OVERPRODUCTION

作品数：40被引量：185H指数：8
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相关领域：医药卫生更多>>
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相关机构：浙江省农业科学院北京理工大学更多>>
相关期刊：《World Journal of Biological Chemistry》《BioDesign Research》《中国生物学文摘》《Beijing Review》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家科技支撑计划国家高技术研究发展计划更多>>
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Multidimensional Optimization of Saccharomyces cerevisiae for Carotenoid Overproduction被引量：1
《BioDesign Research》2024年第1期20-27,共8页Jian Fan Yang Zhang Wenhao Li Zhizhen Li Danli Zhang Qiwen Mo Mingfeng Cao Jifeng Yuan 
support from the National Natural Science Foundation of China(32270087);the Natural Science Foundation of Fujian Province of China(2020J05011);Guangdong Basic and Applied Basic Research Foundation(2021A1515110340);Xiamen University(0660X2510200);Daan Gene(20223160A0063),and ZhenSheng Biotech.
Microbial synthesis of carotenoids is a highly desirable alternative to plant extraction and chemical synthesis.In this study,we investigated multidimensional strategies to improve the carotenoid synthesis in the indu...
关键词：OPTIMIZATION dimension siona multi CAROTENOID CEREVISIAE OVERPRODUCTION SACCHAROMYCES 
Coupled strategy based on regulator manipulation and medium optimization empowers the biosynthetic overproduction of lincomycin
《Synthetic and Systems Biotechnology》2024年第1期134-143,共10页Xinlu Cai Wanlian Xu Yang Zheng Sendi Wu Rundong Zhao Nian Wang Yaqian Tang Meilan Ke Qianjin Kang Linquan Bai Buchang Zhang Hang Wu 
supported in part by the Anhui Provincial Natural Science Foundation for Excellent Young Scholars(grant no.2208085Y09);the National Natural Science Foundation of China(grant no.32170073,31972930).
The biosynthesis of bioactive secondary metabolites,specifically antibiotics,is of great scientific and economic importance.The control of antibiotic production typically involves different processes and molecular mec...
关键词：STREPTOMYCES Transcription factor Genetic engineering Fermentation optimization LINCOMYCIN 
A combined strategy for the overproduction of complex ergot alkaloid agroclavine
《Synthetic and Systems Biotechnology》2022年第4期1126-1132,共7页Zhi-Pu Yu Chunyan An Yongpeng Yao Chang-Yun Wang Zhoutong Sun Chengsen Cui Ling Liu Shu-Shan Gao 
This study was supported by the National Key Research and Development Program of China(grant nos.2021YFC2100600,2019YFA0905100 and 2018YFA0901600);the National Natural Science Foundation of China(grant nos.31872614,32022002,21977113);the Youth Scientists Innovation Promotion Association of CAS(2019090)to S.S.G.,Innovative Cross Team project of Chinese Academy of Sciences,CAS(grant no.JCTD-2019-06);Shandong Provincial Natural Science Foundation(Major Basic Research Projects)(grant no.ZR2019ZD18).
Microbial cell factories(MCFs)and cell-free systems(CFSs)are generally considered as two unrelated approaches for the biosynthesis of biomolecules.In the current study,two systems were combined together for the overpr...
关键词：Microbial cell factories Cell-free systems OVERPRODUCTION Agroclavine Ergot alkaloids 
Overproduction of OsRACK1A,an effector-targeted scaffold protein promoting OsRBOHB-mediated ROS production,confers rice floral resistance to false smut disease without yield penalty被引量：9
《Molecular Plant》2022年第11期1790-1806,共17页Guo-Bang Li Jia-Xue He Jin-Long Wu He Wang Xin Zhang Jie Liu Xiao-Hong Hu Yong Zhu Shuai Shen Yi-Fei Bai Zong-Lin Yao Xin-Xian Liu Jing-Hao Zhao De-Qiang Li Yan Li Fu Huang Yan-Yan Huang Zhi-Xue Zhao Ji-Wei Zhang Shi-Xin Zhou Yun-Peng Ji Mei Pu Peng Qin Shigui Li Xuewei Chen Jing Wang Min He Weitao Li Xian-Jun Wu Zheng-Jun Xu Wen-Ming Wang Jing Fan 
National Natural Science Foundation of China,China(32072503 to J.F.,U19A2033 to W.-M.W.,and 32121003 to X.C.);Sichuan Youth Science and Technology Innovation Research Team(2022JDTD0023 to J.F.);Sichuan Applied Fundamental Research Foundation(2020JDJQ0040 to J.W.).
Grain formation is fundamental for crop yield but is vulnerable to abiotic and biotic stresses.Rice grain production is threatened by the false smut fungus Ustilaginoidea virens,which specifically infects rice floral ...
关键词：rice flower false smut fungal effector scaffold protein reactive oxygen species disease resistance 
Biofilm-overproducing Bacillus subtilis B12ΔYwcc decreases Cd uptake in Chinese cabbage through increasing Cd-immobilizing related gene abundance and root surface colonization被引量：1
《Journal of Environmental Sciences》2022年第10期84-93,共10页Yanyan Ge Zhanbiao Ge Jinwei Zheng Xiafang Sheng Linyan He 
supported by the National Natural Science Foundation of China (No. 41977199);the Social Development Program of Jiangsu Province (No. BE2016744)。
Biofilm-producing bacteria can decrease Cd uptake in vegetables, but mechanisms underlying this effect are poorly characterized. In this study, two mutant strains B12ΔYwcc and B12ΔSlr R were constructed from a biofi...
关键词：Biofilm-producing Bacillus subtilis Mutant strain with biofilm overproduction Cd uptake in vegetable Cd-stabilizing related genes Bacterial colonization and biofilm formation 
Transcriptome-guided identification of a four-component system, SbrH1-R, that modulates milbemycin biosynthesis by influencing gene cluster expression, precursor supply, and antibiotic efflux被引量：1
《Synthetic and Systems Biotechnology》2022年第2期705-717,共13页Lan Ye Yanyan Zhang Shanshan Li Hairong He Guomin Ai Xiangjing Wang Wensheng Xiang 
This work was financially supported by National Natural Science Foundation of China(31872936,31972291,and 31972348).
Streptomyces can produce numerous antibiotics and many other bioactive compounds.Recently,the molecular mechanisms of transcriptional regulators in control of antibiotic production by influencing the expression of bio...
关键词：Milbemycins Streptomyces bingchenggensis SbrH1-R Precursor supply Milbemycin exporter OVERPRODUCTION 
Light-activated nitric-oxide overproduction theranostic nanoplatform based on long-circulating biomimetic nanoerythrocyte for enhanced cancer gas therapy
《Science China Chemistry》2021年第10期1796-1810,共15页Cheng-Guang Wu Jing-Lan Liang Xiang Wang Xiaoyan Zhou Xiang Cai Jun Xu Meng Wang Wen-Bo Wang Dong Ma Wei Xue 
the National Natural Science Foundation of China(31870943);the Thousands of Doctors(Postdoctoral)Program of Guangdong Academy of Sciences(2019GDASYL-0103015);the Basic and Applied Basic Research Fund of Guangdong Province(2019A1515110663);the Traditional Chinese Medicine Bureau of Guangdong Province(20201109)。
The limited intratumoral perfusion of nitric oxide(NO)-carrying nanoparticles into solid tumors caused by the inherent biological barriers in vivo greatly attenuates their generated efficacy. Herein, through entrappin...
关键词：nitric oxide biomimetic nanoerythrocyte PTT/NO synergistic therapy bimodal imaging 
Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction被引量：2
《Synthetic and Systems Biotechnology》2020年第2期37-48,共12页Ruida Wang Fanjing Kong Haizhen Wu Bingbing Hou Yajing Kang Yuan Cao Shiwei Duan Jiang Ye Huizhan Zhang 
This study was supported by the National Natural Science Foundation of China(NSFC)(31900059);the China Postdoctoral Science Foundation(2019M650079);the Research Program of State Key Laboratory of Bioreactor Engineering.We thank Dr.Weihong Jiang(Institute of Plant Physiology and Ecology,Chinese Academy of Sciences)for kindly providing the plasmid pKCcas9dO.
The lincosamide family antibiotic lincomycin is a widely used antibacterial pharmaceutical generated by Streptomyces lincolnensis,and the high-yield strain B48 produces 2.5 g/L lincomycin,approximately 30-fold as the ...
关键词：LINCOMYCIN Comparative genomics REGULATION OVERPRODUCTION 
Coordinated regulation for nature products discovery and overproduction in Streptomyces被引量：2
《Synthetic and Systems Biotechnology》2020年第2期49-58,共10页Qun Zhou Shuqing Ning Yunzi Luo 
This work was supported by the National Key R&D Program of China(2018YFA0903300);the Natural Science Foundation of Tianjin Province(19JCYBJC24200);the National Natural Science Foundation of China(81502966).
Streptomyces is an important treasure trove for natural products discovery.In recent years,many scientists focused on the genetic modification and metabolic regulation of Streptomyces to obtain diverse bioactive compo...
关键词：Gene expression regulation Natural products STREPTOMYCES Biosynthetic gene clusters 
The X-factor: Enhanced β-oxidation on intracellular triacylglycerols enabling overproduction of polyketide drug-like molecules in microorganisms被引量：1
《Synthetic and Systems Biotechnology》2020年第1期19-20,共2页Shan Wang Hai Deng 
This work was supported by Biotechnology and Biological Sciences Research Council(BBSRC)award(BB/P00380X/1)to H.D.
Natural products have been an unprecedented starting point for drug and agrochemical discovery.They represent the only validated source of chemical diversity capable of delivering a sustainable pipeline for novel drug...
关键词：drugs STARTING approved 
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