TJ-Z11].; Clostridioides difficile(C.difficile),as the major pathogen of diarrhea in healthcare settings,has become increasingly prevalent within community populations,resulting in significant morbidity and mortality.However,th...; 关键词：Clotridioides difficile(C.difficile) mRNA vaccine IMMUNOINFORMATICS Reverse vaccinology(RV) Molecular docking Molecular dynamics(MD)simulation

New N-acylated aminoalkanoic acids from tea roots derived biocontrol agent Clonostachys rosea 15020: 《Synthetic and Systems Biotechnology》2024年第4期684-693,共10页Jiaming Yu Yue Zhang Li Zhang Jie Shi Kun Wang Weize Yuan Zexu Lin Shangqian Ning Bohao Wang Xinye Wang Yuyang Qiu Tom Hsiang Lixin Zhang Xueting Liu Guoliang Zhu; support from the National Key Research and Development Program of China(2019YFA0906200);the National Natural Science Foundation of China(21977029,81903529,21877038,31720103901,and 81573341);the Open Project Funding of the State Key Laboratory of Bioreactor Engineering,the 111 Project(B18022).; Four new N-acylated aminoalkanoic acids,namely clonoroseins E−H(1−4),together with three previously identified analogs,clonoroseins A,B,and D(5−7),were identified from the endophytic fungus Clonostachys rosea strain 1...; 关键词：Endophytic fungi N-acylated aminoalkanoic acid FBMN Adenylate-forming enzyme

Biochemical synthesis of taxanes from mevalonate: 《Synthetic and Systems Biotechnology》2024年第4期694-700,共7页Jing Li Xiaonan Liu Xiaoxi Zhu Jiayu Liu Lei Zhang Nida Ahmed Jian Qi Bihuan Chen Daliang Tang Jinsheng Yu Zhijin Fan Huifeng Jiang; supported in part by the National Natural Science Foundation of China(32371499,31901026 and 32172443),China Postdoctoral Science Foundation(2019M661032);National Key R&D Program of China(2020YFA0908000 and 2022YFD1700400);the Frontiers Science Center for New Organic Matter,Nankai University(63181206);he Tianjin Development Program for Innovation and Entrepreneurship(2019-06).; Taxanes are kinds of diterpenoids with important bioactivities,such as paclitaxel(taxol®)is an excellent natural broad-spectrum anticancer drug.Attempts to biosynthesize taxanes have made with limited success,mainly d...; 关键词：Biochemical synthesis TAXANES PACLITAXEL Modular synthesis

Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products: 《Synthetic and Systems Biotechnology》2024年第4期701-712,共12页Kemeng Li Zhengyan Guo Liping Bai; supported by grants from National Key Research and Development Program of China(2018YFA0902000);National Natural Science Foundation of China(82173721);CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-029).; Digitoxose,a significant 2,6-dideoxyhexose found in nature,exists in many small-molecule natural products.These digitoxose-containing natural products can be divided into steroids,macrolides,macrolactams,anthracycline...; 关键词：Digitoxose BIOSYNTHESIS Small-molecule natural products Digitoxose glycosylation

Combinatorial metabolic engineering of Escherichia coli for de novo production of structurally defined and homogeneous Amino oligosaccharides: 《Synthetic and Systems Biotechnology》2024年第4期713-722,共10页Jinqi Shi Chen Deng Chunyue Zhang Shu Quan Liqiang Fan Liming Zhao; supported by the Young Scientists Fund of the National Natural Science Foundation of China(32301214);Shanghai Post-doctoral Excellence Program(2022148);the 111 Project(B18022).; Amino oligosaccharides(AOs)possess various biological activities and are valuable in the pharmaceutical,food industries,and agriculture.However,the industrial manufacturing of AOs has not been realized yet,despite rep...; 关键词：Amino oligosaccharides Chitin oligosaccharides Metabolic engineering Fed-batch cultivation bioproduction

Overexpression of arginase gene CAR1 renders yeast Saccharomyces cerevisiae acetic acid tolerance: 《Synthetic and Systems Biotechnology》2024年第4期723-732,共10页Liang Xiong Ya-Ting Wang Ming-Hai Zhou Hiroshi Takagi Jiufu Qin Xin-Qing Zhao; supported financially by National Key Research and Development Program(No.2022YFE0108500);National Natural Science Foundation of China(No.21978168)to X.-Q.Z;JFQ appreciates the grant from Sichuan Natural Science Foundation(No.2023NSFSC0132).; Acetic acid is a common inhibitor present in lignocellulose hydrolysate,which inhibits the ethanol production by yeast strains.Therefore,the cellulosic ethanol industry requires yeast strains that can tolerate acetic ...; 关键词：Saccharomyces cerevisiae ARGINASE CAR1 Acetic acid tolerance Amino acid metabolism Ethanol production

Identification of a human type XVII collagen fragment with high capacity for maintaining skin health: 《Synthetic and Systems Biotechnology》2024年第4期733-741,共9页Xinglong Wang Shuyao Yu Ruoxi Sun Kangjie Xu Kun Wang Ruiyan Wang Junli Zhang Wenwen Tao Shangyang Yu Kai Linghu Xinyi Zhao Jingwen Zhou; funded by the Natural Science Foundation of Jiangsu Province(BK20202002);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(Grant No.SN-ZJU-SIAS-0013);China Postdoctoral Science Foundation(2023M741403);Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB037);the National First-class Discipline Program of Light Industry Technology and Engineering(QGJC20230102).; Collagen XVII(COL17)is a transmembrane protein that mediates skin homeostasis.Due to expression of full length collagen was hard to achieve in microorganisms,arising the needs for selection of collagen fragments with ...; 关键词：Type XVII collagen Hair follicle stem cell differentiation Higher-order assembly Collagen recombinant expression

Transportation engineering for enhanced production of plant natural products in microbial cell factories: 《Synthetic and Systems Biotechnology》2024年第4期742-751,共10页Yimeng Zuo Minghui Zhao Yuanwei Gou Lei Huang Zhinan Xu Jiazhang Lian; supported by Fundamental Research Funds for the Zhejiang Provincial Universities(226-2023-00015);National Natural Science Foundation of China(22278361,32200052,and 32300053);China Postdoctoral Science Foundation(2023M733096);National Key Research and Development Program of China(2018YFA0901800 and 2021YFC2103200).; Plant natural products(PNPs)exhibit a wide range of biological activities and have essential applications in various fields such as medicine,agriculture,and flavors.Given their natural limitations,the production of hi...; 关键词：Plant natural products Transportation engineering Transporters Microbial cell factories

Engineering Corynebacterium glutamicum for the efficient production of 3-hydroxypropionic acid from glucose via theβ-alanine pathway: 《Synthetic and Systems Biotechnology》2024年第4期752-758,共7页Xiaodi Wang Junyuan Hou Jieyao Cui Zhiwen Wang Tao Chen; supported by the National Key Research and Development Program of China(2021YFC2100700);the National Natural Science Foundation of China(NSFC-21776208).; 3-Hydroxypropionic Acid(3-HP)is recognized as a high value-added chemical with a broad range of applications.Among the various biosynthetic pathways for 3-HP production,theβ-alanine pathway is particularly noteworthy...; 关键词：3-Hydroxypropionic acid β-Alanine pathway Corynebacterium glutamicum Metabolic engineering

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