《BioDesign Research》

作品数：71被引量：34H指数：3
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《BioDesign Research》
主办单位：南京农业大学
最新期次：2024年1期更多>>
发文主题：PLANTSYNTHETICENGINEERINGEDITINGPRECISE更多>>
发文领域：生物学理学医药卫生自动化与计算机技术更多>>
发文基金：国家自然科学基金上海市自然科学基金国家重点基础研究发展计划The Royal Society更多>>
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Advances in the Application of Single-Cell Transcriptomics in Plant Systems and Synthetic Biology
《BioDesign Research》2024年第1期51-67,共17页Md Torikul Islam Yang Liu Md Mahmudul Hassan Paul E.Abraham Jean Merlet Alice Townsend Daniel Jacobson C.Robin Buell Gerald A.Tuskan Xiaohan Yang 
supported by the Center for Bioenergy Innovation(CBI),which is a U.S.Department of Energy(DOE)Bioenergy Research Center supported by the Office of Biological and Environmental Research in the DOE Office of Science,and the DOE Genomic Science Program,as part of the Secure Ecosystem Engineering and Design Scientific(SEED)Focus Area.Oak Ridge National Laboratory is man-aged by UT-Battelle,LLC for the U.S.DOE under Contract Number DE-AC05-00OR22725;This material is based on work supported by the U.S.Department of Energy,Ofice of Science,Biological and Environmental Research Program under Award Number DE-SC0023338 to CRB.
Plants are complex systems hierarchically organized and composed of various cell types.To understand the molecular underpinnings of complex plant systems,single-cell RNA sequencing(scRNA-seq)has emerged as a powerful ...
关键词：application BIOLOGY systems PLANT ADVANCES SINGLE-CELL SYNTHETIC TRANSCRIPTOMICS 
Harnessing a T1 Phage-Derived Spanin for Developing Phage-Based Antimicrobial Development被引量：1
《BioDesign Research》2024年第1期28-38,共11页Wakana Yamashita Shinjiro Ojima Azumi Tamura Aa Haeruman Azam Kohei Kondo Zhang Yuancheng Longzhu Cui Masaki Shintani Masato Suzuki Yoshimasa Takahashi Koichi Watashi Satoshi Tsuneda Kotaro Kiga 
supported by the Japan Agency for Medical Research and Development under grant numbers JP23wm0325065,JP22fk0108532,JP21fk0108496,and JP21 wm0325022 to K.K.;grant number JP21gm1610002 to L.C.and K.K.;JSPS KAKENHI grants numbers 21H02110 and 21K19666 to K.K.
The global increase in the prevalence of drug-resistant bacteria has necessitated the development of alternative treatments that do not rely on conventional antimicrobial agents.Using bacteriophage-derived lytic enzym...
关键词：DEVELOPMENT ANTIMICROBIAL DEVELOPING harnessing phage-based phage-derived spanin 
Microbial Upcycling of Depolymerized Lignin into Value-Added Chemicals
《BioDesign Research》2024年第1期39-50,共12页Yang Zhang Cheng Cheng Bixia Fu Teng Long Ning He Jianqiang Fan Zheyong Xue Anqi Chen Jifeng Yuan 
supported by the National Key Research and Development Program of China(2022YFC2104600);the National Natural Science Foundation of China(nos.32270087,32241040,and 31970314);the Natural Science Foundation of Fujian Province of China(no.2020J05011);Guangdong Basic and Applied Basic Research Foundation(no.2021A1515110340);Xiamen University(no.0660X2510200);the Fundamental Research Funds for the Central Universities(no.20720220086),and ZhenSheng Biotech.
Lignin is one of the most widespread organic compounds found on earth,boasting a wealth of aromatic molecules.The use of lignin feedstock for biochemical productions is of great importance for achieving"carbon neutral...
关键词：CHEMICALS depolymerized into LIGNIN MICROBIAL upcycling VALUE-ADDED 
Multidimensional Optimization of Saccharomyces cerevisiae for Carotenoid Overproduction被引量：1
《BioDesign Research》2024年第1期20-27,共8页Jian Fan Yang Zhang Wenhao Li Zhizhen Li Danli Zhang Qiwen Mo Mingfeng Cao Jifeng Yuan 
support from the National Natural Science Foundation of China(32270087);the Natural Science Foundation of Fujian Province of China(2020J05011);Guangdong Basic and Applied Basic Research Foundation(2021A1515110340);Xiamen University(0660X2510200);Daan Gene(20223160A0063),and ZhenSheng Biotech.
Microbial synthesis of carotenoids is a highly desirable alternative to plant extraction and chemical synthesis.In this study,we investigated multidimensional strategies to improve the carotenoid synthesis in the indu...
关键词：OPTIMIZATION dimension siona multi CAROTENOID CEREVISIAE OVERPRODUCTION SACCHAROMYCES 
A MoClo-Compatible Toolbox of ECF Sigma Factor-Based Regulatory Switches for Proteobacterial Chassis
《BioDesign Research》2024年第1期1-19,共19页Doreen Meier Christian Rauch Marcel Wagner Paul Klemm Patrick Blumenkamp Raphael Müller Eric Ellenberger Kinnari M.Karia Stefano Vecchione Javier Serrania Marcus Lechner Georg Fritz Alexander Goesmann Anke Becker 
supported by the ERASynBio program of the Federal Ministry of Education and Research(Germany,grant 031L0010B);the LOEWE program of the State of Hesse(Germany)through funding of the Center for Synthetic Microbiology(SYNMIKRO).
The construction of complex synthetic gene circuits with predetermined and reliable output depends on orthogonal regulatory parts that do not inadvertently interfere with the host machinery or with other circuit compo...
关键词：TOOLBOX sigma CHASSIS compatible factor-based moclo proteobacterial REGULATORY switches 
Peptide Variant Detection by a Living Yeast Biosensor via an Epitope-Selective Protease被引量：1
《BioDesign Research》2023年第1期1-11,共11页Tea Crnković Benjamin J.Bokor Mead E.Lockwood Virginia W.Cornish 
DARPA award HR0011-15-2-0032.
We previously demonstrated that we could hijack the fungal pheromone signaling pathway to provide a living yeast biosensor where peptide biomarkers were recognized by G-protein-coupled receptors and engineered to tran...
关键词：APPARENT otherwise utilizing 
Phages and Nanotechnology:New Insights against Multidrug-Resistant Bacteria
《BioDesign Research》2023年第1期12-24,共13页Marco Pardo-Freire Pilar Domingo-Calap 
project PID2020-112835RA-I00 funded by MCIN/AEI/10.13039/501100011033 to P.D.-C.P.D.-C.;Ramón y Cajal contract RYC2019-028015-I funded by MCIN/AEI/10.13039/501100011033,ESF Invest in your future.
Bacterial infections are a major threat to the human healthcare system worldwide,as antibiotics are becoming less effective due to the emergence of multidrug-resistant strains.Therefore,there is a need to explore nont...
关键词：DIAGNOSIS mostly ULTRAVIOLET 
Engineering Nitrogenases for Synthetic Nitrogen Fixation:From Pathway Engineering to Directed Evolution被引量：1
《BioDesign Research》2023年第1期25-36,共12页Emily M.Bennett James W.Murray Mark Isalan 
E.B.is supported by a BBSRC Doctoral Training Partnership Studentship(Project Reference:1949015).
Globally,agriculture depends on industrial nitrogen fertilizer to improve crop growth.Fertilizer production consumes fossil fuels and contributes to environmental nitrogen pollution.A potential solution would be to ha...
关键词：CROPS SYNTHETIC EVOLUTION 
De Novo Design and Synthesis of Polypeptide Immunomodulators for Resetting Macrophage Polarization
《BioDesign Research》2023年第1期37-48,共12页Na Kong Hongru Ma Zhongji Pu Fengju Wan Dongfang Li Lei Huang Jiazhang Lian Xingxu Huang Shengjie Ling Haoran Yu Yuan Yao 
the National Natural Science Foundation of China(nos.32071347,51973116,21935002,and 52003156);ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University(02020200-K02013008);the China Postdoctoral Science Foundation(2020M681344);joint laboratory grant from Jiangsu Wuzhong Aesthetics Biotech Co.Ltd;and the starting grant of ShanghaiTech University.Materials were tested at Analytical Instrumentation Center(#SPST-AIC10112914)and the Center for High-Resolution Electron Microscopy(CћEM),SPST,ShanghaiTech University.
Modulating the extracellular matrix microenvironment is critical for achieving the desired macrophage phenotype in immune investigations or tumor therapy.Combining de novo protein design and biosynthesis techniques,he...
关键词：MODULATOR POLARIZATION PRECISE 
qSanger:Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing
《BioDesign Research》2023年第1期49-57,共9页Satya Prakash Adrian Racovita Teresa Petrucci Roberto Galizi Alfonso Jaramillo 
the Ministerio de Ciencia e Innovacion GeneCircuits++PID2020-118436GB-I00(A.J.);BBSRC BB/P020615/1(A.J.);EU grants EVOPROG 610730 and PhotoSynH2 HORIZON-EIC-2021-PATHFINDERCHALLENGES(grant agreement 101070948)(A.J.);School of Life Sciences departmental allocation,Keele University(R.G.).
Genetic variations such as mutations and recombinations arise spontaneously in all cultured organisms.Although it is possible to identify nonneutral mutations by selection or counterselection,the identification of neu...
关键词：NEUTRAL consuming transformed 
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