the Projects of International Cooperation National Key R&D Program of China(Grant No.2022YFE0108300);the National Key Research and Development Program of China(Grant No.2022YFF1003000);the National Natural Science Foundation of China(Grant Nos.32372682,32272747,32072585,32072568).
Selenocysteine methyltransferase(SMT)is a key enzyme involved in the Se metabolism pathway,and it is responsible for the catalysis of Se-methylselenocysteine(SeMSC)compound formation.Previous studies showed that selen...
Supported by National Innovation and Entrepreneurship Training Program for College Students(202210580007).
The global understanding of selenium(Se)in plant biology mainly comes from the fields of medicine and animal science,while the research on Se in plant biology in the field of plant science lags behind.This paper summa...
supported by the National Natural Science Foundation of China(21775091,91753111,21927811);the Key Research and Development Program of Shandong Province(2018YFJH0502)。
Developing accurate methods for visualizing the expressions of proteins during the life process is a hotspot in the biochemical research field.Glutathione peroxidase 4(GPX4),one type of selenoproteins,was previously i...
supported by the Sci-Tech Development Project of Taian in Shandong,No.2016NS1058&2015NS2081;the Sci-Tech Development Project of Linyi in Shandong,No.201515006
Designing and/or searching for novel antioxidants against oxygen glucose effective strategy for the treatment of human isdlemic stroke. Selenium is deprivation (OGD)-induced oxidative damage represents an an essenti...
Selenium (Se) is a trace element required for normal body function. Its supplementation of human diet at standard optimum amount prevents oxidative damages in cells and could be a viable method in the prevention of di...
Supported by the National Nature Science Foundation of China(Nos.31070772, 31270907, 21002040, 30970608) and the Doctoral Program of Higher Education of China(No.200901011110136).
In Escherichia coil four gene products(selA, selB, selC and selD) and a selenocysteine(Sec) insertion sequence(SECIS) are required for the correct translation of UGA codons encoding Sec. Previous studies have sh...
Tea plant (Camellia sinensis) has unique biological features for the study of cellular and molecular mechanisms, an evergreen broad-leaved woody plant which can accumulate selenium in soil abundant of Selenium. Expres...
Incorporation of Selenocysteine into protein requires an RNA structural motif, SECIS (Selenocysteine insertion sequence) element that, along with other factors, demarcates UGA-Sec from the UGA termination codon, for e...
supported by the National Natu-ral Science Foundation of China under Grant No.30525037;the National 863 Program under Grant No. 2004AA231060
The genetic codon UGA has a dual function: serving as a terminator and encoding selenocysteine. However, most popular gene annotation programs only take it as a stop signal, resulting in misannotation or completely m...
the National Natural Science Foundation of China (Grant Nos. 30370352 and 30570420)
Selenoprotein is biosynthesized by the incorporation of selenocysteine into proteins,where the TGA codon in the open reading frame does not act as a stop signal but is translated into selenocysteine.The dual functions...