Telomerase is a unique ribonucleoprotein complex that protects chromosomes from degradation and recombination. The defects in telomerase activity eansed by the mutations in telomerase RNA (hTER) is associated with s...
Telomere maintenance genes play an important role in maintaining the integrity of the telomere structure that protects chromosome ends,and telomere dysfunction may lead to tumorigenesis.Genetic variation in telomere m...
Budding yeast Cdc13-Stnl-Tenl (CST) complex plays an essential role in telomere protection and maintenance, and has been proposed to be a telomere-specific replication protein A (RPA)-like complex. Previous geneti...
Financial supports from the National Natural Science Foundation of China(No.20602015)are gratefully acknowledged.
p-tert-Butylcalix[4]diazacrown-4 telomer, which contains hard and soft ion binding sites, was synthesized. It exhibited high selectivity toward cesium ions. The binding sites may complex alkali metal ions selectively.