DYSREGULATION

作品数：170被引量：528H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：杨燕青李亮廉哲雄姚远王菲菲更多>>
相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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Transcriptome dysregulation in hyper-progressive disease samples with immune checkpoint blockade
《Chinese Medical Journal》2023年第24期3019-3021,共3页Dan Xue Tengteng Zhu Hongguang Lin Peilin Guo Mengling Li Mei’e Yu Fan Yang Sheng Yang Xiangqi Chen 
supported by the Joint Funds for the Innovation of Science and Technology,Fujian Province,China(Nos.2016Y9028,2019Y9055 and 2020Y9090);Fujian provincial health technology project(No.2020CXB016);the Natural Science Foundation of Fujian Province(No.2021J01772)
To the Editor:Tumor immunotherapy has made rapid progress in recent years.However,immune checkpoint blockade(ICB)therapy may cause clinical symptoms of hyper-progressive disease(HPD),especially for patients with alter...
关键词：alterations clinical patients 
Copper homeostasis dysregulation promoting cell damage and the association with liver diseases被引量：4
《Chinese Medical Journal》2023年第14期1653-1662,共10页Tao Liu Yali Liu Feiyu Zhang Yanhang Gao 
sponsored by the National Natural Science Foundation of China(Nos.81972265,82170602);the National Natural Science Foundation of Jilin Province(No.20200201324JC);the Project for Middle-aged and Young Excellent Technological Innovation Talents of Jilin Province(No.20220508079RC);the Project for Health Talents of Jilin Province(No.JLSWSRCZX 2021-079).
Copper plays an important role in many metabolic activities in the human body.Copper level in the human body is in a state of dynamic equilibrium.Recent research on copper metabolism has revealed that copper dyshomeos...
关键词：COPPER Liver disease Cell death Cuproptosis 
Deficiency of mitochondrial aldehyde dehydrogenase increases type 2 diabetes risk in males via autophagy dysregulation
《Chinese Medical Journal》2021年第18期2246-2248,共3页Xiang-Wei Liu Lin Jiang Peng Wang Xiao-Lei Sun Xin Ma Hong Zhu Zhen Dong Cheng Shen San-Li Qian Bing-Yu Li Zhen-Sheng Xu Ai-Jun Sun Jun-Bo Ge 
supported by grants from the National Natural Science Foundation of China(No.81700279);the National Science Fund for Distinguished Young Scholars(No.81725002).
Metrics To the editor:The diabetes epidemic has increasingly become a major public health concern worldwide.In 2014,there were 102.9 million diabetic adults in China,representing 24.4%of the world's diabetic populatio...
关键词：DIABETES PREVALENCE eliminate 
MicroRNA Dysregulation and Steroid Hormone Receptor Expression in Uterine Tissues of Rats with Endometriosis during the Implantation Window被引量：8
《Chinese Medical Journal》2018年第18期2193-2204,共12页Han Cai Xin-Xin Zhu Zhan-Fei Li Ya-Pei Zhu Jing-He Lang 
Background： Estrogen receptor （ER） and progesterone receptor （PR） are involved in endometriosis, but the involvement of microRNAs （miRNAs） is unknown. The aim of the study was to explore the correlation between...
关键词：ENDOMETRIOSIS Estrogen Receptor IMPLANTATION MICRORNA Progesterone Receptor 
Distinct Rab7-related Endosomal-Autophagic-Lysosomal Dysregulation Observed in Cortex and Hippocampus in APPswe/PSEN1dE9 Mouse Model of Alzheimer＇s Disease被引量：6
《Chinese Medical Journal》2017年第24期2941-2950,共10页Li Ba Xiao-Hua Chen Yan-Lin Chen Qing Nie Zhi-Jun Li Feng-Fei Ding Min Zhang 
This work was supported by a grant of National Natural Science Foundation of China （No. 81271406）.
Background：Amyloid-β deposition and accumulation of autophagic vacuoles are pathologic features of Alzheimer＇s disease （AD）.Dysregulation of the endosomal-autophagic-lysosomal （EAL） pathway,which impairs amyloi...
关键词：Autophagy Class III Phosphatidylinositol 3-Kinase Complex ENDOCYTOSIS NEURODEGENERATION Rab7 
Psychiatric Symptoms in Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Syndrome and its Treatment： A Case Report被引量：1
《Chinese Medical Journal》2016年第2期242-243,共2页Habib Erensoy Mehmet Emin Ceylan Alper Evrensel 
To the Editor： Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation （ROHHAD） syndrome is a rare disease. It is diagnosed in childhood （usually at 3-4 years of age）. It a...
Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines被引量：5
《Chinese Medical Journal》2007年第24期2185-2190,共6页CHEN Ya-xi RUAN Xiong-zhong HUANG Ai-long LI Qiu John F. Moorhead Zac Varghese 
This study was supported by grants from the National Natural Science Foundation of China(Key Program,No.30530360);the National Basic Research Program of China(No.2006CB503907);Royal Free Hospital Special Trustees grant
Background Low-density lipoprotein （LDL） receptor is normally regulated via a feedback system that is dependent on intracellular cholesterol levels. We have demonstrated that cytokines disrupt cholesterol-mediated L...
关键词：low-density lipoprotein receptor CYTOKINES sterol regulatory element binding protein-2 SREBP cleavage-activating protein CHOLESTEROL 
Dysregulation of apoptosis: a possible mechanism leading to chronic progressive renal histological changes in lupus nephritis被引量：3
《Chinese Medical Journal》2000年第12期26-30,共5页陆福明 沈雯 张秀荣 郭慕依 林善锬 
This work was supported by a grant from Shanghai Scientific Technologi cal Committee(No 954119005).
To evaluate apoptosis in lupus nephritis and the relationship between the existence of apoptotic cells in renal tissue and histopathological or clinical changes Methods Apoptosis was detected by in situ nick end l...
关键词：lupus nephritis APOPTOSIS proliferating cell nuclear antigen 
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