TANSHINONES

作品数：19被引量：68H指数：5
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相关领域：医药卫生农业科学更多>>
相关作者：秦路平韩婷明乾良更多>>
相关机构：第二军医大学更多>>
相关期刊：《Chinese Herbal Medicines》《Journal of Rare Earths》《Medicinal Plant》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金国家教育部博士点基金中国博士后科学基金国家高技术研究发展计划更多>>
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The ABC transporter SmABCG1 mediates tanshinones export from the peridermic cells of Salvia miltiorrhiza root
《Journal of Integrative Plant Biology》2025年第1期135-149,共15页Yajing Li Junfeng Chen Jingyu Zhi Doudou Huang Yuchen Zhang Lei Zhang Xinyi Duan Pan Zhang Shi Qiu Jiaran Geng Jingxian Feng Ke Zhang Xu Yang Shouhong Gao Wenwen Xia Zheng Zhou Yuqi Qiao Bo Li Qing Li Tingzhao Li Wansheng Chen Ying Xiao 
financially supported by the National Key Research and Development Program of China(2022YFC3501700);the National Natural Science Foundation of China(82304662,82374159,32070327,32170402);the National Key Research and Development Program of China(2023YFC3504800);Chenguang project of Shanghai(23CGA52);Science and Technology Development Program of Shanghai University of Traditional Chinese Medicine(23KFL051);Shanghai Municipal Science and Technology Commission(23XD1423500)。
Plants have mechanisms to transport secondary metabolites from where they are biosynthesized to the sites where they function,or to sites such as the vacuole for detoxification.However,current research has mainly focu...
关键词：ATP-binding cassette transporter biosynthesis gene cluster CYTOTOXICITY EXPORT peridermic cells TANSHINONE 
Engineering the microenvironment of P450s to enhance the production of diterpenoids in Saccharomyces cerevisiae被引量：1
《Acta Pharmaceutica Sinica B》2024年第10期4608-4618,共11页Yatian Cheng Linglong Luo Hao Tang Jian Wang Li Ren Guanghong Cui Yujun Zhao Jinfu Tang Ping Su Yanan Wang Yating Hu Ying Ma Juan Guo Luqi Huang 
supported by the National Key R&D Program of China(2020YFA0908000);Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023D002,CI2023E002,CI2021A04110,CI2021B014);the National Natural Science Foundation of China(81822046);Key project at central government level:The ability to establish sustainable use of valuable Chinese medicine resources(2060302).
Cytochrome P450 enzymes play a crucial role as catalysts in the biosynthesis of numerous plant natural products(PNPs).Enhancing the catalytic activity of P450s in host microorganisms is essential for the efficient pro...
关键词：Saccharomyces cerevisiae Metabolic engineering P450s TANSHINONES 11 20-Dihydroxyferruginol 
Chromosome-level genome assembly of Salvia miltiorrhiza with orange roots uncovers the role of Sm2OGD3 in catalyzing 15,16-dehydrogenation of tanshinones被引量：3
《Horticulture Research》2023年第6期30-42,共13页Xian Pan Yujie Chang Caili Li Xiaoxiao Qiu Xinyun Cui Fanqi Meng Sixuan Zhang Xian’en Li Shanfa Lu 
We are thankful for financial support from the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-029);the National Natural Science Foundation of China(81773836).
Salvia miltiorrhiza is well known for its clinical practice in treating heart and cardiovascular diseases.Its roots,used for traditional Chinese medicine materials,are usually brick-red due to accumulation of red pigm...
关键词：OGD ROOTS ORANGE 
The SmMYB36-SmERF6/SmERF115 module regulates the biosynthesis of tanshinones and phenolic acids in salvia miltiorrhiza hairy roots被引量：4
《Horticulture Research》2023年第1期160-171,共12页Qi Li Xin Fang Ying Zhao Ruizhi Cao Juane Dong Pengda Ma 
This work was supported by the National Natural Science Foundation of China(Project No.32270278).
Tanshinone and phenolic acids are the most important active substances of Salvia miltiorrhiza,and the insight into their transcriptional regulatory mechanisms is an essential process to increase their content in vivo....
关键词：PHENOLIC ROOTS SYNTHESIS 
Development and structure-activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors
《Natural Products and Bioprospecting》2022年第1期573-585,共13页Xu Deng Su-Ling Huang Jian Ren Zheng-Hong Pan Yu Shen Hao-Feng Zhou Zhi-Li Zuo Ying Leng Qin-Shi Zhao 
the National Natural Science Foundation of China (No.U1502223);Hunan Provincial Key Research and Development Project (Grant No.2021WK2005 to X.Deng);Natural Science Foundation of Hunan Province (Grant No.2021JJ30894 to X.Deng);the open fund of State Key Laboratory of Phytochemistry and Plant Resource in West China (Grant No.P2020-KF03).
11β-Hydroxysteroid dehydrogenase 1(11β-HSD1)represents a promising drug target for metabolic syndrome,includ-ing obesity and type 2 diabetes.Our initial screen of a collection of natural products from Danshen led to...
关键词：Metabolic syndrome TANSHINONES Selective 11β-HSD1 inhibitors Structure-activity relationships 
Inhibitory Effect of Tanshinones on TNF-α-induced Inflammation in Human Aortic Endothelial Cells被引量：1
《Medicinal Plant》2018年第3期25-30,共6页Ziru ZHANG Mingyi MA Longru SUN 
Supported by the National Natural Science Foundation of China(81274031)
[Objectives] To study the anti-inflammatory activity and mechanism of tanshinone I,cryptotanshinone and 15,16-dihydrotanshinone I on HAECs induced by TNF-α. [Methods]Vitamin E was used as a positive control and TNF-...
关键词：TANSHINONES HAECs Anti-inflammatory effects NF-ΚB 
Preparation and characterisation of solid dispersions of tanshinone ⅡA, cryptotanshinone and total tanshinones被引量：2
《Asian Journal of Pharmaceutical Sciences》2017年第1期85-97,共13页Xifeng Zhai Chunguang Li George Binh Lenon Charlie C.L.Xue Weize Li 
Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge.Tanshinone ⅡA and cryptotanshinone are the major components in total tanshinones.However, the bioavailability of both compou...
关键词：CRYPTOTANSHINONE TANSHINONE ⅡA TOTAL TANSHINONES Solid DISPERSION DISSOLUTION rate 
Study on Determination of Tanshinones in Compound Danshen Tablets
《Agricultural Biotechnology》2017年第1期58-60,共3页Siyong HUANG Xianping JIN 
[ Objective ] This study was conducted to improve quality standard of Compound Danshen tablets. [ Method] Tanshinones in Compound Danshen tab- lets were determined by HPLC method. [ Result] A good linear relationship ...
关键词：Compound Danshen Tablets TANSHINONES Content Determination HPLC 
Diterpenoid Tanshinones,the extract from Danshen(Radix Salviae Miltiorrhizae)induced apoptosis in nine human cancer cell lines被引量：6
《Journal of Traditional Chinese Medicine》2016年第4期514-521,共8页Shen Li Lou Zhaohuan Zhang Guangshun Xu Guanhua Zhang Guangji 
Supported by Key Projects of Zhejiang Province Science and Technology(Arsenic Trioxide Injection Associate with Tanshinone Treat the Hepatocarcinoma of Qi-Stagnancy and Blood Stasis,No.2012C13017-1);the Specialized Research Foundation for the Doctoral Program of Higher Education of China(the Mechanism of Jak-STAT3 Signaling Transduction in Anti-Hepatocarcinoma Associated with Arsenic Trioxide and Cryptotanshinone,No.20123322110001)
OBJECTIVE:To identify the active anti-tumor constituents in the extract from Danshen(Radix Salviae Miltiorrhizae) and investigate the mechanisms underlying the actions.METHODS:First,we introduced a two-step counter-cu...
关键词：TANSHINONE Salviae Miltiorrhiza Antineoplastic agents Apoptosis Cell line tumor 
Tanshinones suppress non-small cell lung cancer through up-regulating miR-137被引量：1
《Acta Biochimica et Biophysica Sinica》2016年第8期768-770,共3页Bingjie Zhang Zhongliang Ma Xue Li Caiyan Zhang Yang Shao Zhenguo Liu Yanli Li Youxin Jin 
This work was supported in part by the grants from the National Natural Science Foundation of China （Nos. 31170750 and 31100570）.
Great progress has been made in the treatment of lung cancer, not- ably a diversification in therapeutic drugs including immunother- apies such as those based on PD-1. Among these, there are many anti-disease molecule...
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